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Principal Investigator
Harvey Ira Pass
Awardee Organization

New York University School Of Medicine
United States

Fiscal Year
2021
Activity Code
U01
Project End Date
NIH RePORTER
For more information, see NIH RePORTER Project 3U01CA214195-05S1

The EDRN Mesothelioma Biomarker Discovery Laboratory

The asbestos-related malignancy, malignant pleural mesothelioma (MPM), is often detected in late stages with little chance for survival. Biomarkers are needed to (1)determine which patients have been asbestos exposed (AE) (2) distinguish AE and non-MPM malignancies from MPM patients and (3) determine which MPM patients are at highest risk for early recurrence or death. The EDRN Mesothelioma Biomarker Discovery Laboratory will refine and validate three novel MPM blood/effusion based markers (FBLN3, SOMAmer 13 classifier, HMGB1 Isoforms) and investigate whether immuneoncologic gene expression differences in the cellular component of the circulating blood microenvironment can stratify AE and MPM from other control cohorts. All of these in Phase I/II discovery studies have yielded AUCs > 0.9. An in-house, novel Luminex based assay (Soma 14 NYU MPM) consisting of 13 slow-off-rate-modified-aptamers (SOMAmers) and a newly constructed FBLN3 SOMAmer will be assembled and technically validated using identical specimens that were used to discover these 14 analytes. Diagnostic and prognostic capabilities in both plasma and pleural effusion will be performed with healthy, non-AE exposed, AE, MPM, and non- MPM cancer cohorts, followed by a blinded validation in specimens provided by the Princess Margaret Cancer Center. The University of Hawaii/Cedar Sinai Medical Center, using 202 NYU pleural effusions, will evaluate a unique, technically validated, electrospray ionization liquid chromatography tandem mass spectrometry assay for HMGB1 and its isoforms to differentiate MPM from non-MPM benign and malignant effusions. The HMGB1 effusion results will be compared to those obtained with the Soma 14 NYU MPM using validation cohorts from an approved EDRN MPM screening program in Santiago, Chile and South Glasgow University Hospital. Finally we will refine and validate our buffy coat/PBMC MPM profile of 5 immunooncology genes which in Phase II studies can separate non AE individuals vs AE individuals vs MPM with AUCs of 1.0. These studies could lead to 3 novel platforms which individually or combined could significantly improve chances for early diagnosis and accurate prognostication of patients with MPM.

Publications

  • Carbone M, Adusumilli PS, Alexander HR Jr, Baas P, Bardelli F, Bononi A, Bueno R, Felley-Bosco E, Galateau-Salle F, Jablons D, Mansfield AS, Minaai M, de Perrot M, Pesavento P, Rusch V, Severson DT, Taioli E, Tsao A, Woodard G, Yang H, Zauderer MG, Pass HI. Mesothelioma: Scientific clues for prevention, diagnosis, and therapy. CA: a cancer journal for clinicians. 2019 Sep;69(5):402-429. Epub 2019 Jul 8. PMID: 31283845
  • Carbone M, Minaai M, Kittaneh M, Krausz T, Miettinen MM, Pan Hammarström Q, Hammarström L, Abolhassani H, Pagano I, Xu R, Novelli F, Gaudino G, Pastorino S, Sarin KY, Ripley RT, Pass HI, Schrump DS, Yang H. Clinical and Pathologic Phenotyping of Mesotheliomas Developing in Carriers of Germline BAP1 Mutations. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2025 Nov;20(11):1683-1698. Epub 2025 Jun 27. PMID: 40582407
