Principal Investigator

Paige L
Williams
Awardee Organization

Harvard School Of Public Health
United States

Fiscal Year
2023
Activity Code
P01
Early Stage Investigator Grants (ESI)
Not Applicable
Project End Date

Pediatric HIV/AIDS Cohort Study (PHACS) 2020

Each year, there are more than 1 million pregnant women living with HIV (PWLHIV) who receive antiretroviral medications (ARVs) for treatment and perinatal and postnatal HIV transmission prevention, with new ARVs introduced at a rapid pace. Although maternal use of ARVs has successfully reduced perinatal HIV transmission, there remains a clear need to monitor the safety of in utero ARV for infant and child health. Currently, 1.7 million children under the age of 15 are living with HIV globally – the vast majority with perinatally acquired HIV infection (PHIV) - who are aging into young adulthood. In the US, the Centers for Disease Control and Prevention (CDC) estimates that in 2016, there were 11,915 persons with PHIV in the U.S, including 1,814 children younger than 13 years of age and 10,101 adolescents and young adults. The lifelong impact of HIV and ARVs on their overall health is unknown as they transition into adulthood and adult HIV care. The Pediatric HIV/AIDS Cohort Study (PHACS) is a network, initiated in 2007, currently consisting of two prospective cohort studies: The Surveillance Monitoring for ART Toxicities Study (SMARTT), with over 4,000 infants, children and youth with perinatal HIV exposure but who are uninfected (PHEU), and the series of Adolescent Master Protocols (AMP, AMP Up and AMP Up Lite) studies following 1,000 young adults with perinatal HIV, and a comparison cohort of young adults with PHEU. These studies are designed to answer questions regarding the short and long term outcomes of HIV infection and ARV exposure or treatment. PHACS 2020 is designed as a Program Project P01 grant, consisting of the following four support Cores: Scientific Administrative Core (SAC), Data Resources Core (DRC), Health Education and Community Core (HECC), and the Epidemiological and Statistical Methods Core (ESC) to provide scientific, site and cohort infrastructure, data management and analysis, health education and community input, as well as epidemiological and statistical support to four Research Projects: 1) SMARTT; 2) The Adolescent Master Protocol (AMP) Up Series (the AMP Up Series); 3) Natural History of Cervical Intraepithelial Neoplasia (CIN) and Human Papillomavirus (HPV) in HPV Vaccinated Youth with PHIV (HPV); and the TERBO BRAIN Study: Trajectories of Emotional Regulation and Behavior Outcomes and related Brain Regions And Intrinsic Networks (TERBO BRAIN). This multidisciplinary, interdisciplinary, transdisciplinary and synergistic P01 will address the most critical scientific questions for children, youth and young adults exposed to or living with HIV.

