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Studying the evolution of cancer malignancy in space and time provides clues that are crucial for understanding how tumors develop, how they evade the immune system, and how they resist therapy and recur. Since 2018, the Human Tumor Atlas Network (HTAN), a US National Cancer Institute (NCI)-funded Cancer MoonshotSM initiative, has been compiling 3D atlases that integrate cellular, molecular and histological features of diverse tumors across the span of cancer evolution.
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