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Consortium for Imaging and Biomarkers (CIB)

The Consortium for Imaging and Biomarkers (CIB) seeks to improve cancer screening, early detection of aggressive cancer, assessment of cancer risk, and cancer diagnosis by integrating imaging strategies with biomarkers into complementary approaches.

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About the Consortium for Imaging and Biomarkers

The Consortium for Imaging and Biomarkers aims to integrate imaging strategies and biomarker methodologies into a singular complementary approach to cancer detection. Investigators Work in multi-disciplinary teams to perform collaborative studies, exchange information, share knowledge and leverage common resources.

Overdiagnosis (finding cancers that will never affect a person’s health) and false positives (test results that show cancer when none is there) present significant clinical problems in the prevention, detection and treatment of cancer. There is a need to more accurately identify early-stage aggressive cancers and distinguish lesions that are life threatening from those that are not.

The Consortium for imaging and Biomarkers Research Units develop, optimize, and clinically validate novel methods to:

  • Detect aggressive cancers at the earliest stages possible;
  • Reduce overdiagnosis;
  • Reduce false positive tests; and
  • Identify lethal cancers from non-lethal disease.

The goal of the Consortium for imaging and Biomarkers is to develop improved methods for the early detection of aggressive cancer by managing overdiagnosis, reducing false positives and identifying lethal cancers from non-lethal disease using strategies aimed at effective integration and validation of imaging and biomarkers.

Funding Opportunity

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Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Sieren, Jessica C

University Of Iowa
United States

Lung cancer screening efficacy enhanced through radiomic and epigenetic biomarkers 5R01CA267820-03 Nicholas Hodges, Ph.D.
Sigel, Keith Magnus

Icahn School Of Medicine At Mount Sinai
United States

The effectiveness of screening women with lower genital tract neoplasia or cancers for anal cancer precursors 4R01CA256660-05 Vikrant Sahasrabuddhe, M.B.B.S., M.P.H., Dr.P.H.
Simeone, Diane M

University Of California, San Diego
United States

Biomarker Validation in Pancreatic Cystic Neoplasms 5U01CA282272-03 Matthew Young, Ph.D.
Siminski, Suzanne M.

Frontier Sci & Technology Rsch Fdn, Inc
United States

CASCADE Coordinating Center 5U24CA275417-04 Maria Silvina Frech, Ph.D., M.S.
Singal, Amit

Ut Southwestern Medical Center
United States

Precision Risk Stratification and Screening for HCC among Patients with Cirrhosis in the United States 5U01CA230694-05
Singal, Amit

Ut Southwestern Medical Center
United States

Clinical Validation Center for Hepatocellular Carcinoma 5U01CA271887-04 Indu Kohaar, Ph.D., M.Phil., M.Sc.
Singal, Amit

Ut Southwestern Medical Center
United States

Precision Risk Stratification and Screening for HCC among Patients with Indeterminate Liver Nodules 4U01CA283935-03 Sidney Fu, M.D.
Singal, Amit

Ut Southwestern Medical Center
United States

Clinical Validation Center for Hepatocellular Carcinoma 5U01CA271887-04 Indu Kohaar, Ph.D., M.Phil., M.Sc.
Singal, Amit

Ut Southwestern Medical Center
United States

Precision Screening for Hepatocellular Carcinoma in Patients with Cirrhosis 5R01CA222900-06
Siskind, Leah J

University Of Louisville
United States

Protecting the kidney from cisplatin induced injury and progression to chronic kidney disease 1R01CA305985-01 Marjorie Perloff, M.D.
Siskind, Leah J

University Of Louisville
United States

Protecting the kidney from cisplatin induced injury and progression to chronic kidney disease 1R01CA305985-01 Marjorie Perloff, M.D.
Skates, Steven J

Massachusetts General Hospital
United States

Proteomic Analyses of Serial Prediagnostic PLCO Serum in Cases and Controls to Identify Early Detection Ovarian Cancer Biomarkers Rising in a Substantial Fraction of Cases and Stable in Most Controls 5U01CA260758-05 Claire Zhu, Ph.D.
Skates, Steven J

Massachusetts General Hospital
United States

Genome-wide methylation and proteomic analysis of uterine lavage and cervical swab for early detection of ovarian cancer 5U2CCA271871-03 Christos Patriotis, Ph.D., M.Sc.
Skubitz, Amy Patrice

University Of Minnesota
United States

A paradigm shift for ovarian cancer biomarkers: Utilizing routine Pap tests as liquid biopsies for the development of targeted mass spectrometry-based proteomic assays for early detection 5R01CA262153-05 Christos Patriotis, Ph.D., M.Sc.
Slager, Susan L

Mayo Clinic Rochester
United States

The genetic and epigenetic etiology of progression from the precursor state to chronic lymphocytic leukemia (CLL) 4R01CA258465-04 Nicholas Hodges, Ph.D.

Program Contact(s)

Sudhir Srivastava, Ph.D., M.P.H.
Email: sudhir.srivastava@nih.gov

Guillermo Marquez, Ph.D.
Email: guillermo.marquez@nih.gov