Publications

  • Yee LM, Jacobson DL, Haddad LB, Jao J, Powis KM, Kacanek D, Zash R, DiPerna A, Chadwick EG, Pediatric HIV/AIDS Cohort Study. Evaluating the association of antiretroviral therapy and immune status with hypertensive disorders of pregnancy among people with HIV. AIDS (London, England). 2023 Sep 1;37(11):1715-1723. Epub 2023 May 23. PMID: 37260289
  • Patel K, Huo Y, Jao J, Powis KM, Williams PL, Kacanek D, Yee LM, Chadwick EG, Shiau S, Jacobson DL, Brummel SS, Sultan-Beyer L, Kahlert CR, Zash R, Seage GR 3rd, Pediatric HIV/AIDS Cohort Study, Swiss Mother and Child HIV Cohort Study, D'Angelo J, Sanders MA, Malee K, Paul M, Eser-Jose R, McMullen-Jackson C, Harris L, Purswani M, Baig MM, Villegas A, Alvarado M, Robinson LG, Cooley JD, Blood J, Garvie P, Frederick T, Davtyan M, Morales-Avendano G, Borkowsky W, Deygoo NS, Lewis J, Dieudonne A, Bettica L, Johnson J, Surowiec K, Knapp K, Russell-Bell J, Wilkins M, Love S, Rosario N, Angeli-Nieves L, Olivera V, Kohlhoff S, Dennie A, Kaye J, Wallier J, Craig K, Van Dyke R, Sirois P, Hutto C, Hickman P, Huldtquist J, Marullo D, Spector SA, Figueroa V, Loughran M, Nichols S, McFarland E, Kwon C, Glenny C, Englund J, Rathore M, Mahmoudi S, El-Hassan S, Tejan J, Hayani K, Richardson L, Smith R, Miller A, Scott G, Gil Garcia G, Fernandez G, Cuadra A, Rodriguez ZM, Torres L, Scalley N, Abela I, Aebi-Popp K, Anagnostopoulos A, Battegay M, Baumann M, Bernasconi E, Braun DL, Bucher HC, Calmy A, Cavassini M, Ciuffi A, Crisinel PA, Darling K, Duppenthaler A, Egger M, Elzi L, Fehr J, Fellay J, Francini K, Furrer H, Fux CA, Günthard HF, Hachfeld A, Haerry D, Hasse B, Hirsch HH, Hoffmann M, Hösli I, Huber M, Kahlert CR, Kaiser L, Keiser O, Klimkait T, Kottanattu L, Kouyos RD, Kovari H, Kusejko K, Martinetti G, Martinez de Tejada B, Marzolini C, Metzner KJ, Müller N, Nemeth J, Nicca D, Paioni P, Pantaleo G, Perreau M, Polli C, Rauch A, Ritz N, Schmid P, Speck R, Stöckle M, Sultan-Beyer L, Tarr P, Lecompte MT, Trkola A, Wagner N, Wandeler G, Yerly S. Dolutegravir in Pregnancy as Compared with Current HIV Regimens in the United States. The New England journal of medicine. 2022 Sep 1;387(9):799-809. PMID: 36053505
  • Nichols SL, Brummel S, Malee KM, Mellins CA, Moscicki AB, Smith R, Cuadra AM, Bryant K, Boyce CA, Tassiopoulos KK, Pediatric HIV/AIDS Cohort Study. The Role of Behavioral and Neurocognitive Functioning in Substance Use Among Youth with Perinatally Acquired HIV Infection and Perinatal HIV Exposure Without Infection. AIDS and behavior. 2021 Sep;25(9):2827-2840. Epub 2021 Feb 22. PMID: 33616833
  • Rawat P, Brummel SS, Singh KK, Kim J, Frazer KA, Nichols S, Seage GR, Williams PL, Van Dyke RB, Harismendy O, Trout RN, Spector SA. Genomics Links Inflammation With Neurocognitive Impairment in Children Living With Human Immunodeficiency Virus Type-1. The Journal of infectious diseases. 2021 Sep 1;224(5):870-880. PMID: 33373444
  • Bather JR, Horton NJ, Coull BA, Williams PL. The impact of correlated exposures and missing data on multiple informant models used to identify critical exposure windows. Statistics in medicine. 2023 Apr 15;42(8):1171-1187. Epub 2023 Jan 16. PMID: 36647625
  • Yao TJ, Malee K, Zhang J, Smith R, Redmond S, Rice ML, Frederick T, Torre P, Mellins CA, Hoffman HJ, Williams PL. In Utero Antiretroviral Exposure and Risk of Neurodevelopmental Problems in HIV-Exposed Uninfected 5-Year-Old Children. AIDS patient care and STDs. 2023 Mar;37(3):119-130. Epub 2023 Feb 24. PMID: 36827595
  • Smith C, Fought AJ, Sung JF, McKinney JR, Metz TD, Fetters KB, Lazarus S, Capraro S, Barr E, Glenny C, Buehler J, Weinberg A, CHIP Perinatal Medical Team. Congenital malformations and preeclampsia associated with integrase inhibitor use in pregnancy: A single-center analysis. PloS one. 2023 Jun 12;18(6):e0276473. doi: 10.1371/journal.pone.0276473. eCollection 2023. PMID: 37307279