  • Carbone M, Arron ST, Beutler B, Bononi A, Cavenee W, Cleaver JE, Croce CM, D'Andrea A, Foulkes WD, Gaudino G, Groden JL, Henske EP, Hickson ID, Hwang PM, Kolodner RD, Mak TW, Malkin D, Monnat RJ Jr, Novelli F, Pass HI, Petrini JH, Schmidt LS, Yang H. Tumour predisposition and cancer syndromes as models to study gene-environment interactions. Nature reviews. Cancer. 2020 Sep;20(9):533-549. Epub 2020 May 29. PMID: 32472073
  • McCambridge AJ, Napolitano A, Mansfield AS, Fennell DA, Sekido Y, Nowak AK, Reungwetwattana T, Mao W, Pass HI, Carbone M, Yang H, Peikert T. Progress in the Management of Malignant Pleural Mesothelioma in 2017. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2018 May;13(5):606-623. Epub 2018 Mar 8. PMID: 29524617
  • Schmauch E, Piening BD, Dowdell AK, Mohebnasab M, Williams SH, Stukalov A, Robinson FL, Bombardi R, Jaffe I, Khalil K, Kim J, Aljabban I, Eitan T, O'Brien DP, Rophina M, Wang C, Bartlett AQ, Zanoni F, Albay J, Andrijevic D, Maden B, Mauduit V, Vikman S, Argibay D, Zayas Z, Wu L, Moi K, Lau B, Zhang W, Gragert L, Weldon E, Gao H, Hamilton L, Kagermazova L, Camellato BR, Gandla D, Bhatt R, Gao S, Al-Ali RA, Habara AH, Chang A, Ferdosi S, Chen HM, Motter JD, Thomas SC, Saxena D, Fairchild RL, Loupy A, Heguy A, Crawford A, Batzoglou S, Snyder MP, Siddiqui A, Holmes MV, Chong AS, Kaikkonen MU, Linna-Kuosmanen S, Ayares D, Lorber M, Nellore A, Skolnik EY, Mattoo A, Tatapudi VS, Taft R, Mangiola M, Guo Q, Herati RS, Stern J, Griesemer A, Kellis M, Boeke JD, Montgomery RA, Keating BJ. Multi-omics analysis of a pig-to-human decedent kidney xenotransplant. Nature. 2026 Feb;650(8100):205-217. Epub 2025 Nov 13. PMID: 41233547
  • Choe JK, Byun AJ, Robinson E, Drake L, Tan KS, McAleer EP, Schaffer WL, Liu JE, Chen LL, Buchholz T, Yohannes-Tomicich J, Yarmohammadi H, Ziv E, Solomon SB, Huang J, Park BJ, Jones DR, Adusumilli PS. Management of Pericardial Effusion in Patients With Solid Tumor: An Algorithmic, Multidisciplinary Approach Results in Reduced Mortality After Paradoxical Hemodynamic Instability. Annals of surgery. 2024 Jan 1;279(1):147-153. Epub 2023 Oct 6. PMID: 37800338
  • Dolgalev I, Zhou H, Murrell N, Le H, Sakellaropoulos T, Coudray N, Zhu K, Vasudevaraja V, Yeaton A, Goparaju C, Li Y, Sulaiman I, Tsay JJ, Meyn P, Mohamed H, Sydney I, Shiomi T, Ramaswami S, Narula N, Kulicke R, Davis FP, Stransky N, Smolen GA, Cheng WY, Cai J, Punekar S, Velcheti V, Sterman DH, Poirier JT, Neel B, Wong KK, Chiriboga L, Heguy A, Papagiannakopoulos T, Nadorp B, Snuderl M, Segal LN, Moreira AL, Pass HI, Tsirigos A. Inflammation in the tumor-adjacent lung as a predictor of clinical outcome in lung adenocarcinoma. Nature communications. 2023 Nov 8;14(1):6764. PMID: 37938580
  • Pine PS, Lund SP, Parsons JR, Vang LK, Mahabal AA, Cinquini L, Kelly SC, Kincaid H, Crichton DJ, Spira A, Liu G, Gower AC, Pass HI, Goparaju C, Dubinett SM, Krysan K, Stass SA, Kukuruga D, Van Keuren-Jensen K, Courtright-Lim A, Thompson KL, Rosenzweig BA, Sorbara L, Srivastava S, Salit ML. Summarizing performance for genome scale measurement of miRNA: reference samples and metrics. BMC genomics. 2018 Mar 6;19(1):180. PMID: 29510677
  • Rubino V, Adusumilli PS, Ganbaatar U. CD38 deletion to preserve CAR T cell metabolism and promote functional persistence. Molecular therapy. Oncology. 2024 Jul 13;32(3):200847. doi: 10.1016/j.omton.2024.200847. eCollection 2024 Sep 19. PMID: 39108500
