Skip to main content
An official website of the United States government

Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

On This Page

  • All Heading 2s will automatically be pulled in to this list.
  • Do not edit the content on this template.

About the Cancer Immunoprevention Network

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Sieren, Jessica C

University Of Iowa
United States

Lung cancer screening efficacy enhanced through radiomic and epigenetic biomarkers 5R01CA267820-03 Nicholas Hodges, Ph.D.
Sigel, Keith Magnus

Icahn School Of Medicine At Mount Sinai
United States

The effectiveness of screening women with lower genital tract neoplasia or cancers for anal cancer precursors 4R01CA256660-05 Vikrant Sahasrabuddhe, M.B.B.S., M.P.H., Dr.P.H.
Simeone, Diane M

University Of California, San Diego
United States

Biomarker Validation in Pancreatic Cystic Neoplasms 5U01CA282272-03 Matthew Young, Ph.D.
Siminski, Suzanne M.

Frontier Sci & Technology Rsch Fdn, Inc
United States

CASCADE Coordinating Center 5U24CA275417-04 Maria Silvina Frech, Ph.D., M.S.
Singal, Amit

Ut Southwestern Medical Center
United States

Clinical Validation Center for Hepatocellular Carcinoma 5U01CA271887-04 Indu Kohaar, Ph.D., M.Phil., M.Sc.
Singal, Amit

Ut Southwestern Medical Center
United States

Precision Risk Stratification and Screening for HCC among Patients with Indeterminate Liver Nodules 4U01CA283935-03 Sidney Fu, M.D.
Singal, Amit

Ut Southwestern Medical Center
United States

Clinical Validation Center for Hepatocellular Carcinoma 5U01CA271887-04 Indu Kohaar, Ph.D., M.Phil., M.Sc.
Singal, Amit

Ut Southwestern Medical Center
United States

Precision Screening for Hepatocellular Carcinoma in Patients with Cirrhosis 5R01CA222900-06
Singal, Amit

Ut Southwestern Medical Center
United States

Precision Risk Stratification and Screening for HCC among Patients with Cirrhosis in the United States 5U01CA230694-05
Siskind, Leah J

University Of Louisville
United States

Protecting the kidney from cisplatin induced injury and progression to chronic kidney disease 1R01CA305985-01 Marjorie Perloff, M.D.
Siskind, Leah J

University Of Louisville
United States

Protecting the kidney from cisplatin induced injury and progression to chronic kidney disease 1R01CA305985-01 Marjorie Perloff, M.D.
Skates, Steven J

Massachusetts General Hospital
United States

Proteomic Analyses of Serial Prediagnostic PLCO Serum in Cases and Controls to Identify Early Detection Ovarian Cancer Biomarkers Rising in a Substantial Fraction of Cases and Stable in Most Controls 5U01CA260758-05 Claire Zhu, Ph.D.
Skates, Steven J

Massachusetts General Hospital
United States

Genome-wide methylation and proteomic analysis of uterine lavage and cervical swab for early detection of ovarian cancer 5U2CCA271871-03 Christos Patriotis, Ph.D., M.Sc.
Skubitz, Amy Patrice

University Of Minnesota
United States

A paradigm shift for ovarian cancer biomarkers: Utilizing routine Pap tests as liquid biopsies for the development of targeted mass spectrometry-based proteomic assays for early detection 5R01CA262153-05 Christos Patriotis, Ph.D., M.Sc.
Slager, Susan L

Mayo Clinic Rochester
United States

The genetic and epigenetic etiology of progression from the precursor state to chronic lymphocytic leukemia (CLL) 4R01CA258465-04 Nicholas Hodges, Ph.D.

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554