  • Brummel SS, Van Dyke RB, Patel K, Purswani M, Seage GR, Yao TJ, Hazra R, Karalius B, Williams PL, Pediatric HIV/AIDS Cohort Study. Analyzing Longitudinally Collected Viral Load Measurements in Youth With Perinatally Acquired HIV Infection: Problems and Possible Remedies. American journal of epidemiology. 2022 Sep 28;191(10):1820-1830. PMID: 35872591
  • Shiau S, Yu W, Jacobson DL, Nichols S, McFarland EJ, Chen JS, Dirajlal-Fargo S, Surowiec K, Geffner ME, Jao J, Pediatric HIV/AIDS Cohort Study. Components of metabolic syndrome associated with lower neurocognitive performance in youth with perinatally acquired HIV and youth who are HIV-exposed uninfected. Journal of neurovirology. 2021 Oct;27(5):702-715. Epub 2021 Sep 15. PMID: 34524627
  • Sirois PA, Huo Y, Nozyce ML, Garvie PA, Harris LL, Malee K, McEvoy R, Mellins CA, Nichols SL, Smith R, Tassiopoulos K, Pediatric HIV/AIDS Cohort Study. Ageing with HIV: a longitudinal study of markers of resilience in young adults with perinatal exposure to HIV, with or without perinatally acquired HIV. Journal of the International AIDS Society. 2022 Sep;25 Suppl 4(Suppl 4):e25982. PMID: 36176020
  • Jacobson DL, Neri D, Gaskins A, Yee L, Mendez AJ, Hendricks K, Siminski S, Zash R, Hyzy L, Jao J, Pediatric HIV/AIDS Cohort Study, J DL, G A, Y L, H K, Z R, J J, N D, M AJ, S S, H L. Maternal anemia and preterm birth among women living with HIV in the United States. The American journal of clinical nutrition. 2021 Jun 1;113(6):1402-1410. PMID: 35104854
  • Shiau S, Jacobson DL, Huo Y, Kacanek D, Yee LM, Williams DB, Haddad LB, Serghides L, Powis K, Sperling RS, Williams PL, Jao J, Pediatric HIV/AIDS Cohort Study, Chadwick E, Sanders MA, Malee K, Paul M, Eser-Jose R, McMullen-Jackson C, Harris L, Purswani M, Baig MM, Villegas A, Alvarado M, Robinson LG, Cooley JD, Blood J, Garvie P, Borkowsky W, Deygoo NS, Lewis J, Dieudonne A, Bettica L, Johnson J, Surowiec K, Knapp K, Russell-Bell J, Wilkins M, Love S, Rosario N, Angeli-Nieves L, Olivera V, Kohlhoff S, Dennie A, Kaye J, Wallier J, Craig K, Silio M, Sirois P, Hutto C, Hickman P, Huldtquist J, Marullo D, Spector SA, Figueroa V, Loughran M, Nichols S, McFarland E, Kwon C, Glenny C, Englund J, Rathore M, Mahmoudi S, El-Hassan S, Tejan J, Hayani K, Richardson L, Smith R, Miller A, Scott G, Garcia GG, Fernandez G, Cuadra A, Frederick T, Davtyan M, Morales-Avendano G, Rodriguez ZM, Torres L, Scalley N. Unique Profile of Inflammation and Immune Activation in Pregnant People With HIV in the United States. The Journal of infectious diseases. 2023 Mar 1;227(5):720-730. PMID: 36592383
  • Dirajlal-Fargo S, Jacobson DL, Yu W, Mirza A, Geffner ME, Mccomsey GA, Jao J, Pediatric HIV/AIDS Cohort Study (PHACS). Longitudinal changes in body fat and metabolic complications in young people with perinatally acquired HIV. HIV medicine. 2024 Feb;25(2):233-244. Epub 2023 Oct 16. PMID: 37845017
  • Slogrove AL, Burmen B, Davies MA, Edmonds A, Abrams EJ, Chadwick EG, Goetghebuer T, Mofenson LM, Paul ME, Thorne C, Williams PL, Vicari M, Powis KM. Standardized Definitions of In Utero Human Immunodeficiency Virus and Antiretroviral Drug Exposure Among Children. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2022 Aug 25;75(2):347-355. PMID: 35181789
  • Lemon TL, Tassiopoulos K, Tsai AC, Cantos K, Escudero D, Quinn MK, Kacanek D, Berman C, Salomon L, Nichols S, Chadwick EG, Seage GR 3rd, Williams PL, Pediatric HIV/AIDS Cohort Study (PHACS). Health Insurance Coverage, Clinical Outcomes, and Health-Related Quality of Life Among Youth Born to Women Living With HIV. Journal of acquired immune deficiency syndromes (1999). 2023 Jan 1;92(1):6-16. PMID: 36150048
  • Yu W, Jacobson DL, Williams PL, Patel K, Geffner ME, Van Dyke RB, Kacanek D, DiMeglio LA, Jao J, Pediatric HIV/AIDS Cohort Study (PHACS). Growth patterns of uninfected children born to women living with perinatally versus nonperinatally acquired HIV. AIDS (London, England). 2022 Mar 15;36(4):593-603. PMID: 34860195
  • Barnard-Mayers R, Kouser H, Cohen JA, Tassiopoulos K, Caniglia EC, Moscicki AB, Campos NG, Caunca MR, Seage GRS, Murray EJ. A case study and proposal for publishing directed acyclic graphs: The effectiveness of the quadrivalent human papillomavirus vaccine in perinatally HIV Infected girls. Journal of clinical epidemiology. 2022 Apr;144:127-135. Epub 2022 Jan 5. PMID: 34998951
