Program Official

Principal Investigator

Michael G.
Goggins
Awardee Organization

Johns Hopkins University
United States

Fiscal Year
2023
Activity Code
R01
Early Stage Investigator Grants (ESI)
Not Applicable
Project End Date

Using Markers to Improve Pancreatic Cancer Screening

Most patients with pancreatic cancer present with advanced incurable disease, but patients diagnosed with Stage I pancreatic cancer have a much better outcome. The early detection of pancreatic cancer requires simple and effective pancreatic screening tests that can be applied to high risk populations. The Cancer of the Pancreas Screening (CAPS) study currently follows a familial/genetic “high-risk” cohort of ~1000 patients undergo regular pancreatic surveillance. Recent results from the CAPS program indicate that pancreatic cancers detected during pancreatic surveillance are down-staged; 40% of those who maintained annual surveillance had a Stage I pancreatic cancer. These results indicate that early detection can improve overall outcome of patients with pancreatic cancer. Circulating tumor marker tests are not currently used for pancreas surveillance. Genetic factors are known to influence tumor marker levels, but gene tests have not been evaluated to determine if they could improve the accuracy of tumor markers. Recent studies from the PI's lab indicate that the normal reference ranges of commonly used tumor markers (CA19-9, CA-125 and CEA) are better defined by an individual's tumor marker genotype. A tumor marker genotype test can improve the diagnostic sensitivity of tumor markers at 99% specificity compared to conventional diagnostic cut-offs. We propose to establish genetically-defined normal reference ranges for tumor marker levels and evaluate their diagnostic accuracy in a prospective clinical trial of patients undergoing pancreatic imaging surveillance through our CAPS program. The addition of annual blood tests to pancreatic surveillance is expected to improve the detection of early-stage pancreatic cancer.

Publications

  • Ando Y, Goggins M. ASO Author Reflections: Using a CA19-9 Tumor Marker Gene Test to Assess Outcome after Pancreatic Cancer Surgery. Annals of surgical oncology. 2024 May;31(5):2961-2962. Epub 2024 Jan 27. PMID: 38280960
  • Furniss CS, Yurgelun MB, Ukaegbu C, Constantinou PE, Lafferty CC, Talcove-Berko ER, Schwartz AN, Stopfer JE, Underhill-Blazey M, Kenner B, Nelson SH, Okumura S, Law S, Zhou AY, Coffin TB, Rodriguez NJ, Uno H, Ocean AJ, McAllister F, Lowy AM, Lippman SM, Klein AP, Madlensky L, Petersen GM, Garber JE, Goggins MG, Maitra A, Syngal S. Novel Models of Genetic Education and Testing for Pancreatic Cancer Interception: Preliminary Results from the GENERATE Study. Cancer prevention research (Philadelphia, Pa.). 2021 Nov;14(11):1021-1032. Epub 2021 Oct 8. PMID: 34625409
  • Canto MI, Kerdsirichairat T, Yeo CJ, Hruban RH, Shin EJ, Almario JA, Blackford A, Ford M, Klein AP, Javed AA, Lennon AM, Zaheer A, Kamel IR, Fishman EK, Burkhart R, He J, Makary M, Weiss MJ, Schulick RD, Goggins MG, Wolfgang CL. Surgical Outcomes After Pancreatic Resection of Screening-Detected Lesions in Individuals at High Risk for Developing Pancreatic Cancer. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 2020 May;24(5):1101-1110. Epub 2019 Jun 13. PMID: 31197699
