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Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

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About the Cancer Immunoprevention Network

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Yaddanapudi, Kavitha

University Of Louisville
United States

A Stem Cell Based Exosomal Vaccine for the Prevention of Cancer 5R21CA277314-02
Yaghjyan, Lusine

University Of Florida
United States

Stromal contributions to breast carcinogenesis 5R01CA277817-03 Christos Patriotis, Ph.D., M.Sc.
Yang, Qing

University Of Texas Med Br Galveston
United States

The role of acute excitation of sensory neurons in the development of paclitaxel-induced peripheral neuropathy 5R01CA273001-02 Rachel Altshuler, Ph.D.
Yang, Qing

University Of Texas Med Br Galveston
United States

The role of acute excitation of sensory neurons in the development of paclitaxel-induced peripheral neuropathy 5R01CA273001-02 Rachel Altshuler, Ph.D.
Yang, Wan

Columbia University Health Sciences
United States

UNCOVER: underlying novel causes of onset of very early cancer research 5R01CA257971-05 Nicholas Hodges, Ph.D.
Yeh, Jennifer M.

Boston Children'S Hospital
United States

Can risk-reducing medications improve breast cancer prevention in childhood and adolescent cancer survivors? Comparative modeling to inform care 5R01CA261874-04 Eileen Dimond, R.N., M.S.
Yendamuri, Saikrishna

Roswell Park Cancer Institute Corp
United States

Metformin for chemoprevention of lung cancer in obese subjects at high risk 5R01CA255515-05 Malgorzata Wojtowicz, M.D.
Yilmaz, Omer

Massachusetts Institute Of Technology
United States

PROSPECT - Stem cell models 3OT2CA297570-01S1 Asad Umar, D.V.M., Ph.D.
You, Ming

Methodist Hospital Research Institute
United States

Targeting phenethyl isothiocyanate to mitochondria in lung carcinogenesis 5R01CA280746-02 John Clifford, Ph.D.
Young, Steven L

Duke University
United States

Collaborative Center to Develop Improved Diagnostic and Therapeutic Approaches to Endometriosis 5P01HD106485-05 Goli Samimi, Ph.D., M.P.H.
Yu, Anthony Francis

Sloan-Kettering Inst Can Research
United States

Intensive Blood Pressure Control During Cardiotoxic Breast Cancer Treatment (PROTECT) Trial 5R37CA273923-03 Eileen Dimond, R.N., M.S.
Yu, Anthony Francis

Sloan-Kettering Inst Can Research
United States

Intensive Blood Pressure Control During Cardiotoxic Breast Cancer Treatment (PROTECT) Trial 5R37CA273923-03 Eileen Dimond, R.N., M.S.
Yu, Dihua

University Of Tx Md Anderson Can Ctr
United States

Exploring novel strategies for immunoprevention of estrogen receptor negative breast cancer 5R01CA270010-03 Marjorie Perloff, M.D.
Yu, Danxia

Vanderbilt University Medical Center
United States

Gut microbiota-related mechanisms that impact colorectal cancer risk after bariatric surgery 5R01CA275864-03 Edward Sauter, M.D., Ph.D.
Yuan, Ying

University Of Tx Md Anderson Can Ctr
United States

Coordinating and Data Management Center for Translational and Basic Science Research in Early Lesions 5U24CA274212-04 Christos Patriotis, Ph.D., M.Sc.

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554