  • Xiong Y, Taleb M, Misawa K, Hou Z, Banerjee S, Amador-Molina A, Jones DR, Chintala NK, Adusumilli PS. c-Kit signaling potentiates CAR T cell efficacy in solid tumors by CD28- and IL-2-independent co-stimulation. Nature cancer. 2023 Jul;4(7):1001-1015. Epub 2023 Jun 19. PMID: 37336986
  • Perego M, Tyurin VA, Tyurina YY, Yellets J, Nacarelli T, Lin C, Nefedova Y, Kossenkov A, Liu Q, Sreedhar S, Pass H, Roth J, Vogl T, Feldser D, Zhang R, Kagan VE, Gabrilovich DI. Reactivation of dormant tumor cells by modified lipids derived from stress-activated neutrophils. Science translational medicine. 2020 Dec 2;12. (572). PMID: 33268511
  • Xue J, Patergnani S, Giorgi C, Suarez J, Goto K, Bononi A, Tanji M, Novelli F, Pastorino S, Xu R, Caroccia N, Dogan AU, Pass HI, Tognon M, Pinton P, Gaudino G, Mak TW, Carbone M, Yang H. Asbestos induces mesothelial cell transformation via HMGB1-driven autophagy. Proceedings of the National Academy of Sciences of the United States of America. 2020 Oct 13;117(41):25543-25552. Epub 2020 Sep 30. PMID: 32999071
  • Xue J, Suarez JS, Minaai M, Li S, Gaudino G, Pass HI, Carbone M, Yang H. HMGB1 as a therapeutic target in disease. Journal of cellular physiology. 2021 May;236(5):3406-3419. Epub 2020 Oct 26. PMID: 33107103
  • Moazami N, Stern JM, Khalil K, Kim JI, Narula N, Mangiola M, Weldon EP, Kagermazova L, James L, Lawson N, Piper GL, Sommer PM, Reyentovich A, Bamira D, Saraon T, Kadosh BS, DiVita M, Goldberg RI, Hussain ST, Chan J, Ngai J, Jan T, Ali NM, Tatapudi VS, Segev DL, Bisen S, Jaffe IS, Piegari B, Kowalski H, Kokkinaki M, Monahan J, Sorrells L, Burdorf L, Boeke JD, Pass H, Goparaju C, Keating B, Ayares D, Lorber M, Griesemer A, Mehta SA, Smith DE, Montgomery RA. Pig-to-human heart xenotransplantation in two recently deceased human recipients. Nature medicine. 2023 Aug;29(8):1989-1997. Epub 2023 Jul 24. PMID: 37488288
  • Xu Y, Medina CG, Surman DR, Dobrolecki LE, Vilchis M, Ramineni M, Hilsenbeck SG, Li Y, Li N, Wu S, Aggison JC, Chen X, Zhu Y, Shen YH, Ripley RT. Co-Targeting BCL-xL with MCL-1 Induces Lethal Mitochondrial Dysfunction in Diffuse Mesothelioma. Molecular cancer therapeutics. 2025 Oct 1;24(10):1640-1652. PMID: 40804773
  • Boeri M, Milione M, Proto C, Signorelli D, Lo Russo G, Galeone C, Verri C, Mensah M, Centonze G, Martinetti A, Sottotetti E, Pastorino U, Garassino MC, Sozzi G. Circulating miRNAs and PD-L1 Tumor Expression Are Associated with Survival in Advanced NSCLC Patients Treated with Immunotherapy: a Prospective Study. Clinical cancer research : an official journal of the American Association for Cancer Research. 2019 Apr 1;25(7):2166-2173. Epub 2019 Jan 7. PMID: 30617131
  • Suarez JS, Novelli F, Goto K, Ehara M, Steele M, Kim JH, Zolondick AA, Xue J, Xu R, Saito M, Pastorino S, Minaai M, Takanishi Y, Emi M, Pagano I, Wakeham A, Berger T, Pass HI, Gaudino G, Mak TW, Carbone M, Yang H. HMGB1 released by mesothelial cells drives the development of asbestos-induced mesothelioma. Proceedings of the National Academy of Sciences of the United States of America. 2023 Sep 26;120(39):e2307999120. Epub 2023 Sep 20. PMID: 37729199
  • Carbone M, Amos C, Attanoos RL, Boeri M, Bueno R, Bunn PA, Chirieac LR, Cooper B, Fennell D, Galateau-Salle F, Giannakou L, Goparaju CV, Hassan R, Hofman P, Kris MG, Mao W, Minaai M, Mitsudomi T, Molina TJ, Montuenga LM, Nabeshima K, Passaro A, Peters S, Rajan A, Richardson DB, Robbins H, Rolfo C, Rudin CM, Samet JM, Scherpereel A, Schrump DS, Sozzi G, Taioli E, Visonà SD, Yang H, Yoshikawa Y, Zhao A, Pass HI. Advances in the Basic Sciences in Thoracic Oncology in the Last 20 Years and Their Translational Impact. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2026 Jan;21(1):41-76. PMID: 41519536