  • Katona BW, Brand RE, Canto MI, Chak A, Farrell JJ, Kastrinos F, Rustgi AK, Stoffel EM, Syngal S, Goggins M, CAPS5 Study Consortium. Screening for Pancreatic Ductal Adenocarcinoma: Are We Asking the Impossible?-Letter. Cancer prevention research (Philadelphia, Pa.). 2021 Oct;14(10):973-974. PMID: 34607877
  • Hata T, Suenaga M, Marchionni L, Macgregor-Das A, Yu J, Shindo K, Tamura K, Hruban RH, Goggins M. Genome-Wide Somatic Copy Number Alterations and Mutations in High-Grade Pancreatic Intraepithelial Neoplasia. The American journal of pathology. 2018 Jul;188(7):1723-1733. Epub 2018 Apr 22. PMID: 29684357
  • Dbouk M, Katona BW, Brand RE, Chak A, Syngal S, Farrell JJ, Kastrinos F, Stoffel EM, Canto MI, Goggins M. Reply to S. Raoof. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2023 Feb 10;41(5):1147-1149. Epub 2022 Oct 31. PMID: 36315911
  • Goggins M, Overbeek KA, Brand R, Syngal S, Del Chiaro M, Bartsch DK, Bassi C, Carrato A, Farrell J, Fishman EK, Fockens P, Gress TM, van Hooft JE, Hruban RH, Kastrinos F, Klein A, Lennon AM, Lucas A, Park W, Rustgi A, Simeone D, Stoffel E, Vasen HFA, Cahen DL, Canto MI, Bruno M, International Cancer of the Pancreas Screening (CAPS) consortium, Arcidiacono PG, Ashida R, Ausems M, Besselink M, Biermann K, Bonsing B, Brentnall T, Chak A, Early D, Castillo CF, Frucht H, Furukawa T, Gallinger S, Geurts J, Koerkamp BG, Hammel P, Hes F, Iglesias-Garcia J, Kamel I, Kitano M, Klöppel G, Krak N, Kurtz R, Kwon R, Lachter J, Lee J, Levy M, Malleo G, Meguid C, Maitra A, Margolis D, Offerhaus J, Olson S, Paiella S, Park W, Petersen G, Poley JW, Real FX, Saltzman J, Schulick R, Stoita A, Takaori K, Tanaka M, Tamm E, Topazian M, Vazquez-Sequeiros E, Vleggaar F, Vos Tot Nederveen Cappel W, Yeo C, Wasser M, Wagner A, Wallace M, Wolfgang C, Wood L. Management of patients with increased risk for familial pancreatic cancer: updated recommendations from the International Cancer of the Pancreas Screening (CAPS) Consortium. Gut. 2020 Jan;69(1):7-17. Epub 2019 Oct 31. PMID: 31672839
  • Suenaga M, Sadakari Y, Almario JA, Borges M, Lennon AM, Shin EJ, Canto MI, Goggins M. Using an endoscopic distal cap to collect pancreatic fluid from the ampulla (with video). Gastrointestinal endoscopy. 2017 Dec;86(6):1152-1156.e2. Epub 2017 Mar 1. PMID: 28259593
  • Akshintala VS, Talukdar R, Singh VK, Goggins M. The Gut Microbiome in Pancreatic Disease. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2019 Jan;17(2):290-295. Epub 2018 Aug 23. PMID: 30144522
  • Kawamoto M, Yoshida T, Tamura K, Dbouk M, Canto MI, Burkhart R, He J, Roberts NJ, Klein AP, Goggins M. Endoplasmic stress-inducing variants in carboxyl ester lipase and pancreatic cancer risk. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]. 2022 Nov;22(7):959-964. Epub 2022 Aug 17. PMID: 35995657