  • Young MR, Broadwell C, Kacanek D, Chadwick EG, Jao J, Moscicki AB, Powis K, Tassiopoulos K, Yee LM, Haddad LB, Pediatric HIV/AIDS Cohort Study. Sexually Transmitted Infections in Pregnant People With Human Immunodeficiency Virus: Temporal Trends, Demographic Correlates, and Association With Preterm Birth. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2022 Dec 19;75(12):2211-2218. PMID: 35486952
  • Jao J, Kacanek D, Broadwell C, Jacobson DL, Chadwick EG, Williams PL, Powis KM, Haddad LB, Yee L, Pediatric HIV/AIDS Cohort Study. Gestational weight gain in persons with HIV in the United States. AIDS (London, England). 2023 May 1;37(6):883-893. Epub 2022 Dec 2. PMID: 36729961
  • Davtyan M, Kacanek D, Lee J, Berman C, Chadwick EG, Smith R, Salomon L, Frederick T, Pediatric HIV/AIDS Cohort Study. Factors associated with internalized HIV-related stigma among biological mothers living with HIV enrolled in a US cohort study. AIDS care. 2024 Feb;36(2):220-226. Epub 2024 Jan 30. PMID: 37757482
  • Shiau S, Brummel SS, Kennedy EM, Hermetz K, Spector SA, Williams PL, Kacanek D, Smith R, Drury SS, Agwu A, Ellis A, Patel K, Seage GR 3rd, Van Dyke RB, Marsit CJ, Pediatric HIV/AIDS Cohort Study (PHACS). Longitudinal changes in epigenetic age in youth with perinatally acquired HIV and youth who are perinatally HIV-exposed uninfected. AIDS (London, England). 2021 Apr 1;35(5):811-819. PMID: 33587437
  • Gojanovich GS, Jacobson DL, Broadwell C, Karalius B, Kirmse B, Geffner ME, Jao J, Van Dyke RB, McFarland EJ, Silio M, Crain M, Gerschenson M, Pediatric HIV/AIDS Cohort Study. Associations of FGF21 and GDF15 with mitochondrial dysfunction in children living with perinatally-acquired HIV: A cross-sectional evaluation of pediatric AIDS clinical trials group 219/219C. PloS one. 2021 Dec 31;16(12):e0261563. doi: 10.1371/journal.pone.0261563. eCollection 2021. PMID: 34972147
  • Dirajlal-Fargo S, Williams PL, Broadwell C, McFarland EJ, Powis KM, Jacobson DL, Jao J, Pediatric HIV/AIDS Cohort Study (PHACS). Brief Report: Youth Living With Perinatally Acquired HIV Have Lower Physical Activity Levels as They Age Compared With HIV-Exposed Uninfected Youth. Journal of acquired immune deficiency syndromes (1999). 2021 May 1;87(1):700-705. PMID: 33443964
  • Torre P 3rd, Zhang ZJ, Hoffman HJ, Frederick T, Purswani M, Williams PL, Yao TJ, Pediatric HIV/AIDS Cohort Study (PHACS). Auditory Function in the Pediatric HIV/AIDS Cohort Study Adolescent Master Protocol Up Young Adults: A Pilot Study. Journal of acquired immune deficiency syndromes (1999). 2023 Apr 1;92(4):340-347. PMID: 36729663
  • Dirajlal-Fargo S, Jacobson DL, Yu W, Mirza A, Geffner ME, Jao J, McComsey GA. Gut Dysfunction Markers Are Associated With Body Composition in Youth Living With Perinatally Acquired Human Immunodeficiency Virus. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2022 Sep 29;75(6):945-952. PMID: 35090002
  • Williams PL, Karalius B, Patel K, Aschengrau A, Chakhtoura N, Enriquez N, Moye J, Garvie PA, Monte D, Seage GR 3rd, Zorrilla C, Mussi-Pinhata MM, HIV ZIP Study. Fetal growth assessed via ultrasound in relation to maternal HIV infection status and antiretroviral regimens. AIDS (London, England). 2024 Mar 15;38(4):567-577. Epub 2023 Nov 21. PMID: 37991521
  • Yee LM, Kacanek D, Brightwell C, Haddad LB, Jao J, Powis KM, Yao TJ, Barr E, Broadwell C, Siminski S, Seage GR 3rd, Chadwick EG, Pediatric HIV/AIDS Cohort Study. Marijuana, Opioid, and Alcohol Use Among Pregnant and Postpartum Individuals Living With HIV in the US. JAMA network open. 2021 Dec 1;4(12):e2137162. PMID: 34860242
  • Caceres GA, Scambray KA, Malee K, Smith R, Williams PL, Wang L, Jenkins LM, Pediatric HIV/AIDS Cohort Study. Relationship between brain structural network integrity and emotional symptoms in youth with perinatally-acquired HIV. Brain, behavior, and immunity. 2024 Feb;116:101-113. Epub 2023 Dec 2. PMID: 38043871