Program Official

Principal Investigator

Timothy J
Wilkin
Awardee Organization

Weill Medical Coll Of Cornell Univ
United States

Fiscal Year
2023
Activity Code
U54
Early Stage Investigator Grants (ESI)
Not Applicable
Project End Date

Partnership for Prevention of HPV-Associated Cancers in People Living with HIV: Brazil, Mexico, and Puerto Rico

OVERALL ABSTRACT The Partnership Center, entitled Multinational Partnership to Prevent HPV-Associated Cancer in People Living with HIV: Brazil, Mexico, Puerto Rico (PHAC-BMPR), will bring together experienced research sites and worldrenowned HPV and HIV researchers to build on established collaborations to conduct clinical trials on prevention of HPV-associated cancers among people living with HIV. This will provide an invaluable opportunity for newer investigators from Latin America/Caribbean (LAC) to participate in and learn from highquality research. PHAC-BMPR will focus on two HPV-associated cancers that result in substantial morbidity and mortality: HPVassociated oropharyngeal cancer (HPV-OPC) and cervical cancer. These scientific goals are aligned with the goals of the US National Institutes of Health for research priorities for people living with HIV/AIDS as well as in country and regional goals to reduce cancer morbidity and mortality. At the end of this project, we hope to make advances that will highly impact prevention of HPV-associated cancers in people living with HIV and contribute to the global goal of cervical cancer elimination and reduction of other HPV-associated cancers such as oropharyngeal cancer (OPC).

Publications

  • Castle PE, Einstein MH, Sahasrabuddhe VV. Cervical cancer prevention and control in women living with human immunodeficiency virus. CA: a cancer journal for clinicians. 2021 Nov;71(6):505-526. Epub 2021 Sep 9. PMID: 34499351

Clinical Trials

Study Name Clinical Trial ID
Nine-valent HPV Vaccine to Prevent Persistent Oral HPV Infection in Men Living With HIV NCT04255849
Optimization of Cervical Cancer Screening Among Women Living With HIV in Latin American Countries NCT06002126