  • Raman A, Lennon AM. Cyst Fluid Biomarkers - Diagnosis and Prediction of Malignancy for Cystic Lesions of the Pancreas. Visceral medicine. 2018 Jul;34(3):178-181. Epub 2018 Jun 13. PMID: 30140682
  • Dal Molin M, Brant A, Blackford AL, Griffin JF, Shindo K, Barkley T, Rezaee N, Hruban RH, Wolfgang CL, Goggins M. Obstructive Sleep Apnea and Pathological Characteristics of Resected Pancreatic Ductal Adenocarcinoma. PloS one. 2016 Oct 12;11(10):e0164195. doi: 10.1371/journal.pone.0164195. eCollection 2016. PMID: 27732623
  • Ando Y, Dbouk M, Yoshida T, Saba H, Abou Diwan E, Yoshida K, Dbouk A, Blackford AL, Lin MT, Lennon AM, Burkhart RA, He J, Sokoll L, Eshleman JR, Canto MI, Goggins M. Using Tumor Marker Gene Variants to Improve the Diagnostic Accuracy of DUPAN-2 and Carbohydrate Antigen 19-9 for Pancreatic Cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2024 Jun 20;42(18):2196-2206. Epub 2024 Mar 8. PMID: 38457748
  • Maker AV, Carrara S, Jamieson NB, Pelaez-Luna M, Lennon AM, Dal Molin M, Scarpa A, Frulloni L, Brugge WR. Cyst fluid biomarkers for intraductal papillary mucinous neoplasms of the pancreas: a critical review from the international expert meeting on pancreatic branch-duct-intraductal papillary mucinous neoplasms. Journal of the American College of Surgeons. 2015 Feb;220(2):243-53. Epub 2014 Nov 6. PMID: 25592469
  • Saba H, Goggins M. Familial Pancreatic Cancer. Gastroenterology clinics of North America. 2022 Sep;51(3):561-575. Epub 2022 Aug 29. PMID: 36153110
  • Dbouk M, Abe T, Koi C, Ando Y, Saba H, Abou Diwan E, MacGregor-Das A, Blackford AL, Mocci E, Beierl K, Dbouk A, He J, Burkhart R, Lennon AM, Sokoll L, Canto MI, Eshleman JR, Goggins M. Diagnostic Performance of a Tumor Marker Gene Test to Personalize Serum CA19-9 Reference Ranges. Clinical cancer research : an official journal of the American Association for Cancer Research. 2023 Oct 13;29(20):4178-4185. PMID: 37566230
  • Ando Y, Dbouk M, Blackford AL, Yoshida T, Saba H, Abou Diwan E, Yoshida K, Sokoll L, Eshleman JR, Burkhart R, He J, Goggins M. Using a CA19-9 Tumor Marker Gene Test to Assess Outcome After Pancreatic Cancer Surgery. Annals of surgical oncology. 2024 May;31(5):2902-2912. Epub 2024 Feb 6. PMID: 38319515
  • Hata T, Dal Molin M, Suenaga M, Yu J, Pittman M, Weiss M, Canto MI, Wolfgang C, Lennon AM, Hruban RH, Goggins M. Cyst Fluid Telomerase Activity Predicts the Histologic Grade of Cystic Neoplasms of the Pancreas. Clinical cancer research : an official journal of the American Association for Cancer Research. 2016 Oct 15;22(20):5141-5151. Epub 2016 May 26. PMID: 27230749
  • Tamura K, Yu J, Hata T, Suenaga M, Shindo K, Abe T, MacGregor-Das A, Borges M, Wolfgang CL, Weiss MJ, He J, Canto MI, Petersen GM, Gallinger S, Syngal S, Brand RE, Rustgi A, Olson SH, Stoffel E, Cote ML, Zogopoulos G, Potash JB, Goes FS, McCombie RW, Zandi PP, Pirooznia M, Kramer M, Parla J, Eshleman JR, Roberts NJ, Hruban RH, Klein AP, Goggins M. Mutations in the pancreatic secretory enzymes CPA1 and CPB1 are associated with pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America. 2018 May 1;115(18):4767-4772. Epub 2018 Apr 18. PMID: 29669919
