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Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

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About the Cancer Immunoprevention Network

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Onitilo, Adedayo A

Marshfield Clinic Research Foundation
United States

Wisconsin NCI Community Oncology Research Program (WiNCORP) 3UG1CA189956-11S1 Vanessa A. White, M.P.H.
Onitilo, Adedayo A

Marshfield Clinic Research Foundation
United States

Wisconsin NCI Community Oncology Research Program (WiNCORP) 3UG1CA189956-11S1 Vanessa A. White, M.P.H.
Osarogiagbon, Raymond U

Baptist Memorial Hospital - Tipton
United States

Baptist Memorial Health Care/Mid South NCORP Consortium 3UG1CA189873-11S1 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Osarogiagbon, Raymond U

Baptist Memorial Hospital - Tipton
United States

Baptist Memorial Health Care/Mid South NCORP Consortium 3UG1CA189873-11S1 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Oskeritzian, Carole A

University Of South Carolina At Columbia
United States

Novel modalities for prostate cancer screening: mast cells as predictors of disease, disease aggressiveness and marks of disease disparity 5R21CA274021-02 Guillermo Marquez, Ph.D.
Ostrin, Edwin Justin

University Of Tx Md Anderson Can Ctr
United States

Validation of blood-based biomarkers for risk assessment of lung cancer among individuals with no smoking history in the PLCO Cohort 1U01CA295902-01A1 Claire Zhu, Ph.D.
Palefsky, Joel Michael

University Of California, San Francisco
United States

California-Mexico-Puerto Rico Partnership (CAMPO) Center for Prevention of HPV-related Cancer in HIV+ Populations 3U54CA242646-06S3 Maria Silvina Frech, Ph.D., M.S.
Palesh, Oxana G

Virginia Commonwealth University
United States

Multicenter Randomized Controlled Trial of Brief Behavioral Therapy for Cancer Related Insomnia 5R01CA239714-07 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Palesh, Oxana G

Virginia Commonwealth University
United States

Multicenter Randomized Controlled Trial of Brief Behavioral Therapy for Cancer Related Insomnia 5R01CA239714-07 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Panda, Satchidananda

Salk Institute For Biological Studies
United States

Impact of Time-Restricted Feeding in Reducing Cancer Risk Through Optimizing Mitochondria Function 5R01CA258221-05 Nancy J. Emenaker, Ph.D., RDN, LD, FAND
Pandharipande, Pari Vijay

Ohio State University
United States

Precision Management of Cystic Precursors to Pancreatic Cancer 5R01CA237133-06 Matthew Young, Ph.D.
Panigrahy, Dipak

Beth Israel Deaconess Medical Center
United States

Control of cancer cachexia via stimulation of resolution of inflammation 5R01CA276107-02 Marjorie Perloff, M.D.
Panigrahy, Dipak

Beth Israel Deaconess Medical Center
United States

Control of cancer cachexia via stimulation of resolution of inflammation 5R01CA276107-02 Marjorie Perloff, M.D.
Panikkar, Rajiv

Geisinger Clinic
United States

Geisinger Cancer Institute - NCI Community Oncology Research Program (NCORP) 3UG1CA189847-11S1 Vanessa A. White, M.P.H.
Panikkar, Rajiv

Geisinger Clinic
United States

Geisinger Cancer Institute - NCI Community Oncology Research Program (NCORP) 3UG1CA189847-11S1 Vanessa A. White, M.P.H.

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554