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Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

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About the Cancer Immunoprevention Network

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Chirenje, Zvavahera Mike

University Of California, San Francisco
United States

Implementing HIV/Cervical Cancer Prevention CASCADE Clinical Trials in Zimbabwe (ZIM-CASCADE) 3UG1CA284918-03S1 Maria Silvina Frech, Ph.D., M.S.
Chong, Catherine Daniela

Mayo Clinic Arizona
United States

Biomarker Signature to Predict the Persistence of Post-Traumatic Headache 5R33NS113315-03 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Chong, Catherine Daniela

Mayo Clinic Arizona
United States

Biomarker Signature to Predict the Persistence of Post-Traumatic Headache 5R33NS113315-03 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Chung, Ki Young

Prisma Health - Upstate
United States

NCORP of the Carolinas (Greenville Health System NCORP) 3UG1CA189972-11S1 Vanessa A. White, M.P.H.
Chung, Ki Young

Prisma Health - Upstate
United States

NCORP of the Carolinas (Greenville Health System NCORP) 3UG1CA189972-11S1 Vanessa A. White, M.P.H.
Chung, Raymond T

Massachusetts General Hospital
United States

Trial of Statins for Chemoprevention in Hepatocellular Carcinoma 4R01CA255621-05 Asad Umar, D.V.M., Ph.D.
Chung, Michael Hoonbae

Emory University
United States

HIV/cervical cancer cOntrol and Prevention clinical sitE in Kenya (HOPE-Kenya) 3UG1CA275400-04S1 Maria Silvina Frech, Ph.D., M.S.
Clapper, Margie L.

Research Inst Of Fox Chase Can Ctr
United States

Folic Acid Supplementation and Colitis-associated Colon Carcinogenesis 5R01CA262551-04 Nancy J. Emenaker, Ph.D., RDN, LD, FAND
Clapper, Margie L.

Research Inst Of Fox Chase Can Ctr
United States

Cancer Prevention-Interception Targeted Agent Discovery Program at Fox Chase Cancer Center 5U54CA272686-04
Clare, Susan E.

Northwestern University At Chicago
United States

Lipid-initiated epigenetic reprogramming of the breast to a neural phenotype 1R21CA288676-01A1
Cocucci, Emanuele

Ohio State University
United States

A SYNTHETIC BIOMARKER TO UNIVERSALLY ASSESS THE RELATIVE CONTRIBUTION OF HEATHY AND CANCEROUS TISSUE TO CIRCULATING EV POOL 5R01CA270251-03 Matthew Young, Ph.D.
Cohen, Lorenzo

University Of Tx Md Anderson Can Ctr
United States

Opioid-Sparing Effects of Nurse-Delivered Hypnosis During Breast Cancer Surgery 5R01CA272565-03 Brennan Streck, Ph.D., RN, M.P.H.
Cohen, Lorenzo

University Of Tx Md Anderson Can Ctr
United States

Opioid-Sparing Effects of Nurse-Delivered Hypnosis During Breast Cancer Surgery 5R01CA272565-03 Brennan Streck, Ph.D., RN, M.P.H.
Cohn, Barbara A

Public Health Institute
United States

Discriminatory Mechanisms in Early-Onset and Lethal Prostate Cancer 5R01CA264519-05 Howard L. Parnes, M.D.
Cook, Linda S

University Of Colorado Denver
United States

NOT-CA-24-111 Improving Strategies for Cancer Reduction through Early-detection and ENgagement (I-SCREEN) 3UG1CA286941-02S1 Elyse LeeVan, M.D., M.P.H.

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554