  • Katona BW, Mahmud N, Dbouk M, Ahmad N, Chhoda A, Dudley B, Hayat U, Kwon RS, Lee LS, Rustgi AK, Ukaegbu C, Vasquez L, Volk S, Brand RE, Canto MI, Chak A, Farrell JJ, Kastrinos F, Stoffel EM, Syngal S, Goggins M. COVID-19 related pancreatic cancer surveillance disruptions amongst high-risk individuals. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]. 2021 Apr 20;21(6):1048-51. Epub 2021 Apr 20. PMID: 33926820
  • Wood LD, Yurgelun MB, Goggins MG. Genetics of Familial and Sporadic Pancreatic Cancer. Gastroenterology. 2019 May;156(7):2041-2055. Epub 2019 Jan 18. PMID: 30660730
  • Robinson C, Estrada A, Zaheer A, Singh VK, Wolfgang CL, Goggins MG, Hruban RH, Wood LD, Noë M, Montgomery EA, Guthrie LC, Lennon AM, Boyce AM, Collins MT. Clinical and Radiographic Gastrointestinal Abnormalities in McCune-Albright Syndrome. The Journal of clinical endocrinology and metabolism. 2018 Nov 1;103(11):4293-4303. PMID: 30124968
  • Dal Molin M, Kim H, Blackford A, Sharma R, Goggins M. Glucagon-Like Peptide-1 Receptor Expression in Normal and Neoplastic Human Pancreatic Tissues. Pancreas. 2016 Apr;45(4):613-9. PMID: 26495786
  • Aijazi M, Fasanella KE, McGrath K, Smith LM, Singhi AD, Brand RE. Pancreatic Cysts Greater Than 1 cm Are Associated With an Increased Risk for Developing Pancreatic Cancer in Individuals From Pancreatic-Cancer Prone Kindreds Undergoing Surveillance. Pancreas. 2024 Apr 1;53(4):e350-e356. Epub 2024 Mar 13. PMID: 38518061
  • Abe T, Blackford AL, Tamura K, Ford M, McCormick P, Chuidian M, Almario JA, Borges M, Lennon AM, Shin EJ, Klein AP, Hruban RH, Canto MI, Goggins M. Deleterious Germline Mutations Are a Risk Factor for Neoplastic Progression Among High-Risk Individuals Undergoing Pancreatic Surveillance. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2019 May 1;37(13):1070-1080. Epub 2019 Mar 18. PMID: 30883245
  • Rastegar N, Matteoni-Athayde LG, Eng J, Takahashi N, Tamm EP, Mortele KJ, Syngal S, Margolis D, Lennon AM, Wolfgang CL, Fishman EK, Hruban RH, Goggins M, Canto MI, Kamel IR. Incremental value of secretin-enhanced magnetic resonance cholangiopancreatography in detecting ductal communication in a population with high prevalence of small pancreatic cysts. European journal of radiology. 2015 Apr;84(4):575-80. Epub 2015 Jan 13. PMID: 25619503
  • Sadakari Y, Kanda M, Maitani K, Borges M, Canto MI, Goggins M. Mutant KRAS and GNAS DNA Concentrations in Secretin-Stimulated Pancreatic Fluid Collected from the Pancreatic Duct and the Duodenal Lumen. Clinical and translational gastroenterology. 2014 Nov 13;5(11):e62. PMID: 25393586
  • Shindo K, Yu J, Suenaga M, Fesharakizadeh S, Cho C, Macgregor-Das A, Siddiqui A, Witmer PD, Tamura K, Song TJ, Navarro Almario JA, Brant A, Borges M, Ford M, Barkley T, He J, Weiss MJ, Wolfgang CL, Roberts NJ, Hruban RH, Klein AP, Goggins M. Deleterious Germline Mutations in Patients With Apparently Sporadic Pancreatic Adenocarcinoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2017 Oct 20;35(30):3382-3390. Epub 2017 Aug 2. PMID: 28767289
