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Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

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About the Cancer Immunoprevention Network

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Shah, Sohrab P

Sloan-Kettering Inst Can Research
United States

Exploiting markers of genomic instability in high-risk pre-invasive ovarian cancer 5R01CA281928-03 Christos Patriotis, Ph.D., M.Sc.
Shain, Alan Hunter

University Of California, San Francisco
United States

Pre-cancer atlas of skin cancer 4U01CA294536-02 Nicholas Hodges, Ph.D.
Shalon, Tidhar Dari

Envivo Bio Inc
United States

Development and clinical evaluation of the CapScan gastrointestinal sampling device for metabolomics monitoring 5R33CA260665-04 Amit Kumar, Ph.D.
Shelby, Rebecca A

Duke University
United States

Improving outcomes for women experiencing premature or early menopause after cancer: development and pilot testing of a novel intervention 1R21CA301298-01 Goli Samimi, Ph.D., M.P.H.
Shelby, Rebecca A

Duke University
United States

Persistent Post-Mastectomy Pain: Randomized Clinical Trial of Targeted Pain Coping Skills Training (Targeted-PCST) with Mediational Analysis 5R01CA249959-05 Brennan Streck, Ph.D., RN, M.P.H.
Shelby, Rebecca A

Duke University
United States

Persistent Post-Mastectomy Pain: Randomized Clinical Trial of Targeted Pain Coping Skills Training (Targeted-PCST) with Mediational Analysis 5R01CA249959-05 Brennan Streck, Ph.D., RN, M.P.H.
Shelby, Rebecca A

Duke University
United States

Improving outcomes for women experiencing premature or early menopause after cancer: development and pilot testing of a novel intervention 1R21CA301298-01 Goli Samimi, Ph.D., M.P.H.
Shiozawa, Yusuke

Wake Forest University Health Sciences
United States

Contribution of cutaneous neuro-immune interactions to chemotherapy-induced peripheral neuropathy 1R21CA297068-01 Rachel Altshuler, Ph.D.
Shiozawa, Yusuke

Wake Forest University Health Sciences
United States

Contribution of cutaneous neuro-immune interactions to chemotherapy-induced peripheral neuropathy 1R21CA297068-01 Rachel Altshuler, Ph.D.
Shirwan, Haval

University Of Missouri-Columbia
United States

Developing a novel agonist of CD137 for cancer immunoprevention 5UG3CA290305-02 Altaf Mohammed, Ph.D.
Shu, Xiao-Ou

Vanderbilt University Medical Center
United States

Use of Circulating MicroRNAs for Early Detection and Risk Assessment for Pancreatic Cancer 5R01CA227133-05 Matthew Young, Ph.D.
Shureiqi, Imad

University Of Michigan At Ann Arbor
United States

ALOX15 regulation of colon cancer invasiveness via PI3P-linoleic acid metabolism 5R01CA266223-04 Nancy J. Emenaker, Ph.D., RDN, LD, FAND
Siddique, Shahzad

Commonspirit Health Research Institute
United States

CIRI Oncology Research Alliance 3UG1CA189809-11S1 Vanessa A. White, M.P.H.
Siddique, Shahzad

Commonspirit Health Research Institute
United States

CIRI Oncology Research Alliance 3UG1CA189809-11S1 Vanessa A. White, M.P.H.
Sidransky, David

Johns Hopkins University
United States

Racial differences in Immunogenetic Tumorigenesis of Head and Neck Squamous Cell Carcinoma 5R01CA265975-04 Wendy Wang, Ph.D., M.Sc.

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554