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Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

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About the Cancer Immunoprevention Network

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Blanke, Charles D.

Oregon Health & Science University
United States

SWOG NCORP Research Base 3UG1CA189974-11S1 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Boone, Anna

University Of Missouri-Columbia
United States

Pilot testing of metacognitive strategy training to address cancer-related cognitive impairment in breast cancer 1R21CA286404-01A1 Marjorie Perloff, M.D.
Boone, Anna

University Of Missouri-Columbia
United States

Pilot testing of metacognitive strategy training to address cancer-related cognitive impairment in breast cancer 1R21CA286404-01A1 Marjorie Perloff, M.D.
Borges, Chad R

Arizona State University-Tempe Campus
United States

Plate reader assays to forensically assess exposure of plasma and serum to thawed conditions 5R21CA269091-03 Indu Kohaar, Ph.D., M.Phil., M.Sc.
Boutros, Paul Christopher

University Of California Los Angeles
United States

Germline Determinants of Prostate Cancer Evolution 5R01CA270108-03 Guillermo Marquez, Ph.D.
Bower, Julienne E

University Of California Los Angeles
United States

Mindfulness Meditation for Younger Breast Cancer Survivors: Testing Digital Interventions in Clinical and Community Settings 5R01CA282416-02 Brennan Streck, Ph.D., RN, M.P.H.
Bower, Julienne E

University Of California Los Angeles
United States

Mindfulness Meditation for Younger Breast Cancer Survivors: Testing Digital Interventions in Clinical and Community Settings 5R01CA282416-02 Brennan Streck, Ph.D., RN, M.P.H.
Boyer, Thomas G

University Of Texas Hlth Science Center
United States

Pathological reprogramming of the m6A epitranscriptome in uterine fibroids 5R01HD106285-05 Goli Samimi, Ph.D., M.P.H.
Brand, Randall

University Of Pittsburgh At Pittsburgh
United States

Validation of biomarkers for risk prediction and early diagnosis of Pancreatic Adenocarcinoma 5U01CA200466-08 Matthew Young, Ph.D.
Brand, Randall

University Of Pittsburgh At Pittsburgh
United States

Validation of biomarkers for risk prediction and early diagnosis of Pancreatic Adenocarcinoma 5U01CA200466-08 Matthew Young, Ph.D.
Brinkman, Tara M

St. Jude Children'S Research Hospital
United States

Culturally adapted mobile treatment of chronic pain in adolescent survivors of pediatric bone sarcoma 4R33CA280978-02 Rachel Altshuler, Ph.D.
Brinkman, Tara M

St. Jude Children'S Research Hospital
United States

Culturally adapted mobile treatment of chronic pain in adolescent survivors of pediatric bone sarcoma 4R33CA280978-02 Rachel Altshuler, Ph.D.
Brown, Austin L

Baylor College Of Medicine
United States

A Systems Epidemiology Approach for Predicting Methotrexate Neurotoxicity in Pediatric Acute Leukemia 5R01CA272981-03 Rachel Altshuler, Ph.D.
Brown, Austin L

Baylor College Of Medicine
United States

A Systems Epidemiology Approach for Predicting Methotrexate Neurotoxicity in Pediatric Acute Leukemia 5R01CA272981-03 Rachel Altshuler, Ph.D.
Brown, Austin L

Baylor College Of Medicine
United States

A Systems Epidemiology Approach for Predicting Methotrexate Neurotoxicity in Pediatric Acute Leukemia 5R01CA272981-03 Rachel Altshuler, Ph.D.

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554