  • Poruk KE, Griffin J, Makary MA, He J, Cameron JL, Weiss MJ, Wood LD, Goggins M, Wolfgang CL. Blood Type as a Predictor of High-Grade Dysplasia and Associated Malignancy in Patients with Intraductal Papillary Mucinous Neoplasms. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 2019 Mar;23(3):477-483. Epub 2018 Sep 4. PMID: 30187322
  • Kim H, Saka B, Knight S, Borges M, Childs E, Klein A, Wolfgang C, Herman J, Adsay VN, Hruban RH, Goggins M. Having pancreatic cancer with tumoral loss of ATM and normal TP53 protein expression is associated with a poorer prognosis. Clinical cancer research : an official journal of the American Association for Cancer Research. 2014 Apr 1;20(7):1865-72. Epub 2014 Jan 31. PMID: 24486587
  • Pea A, Yu J, Rezaee N, Luchini C, He J, Dal Molin M, Griffin JF, Fedor H, Fesharakizadeh S, Salvia R, Weiss MJ, Bassi C, Cameron JL, Zheng L, Scarpa A, Hruban RH, Lennon AM, Goggins M, Wolfgang CL, Wood LD. Targeted DNA Sequencing Reveals Patterns of Local Progression in the Pancreatic Remnant Following Resection of Intraductal Papillary Mucinous Neoplasm (IPMN) of the Pancreas. Annals of surgery. 2017 Jul;266(1):133-141. PMID: 27433916
  • Hata T, Dal Molin M, Hong SM, Tamura K, Suenaga M, Yu J, Sedogawa H, Weiss MJ, Wolfgang CL, Lennon AM, Hruban RH, Goggins MG. Predicting the Grade of Dysplasia of Pancreatic Cystic Neoplasms Using Cyst Fluid DNA Methylation Markers. Clinical cancer research : an official journal of the American Association for Cancer Research. 2017 Jul 15;23(14):3935-3944. Epub 2017 Feb 1. PMID: 28148542
  • Canto MI, Almario JA, Schulick RD, Yeo CJ, Klein A, Blackford A, Shin EJ, Sanyal A, Yenokyan G, Lennon AM, Kamel IR, Fishman EK, Wolfgang C, Weiss M, Hruban RH, Goggins M. Risk of Neoplastic Progression in Individuals at High Risk for Pancreatic Cancer Undergoing Long-term Surveillance. Gastroenterology. 2018 Sep;155(3):740-751.e2. Epub 2018 May 24. PMID: 29803839
  • Yoshida T, Dbouk M, Hirose K, Abou Diwan E, Saba H, Dbouk A, Goggins M. Duodenal and pancreatic tissue microbiome profiles of PPI users and non-users. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]. 2024 Feb;24(1):188-195. Epub 2023 Dec 27. PMID: 38161092
  • Suenaga M, Yu J, Shindo K, Tamura K, Almario JA, Zaykoski C, Witmer PD, Fesharakizadeh S, Borges M, Lennon AM, Shin EJ, Canto MI, Goggins M. Pancreatic Juice Mutation Concentrations Can Help Predict the Grade of Dysplasia in Patients Undergoing Pancreatic Surveillance. Clinical cancer research : an official journal of the American Association for Cancer Research. 2018 Jun 15;24(12):2963-2974. Epub 2018 Jan 4. PMID: 29301828
  • Ayars M, O'Sullivan E, Macgregor-Das A, Shindo K, Kim H, Borges M, Yu J, Hruban RH, Goggins M. IL2RG, identified as overexpressed by RNA-seq profiling of pancreatic intraepithelial neoplasia, mediates pancreatic cancer growth. Oncotarget. 2017 Aug 3;8(48):83370-83383. doi: 10.18632/oncotarget.19848. eCollection 2017 Oct 13. PMID: 29137350
