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Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

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About the Cancer Immunoprevention Network

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name PI Organization Title Grant Number Program Official
Zarrinpar, Amir

University Of California, San Diego
United States

 Engineering Native E. coli to Detect, Report, and Treat Colorectal Cancer 5U01CA265719-05 Guillermo Marquez, Ph.D.
Zeng, Melody Yue

Weill Medical Coll Of Cornell Univ
United States

 Dissecting the interplay between immunoglobulin G and the gut microbiome in cancer progression and metastasis 5R21CA270998-02 Young Kim, Ph.D.
Zhang, Zhen

Johns Hopkins University
United States

 A multidisciplinary BCC for ovarian cancer early detection: translating discoveries to clinical use with a by-design approach 5U2CCA271891-04 Christos Patriotis, Ph.D., M.Sc.
Zhao, Hua

University Of Virginia
United States

 Homologous recombination repair capacity in peripheral blood lymphocytes as a breast cancer risk factor 4U01CA260731-04 Claire Zhu, Ph.D.
Zhao, Yingqi

Fred Hutchinson Cancer Center
United States

 Developing methods for advancing the early detection of pancreatic ductal adenocarcinoma leveraging electronic medical records data 1R01CA289668-01A1 Matthew Young, Ph.D.
Zheng, Qin

Johns Hopkins University
United States

 Determining the function of medium to large diameter sensory neurons in paclitaxel-induced pain via large-scale in vivo DRG imaging 1R01CA291906-01A1 Rachel Altshuler, Ph.D.
Zheng, Yingye

Fred Hutchinson Cancer Center
United States

 The Early Detection Research Network: Data Management and Coordinating Center 5U24CA086368-25 Guillermo Marquez, Ph.D.
Zheng, Yingye

Fred Hutchinson Cancer Center
United States

 The Early Detection Research Network: Data Management and Coordinating Center 5U24CA086368-25 Guillermo Marquez, Ph.D.
Zheng, Qin

Johns Hopkins University
United States

 Determining the function of medium to large diameter sensory neurons in paclitaxel-induced pain via large-scale in vivo DRG imaging 1R01CA291906-01A1 Rachel Altshuler, Ph.D.
Zheng, Qin

Johns Hopkins University
United States

 Determining the function of medium to large diameter sensory neurons in paclitaxel-induced pain via large-scale in vivo DRG imaging 1R01CA291906-01A1 Rachel Altshuler, Ph.D.
Zheng, Yingye

Fred Hutchinson Cancer Center
United States

 Precompetitive Collaboration on Liquid Biopsy for Early Cancer Assessment: Data Management and Coordinating Unit 5U24CA288185-03 Guillermo Marquez, Ph.D.
Zhou, Xianghong Jasmine

University Of California Los Angeles
United States

 Multi-cancer early detection using cell-free DNA methylome analysis 5U01CA285010-03 Nicholas Hodges, Ph.D.
Zhou, Xianghong Jasmine

University Of California Los Angeles
United States

 Detecting and locating cancer for patients with CT-detected lung nodules 4R01CA264864-04 Guillermo Marquez, Ph.D.
Zhou, Xianghong Jasmine

University Of California Los Angeles
United States

 The UCLA Center in Early Detection of Liver Cancer 5U01CA230705-08 Sidney Fu, M.D.
Zhu, Yong

Univ Of Arkansas For Med Scis
United States

 Explore piRNAs as a novel group of biomarkers for ovarian cancer early detection 1R21CA277412-01A1 Christos Patriotis, Ph.D., M.Sc.

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554