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Program Official
Principal Investigator
Tareq Al Baghdadi
Awardee Organization

Saint Joseph Mercy Health System
United States

Fiscal Year
2025
Activity Code
UG1
Early Stage Investigator Grants (ESI)
Not Applicable
Project End Date

Michigan Cancer Research Consortium NCORP

The mission of the Michigan Cancer Research Consortium (MCRC) is to improve cancer care in the communities it serves, through access to NCI trials. First funded in 1994, as a single hospital Community Clinical Oncology Program, MCRC is now comprised of 15 hospitals and many investigators from 47 practices in five states. MCRC’s membership is a mix of health systems characterized by one or more features critical to performing cancer clinical trials work: Most MCRC members collaborate with Academic Medical Centers. This means they have capabilities for challenging treatment trials and retain patients with rare disease in the community setting. Several MCRC health systems operate as an Integrated Network of Cancer Programs. The synergies, across these sites, support planning and implementation of Cancer Care Delivery and Cancer Control and Prevention Research and promote optimal clinical trial experience for patients and research staff. Two large MCRC health systems operate on the same instance of EPIC throughout multi-state regions. EMR integration enables both centralized screening approaches, for all trials, and non-treatment trial participant recruitment and management, housed at central locations. Taken together, the mature infrastructure of MCRC and member strengths mean it is ideally suited for meeting important aims of the NCI and NCORP. Our approach to these aims includes: 1) Serve our patients from all representative patient groups and geographical areas, 2) Leverage cancer service line and integrated EMR capabilities to efficiently screen and manage our patients on therapeutic trials, cancer care delivery research, and cancer control and prevention trials, 3) Demonstrate clinical research excellence and acumen that is truly unique for a community setting. MCRC will continue to advance and adapt the necessary strategies to enroll to the most innovative protocols involving early-phase research, precision oncology, radiopharmaceuticals, and novel drug combinations for a wide spectrum of solid and hematological malignancies, 4) Advance the field of oncology through: a) multifaceted collaborations with the NCI, Lead Protocol Organizations, and oncology societies and b) dissemination of research results through top-tier journal publications and community engagement efforts.

Publications

  • Smith MR, Jegede OA, Martin P, Till BG, Parekh SS, Yang DT, Hsi ED, Witzig T, Dave S, Scott D, Hanson C, Kostakoglu Shields L, Abdel-Samad N, Casulo C, Bartlett NL, Caimi PF, Al Baghdadi T, Blum KA, Romer MD, Inwards DJ, Lerner RE, Wagner LI, Little RF, Friedberg JW, Leonard JP, Kahl BS. Randomized study of induction with bendamustine-rituximab ± bortezomib and maintenance with rituximab ± lenalidomide for MCL. Blood. 2024 Sep 5;144(10):1083-1092. PMID: 38820500
  • Stearns V, Jegede OA, Chang VT, Skaar TC, Berenberg JL, Nand R, Shafqat A, Jacobs NL, Luginbuhl W, Gilman P, Benson AB 3rd, Goodman JR, Buchschacher GL Jr, Henry NL, Loprinzi CL, Flynn PJ, Mitchell EP, Fisch MJ, Sparano JA, Wagner LI. A Cohort Study to Evaluate Genetic Predictors of Aromatase Inhibitor Musculoskeletal Symptoms: Results from ECOG-ACRIN E1Z11. Clinical cancer research : an official journal of the American Association for Cancer Research. 2024 Jul 1;30(13):2709-2718. PMID: 38640040
  • Steffen McLouth LE, Zhao F, Owonikoko TK, Feliciano JL, Mohindra NA, Dahlberg SE, Wade JL 3rd, Srkalovic G, Lash BW, Leach JW, Leal TA, Aggarwal C, Cella D, Ramalingam SS, Wagner LI. Patient-reported tolerability of veliparib combined with cisplatin and etoposide for treatment of extensive stage small cell lung cancer: Neurotoxicity and adherence data from the ECOG ACRIN cancer research group E2511 phase II randomized trial. Cancer medicine. 2020 Oct;9(20):7511-7523. Epub 2020 Aug 28. PMID: 32860331
  • Smith KL, Zhao F, Mayer IA, Tevaarwerk AJ, Garcia SF, Arteaga CL, Symmans WF, Park BH, Burnette BL, Makower DF, Block M, Morley KA, Jani CR, Mescher C, Dewani SJ, Brown-Glaberman U, Flaum LE, Mayer EL, Sikov WM, Rodler ET, DeMichele AM, Sparano JA, Wolff AC, Miller KD, Wagner LI. Adjuvant platinum versus capecitabine for residual, invasive, triple-negative breast cancer: Patient-reported outcomes in ECOG-ACRIN EA1131. Cancer. 2024 May 15;130(10):1747-1757. Epub 2024 Jan 18. PMID: 38236702
  • Mayer IA, Zhao F, Arteaga CL, Symmans WF, Park BH, Burnette BL, Tevaarwerk AJ, Garcia SF, Smith KL, Makower DF, Block M, Morley KA, Jani CR, Mescher C, Dewani SJ, Tawfik B, Flaum LE, Mayer EL, Sikov WM, Rodler ET, Wagner LI, DeMichele AM, Sparano JA, Wolff AC, Miller KD. Reply to T. Shimoi et al and Y. Shimanuki et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2021 Nov 1;39(31):3522-3524. Epub 2021 Sep 23. PMID: 34554848