  • Abe T, Koi C, Kohi S, Song KB, Tamura K, Macgregor-Das A, Kitaoka N, Chuidian M, Ford M, Dbouk M, Borges M, He J, Burkhart R, Wolfgang CL, Klein AP, Eshleman JR, Hruban RH, Canto MI, Goggins M. Gene Variants That Affect Levels of Circulating Tumor Markers Increase Identification of Patients With Pancreatic Cancer. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2020 May;18(5):1161-1169.e5. Epub 2019 Oct 30. PMID: 31676359
  • Kohi S, Macgregor-Das A, Dbouk M, Yoshida T, Chuidian M, Abe T, Borges M, Lennon AM, Shin EJ, Canto MI, Goggins M. Alterations in the Duodenal Fluid Microbiome of Patients With Pancreatic Cancer. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2022 Feb;20(2):e196-e227. Epub 2020 Nov 5. PMID: 33161160
  • Shindo K, Yu J, Suenaga M, Fesharakizadeh S, Tamura K, Almario JAN, Brant A, Borges M, Siddiqui A, Datta L, Wolfgang CL, Hruban RH, Klein AP, Goggins M. Lack of association between the pancreatitis risk allele CEL-HYB and pancreatic cancer. Oncotarget. 2017 Feb 7;8(31):50824-50831. doi: 10.18632/oncotarget.15137. eCollection 2017 Aug 1. PMID: 28881607
  • Lennon AM, Canto MI. Pancreatic Cysts - Part 2: Should We Be Less Cyst Centric? Pancreas. 2017 Jul;46(6):745-750. PMID: 28609361
  • Rodriguez NJ, Furniss CS, Yurgelun MB, Ukaegbu C, Constantinou PE, Fortes I, Caruso A, Schwartz AN, Stopfer JE, Underhill-Blazey M, Kenner B, Nelson SH, Okumura S, Zhou AY, Coffin TB, Uno H, Horiguchi M, Ocean AJ, McAllister F, Lowy AM, Klein AP, Madlensky L, Petersen GM, Garber JE, Lippman SM, Goggins MG, Maitra A, Syngal S. A Randomized Trial of Two Remote Health Care Delivery Models on the Uptake of Genetic Testing and Impact on Patient-Reported Psychological Outcomes in Families With Pancreatic Cancer: The Genetic Education, Risk Assessment, and Testing (GENERATE) Study. Gastroenterology. 2024 May;166(5):872-885.e2. Epub 2024 Feb 5. PMID: 38320723
  • Kawamoto M, Kohi S, Abe T, Dbouk M, Macgregor-Das A, Koi C, Song KB, Borges M, Sugimine R, Laheru D, Hruban RH, Roberts N, Klein AP, Goggins M. Endoplasmic stress-inducing variants in CPB1 and CPA1 and risk of pancreatic cancer: A case-control study and meta-analysis. International journal of cancer. 2022 Apr 1;150(7):1123-1133. Epub 2021 Dec 6. PMID: 34817877
  • Amato E, Molin MD, Mafficini A, Yu J, Malleo G, Rusev B, Fassan M, Antonello D, Sadakari Y, Castelli P, Zamboni G, Maitra A, Salvia R, Hruban RH, Bassi C, Capelli P, Lawlor RT, Goggins M, Scarpa A. Targeted next-generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas. The Journal of pathology. 2014 Jul;233(3):217-27. PMID: 24604757
  • Hosoda W, Chianchiano P, Griffin JF, Pittman ME, Brosens LA, Noë M, Yu J, Shindo K, Suenaga M, Rezaee N, Yonescu R, Ning Y, Albores-Saavedra J, Yoshizawa N, Harada K, Yoshizawa A, Hanada K, Yonehara S, Shimizu M, Uehara T, Samra JS, Gill AJ, Wolfgang CL, Goggins MG, Hruban RH, Wood LD. Genetic analyses of isolated high-grade pancreatic intraepithelial neoplasia (HG-PanIN) reveal paucity of alterations in TP53 and SMAD4. The Journal of pathology. 2017 May;242(1):16-23. Epub 2017 Mar 30. PMID: 28188630
