- Day 1: Thursday, May 25, 2023 - 8:00am EDT to 2:00pm EDT
- Day 2: Friday, May 26, 2023 - 8:00am EDT to 12:30pm EDT
May 25, 8 AM-2 PM EDT; 2 PM - 8 PM CET,
May 26, 8 AM – 12:30 PM EDT: 2 PM – 6:30 PM CET,
Times are EDT/Times are CET
May 25:
8:00-8:15 AM EDT
2:00-2:15 PM CET
Opening remarks and charge for the workshop (Sudhir Srivastava, PH.D., M.P.H., National Cancer Institute)
Session 1
- 8:15-9:45 AM EDT (2:15-3:45 PM CET) - Biology of EVs in Pancreatic Cancer (Chair: David Lyden M.D., Ph.D., Weill Cornell Medical Center)
- 8:15-8:35 AM - David C. Lyden, M.D., Ph.D., Weill Cornell Medical Center (TBD)
- 8:35-8:55 AM - Dr. Edit Buzás, M.D., Ph.D., D.Sc., Semmelweis University, (TBD)
- 8:55-9:15 AM - Catherine Alix-Panabières, PhD, University of Montpellier (CTC and their EVs)
- 9:15-9:25 AM - Jennifer Jones, M.D., Ph.D. Center for Cancer Research National Cancer Institute (EV Terminology)
- 9:25-9:45 AM - Discussion Session 1
- 9:45-9:55 AM - Break
Session 2
- 9:55-11:45 AM EDT (3:55-5:45 PM CET) - Technology and methods for detecting/analyzing EVs (Chair: Rosalie Sears. Oregon Health & Science University)
- 9:55-10:15 AM - Rosalie C. Sears, Ph.D., Oregon Health & Science University (TBD)
- 10:15-10:35 AM - Ralph Weissleder, M.D., Ph.D., Massachusetts General Hospital (Extracellular Vesicle Analysis Allows for Identification of Invasive IPMN)
- 10:35-10:55 AM - Tijana Jovanovic-Talisman, Ph.D., City of Hope (Biophysical characterization of pancreatic cancer enriched EVs using Single Extracellular VEsicle Nanoscopy)
- 10:55-11:15 AM - David Issadore, Ph.D., University of Pennsylvania (Microfluidic diagnostic chip Light-activated Proteins and their role in EV packaging)
- 11:15-11-45 AM - Discussion Session 2
- 11:45 AM-12:15 PM (5:45-6:15 PM CET) - Keynote: Klaus Pantel, MD, PHD, University Medical Center Hamburg, (EVs in Liquid Biopsy)
- 12:15-12:30 - Q&A
- 12:30-12:45 PM - Break
Session 3
- 12:45-2:15 PM EDT (6:45-8:15 PM CET) - Early-Stage Investigators (Chair: Haiying Zhang)
- 12:45-1:00 PM ET - Haiying Zhang, Ph.D., Weill Cornell Medical Center (UC modification for EV isolation from Plasma)
- 1:00-1:15 PM - Stuart Ibsen, Ph.D., Oregon Health & Science University (Use of Dielectrophoresis to Recover Cancer-Derived Extracellular Vesicles from Undiluted Plasma for Pancreatic Cancer Detection)
- 1:15-1:30 PM - Yazhen Zhu, M.D., Ph.D., UCLA (Click Chemistry-Mediated Extracellular Vesicle Quantification Assay for Early Detection of Pancreatic Cancer)
- 1:30-1:45 PM EDT - Jacob Geri, Weill Cornell Medical Center (timsTOF mass spectrometry; interacting proteins on EV surface)
- 1:45-2:15 PM - Discussion Session 3
- 2:15 PM EDT (8:15 PM CET) - Adjourn day 1
Day 2, May 26
Session 3
- 8:00-9:30 AM EDT (2:00-3:30 PM CET) - Consortia and Cohorts (Chair: Michael Goggins, M.B.B.Ch., M.D., The Johns Hopkins)
- 8:00-8:15 AM EDT - Matthias Loehr, Ph.D., Karolinska Institute (PANCAID consortium)
- 8:15-8:30 AM - Diane Simeone, M.D., NYU Langone Health Center (PRECEDE: the Pancreatic Cancer Early Detection Consortium)
- 8:30-8:45 AM - Michael Goggins, M.B.B.Ch., M.D., The Johns Hopkins (Cancer of the Pancreas Screening (CAPS))
- 9:45-9:00 - Ann Oberg, PH.D., MAYO Clinic, Rochester, (Pancreatic Cancer Detection Consortium (PCDC))
- 9:00-9:30 AM - Discussion Session 3
Session 4
- 9:30-11:50 AM EDT (3:30-5:50 PM CET) - Biomarker discovery and validation (Ajay Goel, Ph.D., City of Hope)
- 9:30-10:00 AM ET - Keynote Juan Pablo (JP) Hinestrosa, Ph.D. VP, Research Biological Dynamics Inc. (Early-stage detection of pancreatic ductal adenocarcinoma (PDAC), EVs in MCED)
- 10:00-10:15 - Q&A
- 10:15-10:30 AM - Break
- 10:30- 10:50 AM - Daniel W Hagey, Ph.D., Karolinska Institute, Sweden (Dynamic size and association profiles of tumour-derived DNA during pancreatic cancer progression)
- 10:50-11:10 AM - Ajay Goel, Ph.D., City of Hope (Early Detection of Pancreatic Cancer: Are We Ready for Prime Time?)
- 11:10-11:20 - Ajay Pratap Singh, Ph.D., University of South Alabama (EV-derived mitochondrial biomarkers for early detection of pancreatic cancer)
- 11:20-11:50 - Discussion Session 4
- 11:50 AM-12:30 PM (5:50-6:30 PM CET) - Panel Discussion Meeting Overview
- 12:30 PM EDT (6:30 PM CET) - Adjourn