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Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

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About the Cancer Immunoprevention Network

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Alexandrov, Ludmil B

University Of California, San Diego
United States

Mapping immuno-genomic drivers of the head and neck precancer invasive-disease transition 5U01CA290479-03 Wendy Wang, Ph.D., M.Sc.
Allen, Peter J

Duke University
United States

Biomarker validation for intraductal papillary mucinous neoplasms of the pancreas 5R01CA182076-08 Matthew Young, Ph.D.
Amuta, Ann Oyare

University Of Texas Arlington
United States

Development of Tailored, Multilevel Cervical Cancer Interventions for Ethnically Diverse Black Women 1R15CA294297-01 Goli Samimi, Ph.D., M.P.H.
Anderson, Karen Sue

Arizona State University-Tempe Campus
United States

Southwest EDRN Clinical Validation Center for Head and Neck Cancer 5U01CA281660-03 Wendy Wang, Ph.D., M.Sc.
Anderson, Karen Sue

Arizona State University-Tempe Campus
United States

Southwest EDRN Clinical Validation Center for Head and Neck Cancer 5U01CA281660-03 Wendy Wang, Ph.D., M.Sc.
Anderson, Garnet L.

Fred Hutchinson Cancer Center
United States

NCI Cancer Screening Research Network: Coordinating and Communication Center 3UG1CA286954-02S1 Elyse LeeVan, M.D., M.P.H.
Anderson, Daniel M

Healthpartners Institute
United States

Metro-Minnesota Community Oncology Research Consortium (MMCORC) 3UG1CA189863-12S1 Vanessa A. White, M.P.H.
Anderson, Daniel M

Healthpartners Institute
United States

Metro-Minnesota Community Oncology Research Consortium (MMCORC) 3UG1CA189863-12S1 Vanessa A. White, M.P.H.
Arnold, Corey Wells

University Of California Los Angeles
United States

Computational Feature Profiling and Modeling for Prostate Cancer Detection and Risk Stratification 5R01CA279666-02 Indu Kohaar, Ph.D., M.Phil., M.Sc.
Atigadda, Venkatram Reddy

University Of Alabama At Birmingham
United States

Development of Potent and non-toxic rexinoids to prevent non-melanoma skin cancer 5R01CA276683-03
Backman, Vadim

Northwestern University At Chicago
United States

Optical hyperspectral nanoscale chromatin analysis for colon cancer risk-stratification 1R01CA289294-01A1 Claire Zhu, Ph.D.
Badu-Tawiah, Abraham

Ohio State University
United States

Multiplexed Paper-Based Blood Test for Early-Stage Colorectal Cancer Screening 5R21CA270727-02 Claire Zhu, Ph.D.
Badve, Sunil S.

Emory University
United States

Early prediction of lethal phenotypes in triple negative breast cancer using multiscale, multi-modality platforms 5R01CA281932-02 Wendy Wang, Ph.D., M.Sc.
Bae-Jump, Victoria Lin

Univ Of North Carolina Chapel Hill
United States

Obesity-driven Metabolic and Molecular Biomarkers of Metformin Response in Endometrial Cancer 5R37CA226969-07 Goli Samimi, Ph.D., M.P.H.
Baghdadi, Tareq Al

Saint Joseph Mercy Health System
United States

Michigan Cancer Research Consortium NCORP 3UG1CA189971-11S1 Vanessa A. White, M.P.H.

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554