  • Dbouk M, Katona BW, Brand RE, Chak A, Syngal S, Farrell JJ, Kastrinos F, Stoffel EM, Blackford AL, Rustgi AK, Dudley B, Lee LS, Chhoda A, Kwon R, Ginsberg GG, Klein AP, Kamel I, Hruban RH, He J, Shin EJ, Lennon AM, Canto MI, Goggins M. The Multicenter Cancer of Pancreas Screening Study: Impact on Stage and Survival. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2022 Oct 1;40(28):3257-3266. Epub 2022 Jun 15. PMID: 35704792
  • Poruk KE, Blackford AL, Weiss MJ, Cameron JL, He J, Goggins M, Rasheed ZA, Wolfgang CL, Wood LD. Circulating Tumor Cells Expressing Markers of Tumor-Initiating Cells Predict Poor Survival and Cancer Recurrence in Patients with Pancreatic Ductal Adenocarcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2017 Jun 1;23(11):2681-2690. Epub 2016 Oct 27. PMID: 27789528
  • Yu J, Blackford AL, Dal Molin M, Wolfgang CL, Goggins M. Time to progression of pancreatic ductal adenocarcinoma from low-to-high tumour stages. Gut. 2015 Nov;64(11):1783-9. Epub 2015 Jan 30. PMID: 25636698
  • Yu J, Sadakari Y, Shindo K, Suenaga M, Brant A, Almario JAN, Borges M, Barkley T, Fesharakizadeh S, Ford M, Hruban RH, Shin EJ, Lennon AM, Canto MI, Goggins M. Digital next-generation sequencing identifies low-abundance mutations in pancreatic juice samples collected from the duodenum of patients with pancreatic cancer and intraductal papillary mucinous neoplasms. Gut. 2017 Sep;66(9):1677-1687. Epub 2016 Jul 18. PMID: 27432539
  • Biller LH, Wolpin BM, Goggins M. Inherited Pancreatic Cancer Syndromes and High-Risk Screening. Surgical oncology clinics of North America. 2021 Oct;30(4):773-786. Epub 2021 Jul 22. PMID: 34511196
  • Ayars M, Goggins M. Pancreatic cancer: Classifying pancreatic cancer using gene expression profiling. Nature reviews. Gastroenterology & hepatology. 2015 Nov;12(11):613-4. Epub 2015 Oct 20. PMID: 26484444
  • Mazer BL, Lee JW, Roberts NJ, Chu LC, Lennon AM, Klein AP, Eshleman JR, Fishman EK, Canto MI, Goggins MG, Hruban RH. Screening for pancreatic cancer has the potential to save lives, but is it practical? Expert review of gastroenterology & hepatology. 2023 Jan-Jun;17(6):555-574. Epub 2023 Jul 3. PMID: 37212770
  • Blackford AL, Canto MI, Klein AP, Hruban RH, Goggins M. Recent Trends in the Incidence and Survival of Stage 1A Pancreatic Cancer: A Surveillance, Epidemiology, and End Results Analysis. Journal of the National Cancer Institute. 2020 Nov 1;112(11):1162-1169. PMID: 31958122
  • Macgregor-Das A, Yu J, Tamura K, Abe T, Suenaga M, Shindo K, Borges M, Koi C, Kohi S, Sadakari Y, Dal Molin M, Almario JA, Ford M, Chuidian M, Burkhart R, He J, Hruban RH, Eshleman JR, Klein AP, Wolfgang CL, Canto MI, Goggins M. Detection of Circulating Tumor DNA in Patients with Pancreatic Cancer Using Digital Next-Generation Sequencing. The Journal of molecular diagnostics : JMD. 2020 Jun;22(6):748-756. Epub 2020 Mar 20. PMID: 32205290
  • Law JK, Ahmed A, Singh VK, Akshintala VS, Olson MT, Raman SP, Ali SZ, Fishman EK, Kamel I, Canto MI, Dal Molin M, Moran RA, Khashab MA, Ahuja N, Goggins M, Hruban RH, Wolfgang CL, Lennon AM. A systematic review of solid-pseudopapillary neoplasms: are these rare lesions? Pancreas. 2014 Apr;43(3):331-7. PMID: 24622060
