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Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

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About the Cancer Immunoprevention Network

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Hanash, Samir M

University Of Tx Md Anderson Can Ctr
United States

Clinical Validation Center for Lung Cancer Early Detection 4U01CA271888-04 Guillermo Marquez, Ph.D.
Hanash, Samir M

University Of Tx Md Anderson Can Ctr
United States

Clinical Validation Center for Lung Cancer Early Detection 4U01CA271888-04 Guillermo Marquez, Ph.D.
Hanks, Brent Allen

Univ Of North Carolina Chapel Hill
United States

Role of the tumor NLRP3 inflammasome in the generation of anti-PD-1 antibody immunotherapy-associated toxicities 7R01CA251136-05 Marjorie Perloff, M.D.
Hanks, Brent Allen

Univ Of North Carolina Chapel Hill
United States

Role of the tumor NLRP3 inflammasome in the generation of anti-PD-1 antibody immunotherapy-associated toxicities 7R01CA251136-05 Marjorie Perloff, M.D.
Hansen, Laura A

Creighton University
United States

Targeting aberrant anti-apoptotic signaling for prevention of skin cancer 5R01CA253573-05 Howard L. Parnes, M.D.
Harichand, Seema

Iowa Oncology Research Association
United States

Iowa-Wide Oncology Research Coalition (I-WORC) 3UG1CA189816-11S1 Vanessa A. White, M.P.H.
Harichand, Seema

Iowa Oncology Research Association
United States

Iowa-Wide Oncology Research Coalition (I-WORC) 3UG1CA189816-11S1 Vanessa A. White, M.P.H.
Harris, Holly Ruth

Fred Hutchinson Cancer Center
United States

Risk factors for and consequences of endometriosis among Black women 5R21HD115018-02 Goli Samimi, Ph.D., M.P.H.
Hartman, Terryl J.

Emory University
United States

Fiber-rich Foods to Treat Obesity and Prevent Colon Cancer 5R01CA245063-05 Nancy J. Emenaker, Ph.D., RDN, LD, FAND
Hawkins, Shannon Michelle

Indiana University Indianapolis
United States

Targeting cellular senescence to inhibit the development and progression of ovarian endometriomas 5R01HD109707-04 Goli Samimi, Ph.D., M.P.H.
Hayes, Richard Bernard

New York University School Of Medicine
United States

The Oral Microbiome and Upper Aerodigestive Squamous Cell Cancer 5R01CA159036-09 Claire Zhu, Ph.D.
Hebert, James R

University Of South Carolina At Columbia
United States

A Transdisciplinary Approach to Investigating Metabolic Dysregulation in Obese Parent and Child Dyads and Risk of Colorectal Cancer 3U01CA272977-03S1 Gabriela Riscuta, M.D., CNS
Hecht, Stephen S

University Of Minnesota
United States

High resolution mass spectrometric profile analysis of carcinogen-DNA adducts in oral cells of cigarette smokers and squamous cell carcinoma of the head and neck 5R01CA263084-05 Wendy Wang, Ph.D., M.Sc.
Heine, John J

H. Lee Moffitt Cancer Ctr & Res Inst
United States

Quantitative Imaging Clinical Validation Center at Moffitt Cancer Center 5U01CA200464-08 Guillermo Marquez, Ph.D.
Heine, John J

H. Lee Moffitt Cancer Ctr & Res Inst
United States

Quantitative Imaging Clinical Validation Center at Moffitt Cancer Center 5U01CA200464-08 Guillermo Marquez, Ph.D.

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554