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Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

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About the Cancer Immunoprevention Network

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Plas, Ellen Van Der

Arkansas Children'S Hospital Res Inst
United States

Identifying markers of abnormal neurocognitive trajectories during chemotherapy treatment of childhood acute lymphoblastic leukemia 5R37CA266135-04 Asad Umar, D.V.M., Ph.D.
Plas, Ellen Van Der

Arkansas Children'S Hospital Res Inst
United States

Identifying markers of abnormal neurocognitive trajectories during chemotherapy treatment of childhood acute lymphoblastic leukemia 5R37CA266135-04 Asad Umar, D.V.M., Ph.D.
Porter, Laura S

Duke University
United States

Couple Communication Skills Training for Advanced Cancer 5R01CA229425-05 Brennan Streck, Ph.D., RN, M.P.H.
Porter, Laura S

Duke University
United States

Couple Communication Skills Training for Advanced Cancer 5R01CA229425-05 Brennan Streck, Ph.D., RN, M.P.H.
Pozdeyev, Nikita

University Of Colorado Denver
United States

Genetic architecture of thyroid cancer and its clinical utility 5R21CA282380-02 Wendy Wang, Ph.D., M.Sc.
Prigerson, Holly Gwen

Weill Medical Coll Of Cornell Univ
United States

Behavioral and Psychosocial Effects on Study Outcomes in End-Stage Cancer Treatment (BEST End-Stage Cancer Study) 5R35CA197730-11 Brennan Streck, Ph.D., RN, M.P.H.
Prigerson, Holly Gwen

Weill Medical Coll Of Cornell Univ
United States

Behavioral and Psychosocial Effects on Study Outcomes in End-Stage Cancer Treatment (BEST End-Stage Cancer Study) 5R35CA197730-11 Brennan Streck, Ph.D., RN, M.P.H.
Punnen, Sanoj

University Of Miami School Of Medicine
United States

The Rigor and Clinical Utility of PSMA Enriched Extracellular Vesicles for Prostate Cancer Detection 5R01CA272766-03 Matthew Young, Ph.D.
Pyter, Leah M

Ohio State University
United States

Chemotherapy-induced circadian master clock disruptions and fatigue 3R01CA270372-03S1 Marjorie Perloff, M.D.
Pyter, Leah M

Ohio State University
United States

Chemotherapy-induced circadian master clock disruptions and fatigue 3R01CA270372-03S1 Marjorie Perloff, M.D.
Rajagopalan, Malolan S

Columbus Community Clinical Oncology Prg
United States

Columbus NCORP RFA-CA-18-016 3UG1CA189954-11S1 Vanessa A. White, M.P.H.
Rajagopalan, Malolan S

Columbus Community Clinical Oncology Prg
United States

Columbus NCORP RFA-CA-18-016 3UG1CA189954-11S1 Vanessa A. White, M.P.H.
Rajkumar, S Vincent

Mayo Clinic Rochester
United States

Onset and biomarkers for progression of monoclonal gammopathies 5R01CA168762-11 Nicholas Hodges, Ph.D.
Ramanujam, Nirmala

Duke University
United States

Development and Validation of an Artificial-Intelligence-enabled Portable Colposcopy Device for Optimizing Triage Alternatives for HPV-based Cervical Cancer Screening 3U01CA269192-04S1 Vikrant Sahasrabuddhe, M.B.B.S., M.P.H., Dr.P.H.
Rao, Chinthalapally V.

University Of Oklahoma Hlth Sciences Ctr
United States

Discovery and Development of Natural Products for Interception of CRC 5UG3CA290310-02 Kajal Biswas, Ph.D.

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554