  • Hata T, Dal Molin M, McGregor-Das A, Song TJ, Wolfgang C, Eshleman JR, Hruban RH, Goggins M. Simple Detection of Telomere Fusions in Pancreatic Cancer, Intraductal Papillary Mucinous Neoplasm, and Pancreatic Cyst Fluid. The Journal of molecular diagnostics : JMD. 2018 Jan;20(1):46-55. Epub 2017 Dec 8. PMID: 29229290
  • Tie J, Wang Y, Cohen J, Li L, Hong W, Christie M, Wong HL, Kosmider S, Wong R, Thomson B, Choi J, Fox A, Field K, Burge M, Shannon J, Kotasek D, Tebbutt NC, Karapetis C, Underhill C, Haydon A, Schaeffer J, Ptak J, Tomasetti C, Papadopoulos N, Kinzler KW, Vogelstein B, Gibbs P. Circulating tumor DNA dynamics and recurrence risk in patients undergoing curative intent resection of colorectal cancer liver metastases: A prospective cohort study. PLoS medicine. 2021 May 3;18(5):e1003620. doi: 10.1371/journal.pmed.1003620. eCollection 2021 May. PMID: 33939694
  • Eshleman JR, Norris AL, Sadakari Y, Debeljak M, Borges M, Harrington C, Lin E, Brant A, Barkley T, Almario JA, Topazian M, Farrell J, Syngal S, Lee JH, Yu J, Hruban RH, Kanda M, Canto MI, Goggins M. KRAS and guanine nucleotide-binding protein mutations in pancreatic juice collected from the duodenum of patients at high risk for neoplasia undergoing endoscopic ultrasound. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2015 May;13(5):963-9.e4. Epub 2014 Dec 4. PMID: 25481712
  • Shin EJ, Topazian M, Goggins MG, Syngal S, Saltzman JR, Lee JH, Farrell JJ, Canto MI. Linear-array EUS improves detection of pancreatic lesions in high-risk individuals: a randomized tandem study. Gastrointestinal endoscopy. 2015 Nov;82(5):812-8. Epub 2015 Apr 27. PMID: 25930097
  • Pozzessere C, Castaños Gutiérrez SL, Corona-Villalobos CP, Righi L, Xu C, Lennon AM, Wolfgang CL, Hruban RH, Goggins M, Canto MI, Kamel IR. Diffusion-Weighted Magnetic Resonance Imaging in Distinguishing Between Mucin-Producing and Serous Pancreatic Cysts. Journal of computer assisted tomography. 2016 Jul-Aug;40(4):505-12. PMID: 27023856
  • Tanaka H, Tamura K, Abe T, Yoshida T, Macgregor-Das A, Dbouk M, Blackford AL, Borges M, Lennon AM, He J, Burkhart R, Canto MI, Goggins M. Serum Carboxypeptidase Activity and Genotype-Stratified CA19-9 to Detect Early-Stage Pancreatic Cancer. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2022 Oct;20(10):2267-2275.e2. Epub 2021 Oct 12. PMID: 34648951
  • Tie J, Cohen JD, Lo SN, Wang Y, Li L, Christie M, Lee M, Wong R, Kosmider S, Skinner I, Wong HL, Lee B, Burge ME, Yip D, Karapetis CS, Price TJ, Tebbutt NC, Haydon AM, Ptak J, Schaeffer MJ, Silliman N, Dobbyn L, Popoli M, Tomasetti C, Papadopoulos N, Kinzler KW, Vogelstein B, Gibbs P. Prognostic significance of postsurgery circulating tumor DNA in nonmetastatic colorectal cancer: Individual patient pooled analysis of three cohort studies. International journal of cancer. 2021 Feb 15;148(4):1014-1026. Epub 2020 Oct 6. PMID: 32984952
  • Goggins M. The role of biomarkers in the early detection of pancreatic cancer. Familial cancer. 2024 Apr 25. Epub 2024 Apr 25. PMID: 38662265
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Clinical Trials

Study Name Clinical Trial ID
The Cancer of the Pancreas Screening-5 CAPS5)Study NCT02000089