  • Kwok B, Wu BG, Kocak IF, Sulaiman I, Schluger R, Li Y, Anwer R, Goparaju C, Ryan DJ, Sagatelian M, Dreier MS, Murthy V, Rafeq S, Michaud GC, Sterman DH, Bessich JL, Pass HI, Segal LN, Tsay JJ. Pleural fluid microbiota as a biomarker for malignancy and prognosis. Scientific reports. 2023 Feb 8;13(1):2229. PMID: 36755121
  • Guidry K, Vasudevaraja V, Labbe K, Mohamed H, Serrano J, Guidry BW, DeLorenzo M, Zhang H, Deng J, Sahu S, Almonte C, Moreira AL, Tsirigos A, Papagiannakopoulos T, Pass H, Snuderl M, Wong KK. DNA Methylation Profiling Identifies Subgroups of Lung Adenocarcinoma with Distinct Immune Cell Composition, DNA Methylation Age, and Clinical Outcome. Clinical cancer research : an official journal of the American Association for Cancer Research. 2022 Sep 1;28(17):3824-3835. PMID: 35802677
  • Moreira AL, Ocampo PSS, Xia Y, Zhong H, Russell PA, Minami Y, Cooper WA, Yoshida A, Bubendorf L, Papotti M, Pelosi G, Lopez-Rios F, Kunitoki K, Ferrari-Light D, Sholl LM, Beasley MB, Borczuk A, Botling J, Brambilla E, Chen G, Chou TY, Chung JH, Dacic S, Jain D, Hirsch FR, Hwang D, Lantuejoul S, Lin D, Longshore JW, Motoi N, Noguchi M, Poleri C, Rekhtman N, Tsao MS, Thunnissen E, Travis WD, Yatabe Y, Roden AC, Daigneault JB, Wistuba II, Kerr KM, Pass H, Nicholson AG, Mino-Kenudson M. A Grading System for Invasive Pulmonary Adenocarcinoma: A Proposal From the International Association for the Study of Lung Cancer Pathology Committee. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2020 Oct;15(10):1599-1610. Epub 2020 Jun 17. PMID: 32562873
  • Bononi A, Goto K, Ak G, Yoshikawa Y, Emi M, Pastorino S, Carparelli L, Ferro A, Nasu M, Kim JH, Suarez JS, Xu R, Tanji M, Takinishi Y, Minaai M, Novelli F, Pagano I, Gaudino G, Pass HI, Groden J, Grzymski JJ, Metintas M, Akarsu M, Morrow B, Hassan R, Yang H, Carbone M. Heterozygous germline BLM mutations increase susceptibility to asbestos and mesothelioma. Proceedings of the National Academy of Sciences of the United States of America. 2020 Dec 29;117(52):33466-33473. Epub 2020 Dec 14. PMID: 33318203
  • Pass HI, Alimi M, Carbone M, Yang H, Goparaju CM. Mesothelioma Biomarkers: A Review Highlighting Contributions from the Early Detection Research Network. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2020 Dec;29(12):2524-2540. Epub 2020 Jul 22. PMID: 32699075
  • Carbone M, Yang H, Pass HI, Taioli E. Did the Ban on Asbestos Reduce the Incidence of Mesothelioma? Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2023 Jun;18(6):694-697. PMID: 37210180
  • Carbone M, Pass HI, Ak G, Alexander HR Jr, Baas P, Baumann F, Blakely AM, Bueno R, Bzura A, Cardillo G, Churpek JE, Dianzani I, De Rienzo A, Emi M, Emri S, Felley-Bosco E, Fennell DA, Flores RM, Grosso F, Hayward NK, Hesdorffer M, Hoang CD, Johansson PA, Kindler HL, Kittaneh M, Krausz T, Mansfield A, Metintas M, Minaai M, Mutti L, Nielsen M, O'Byrne K, Opitz I, Pastorino S, Pentimalli F, de Perrot M, Pritchard A, Ripley RT, Robinson B, Rusch V, Taioli E, Takinishi Y, Tanji M, Tsao AS, Tuncer AM, Walpole S, Wolf A, Yang H, Yoshikawa Y, Zolondick A, Schrump DS, Hassan R. Medical and Surgical Care of Patients With Mesothelioma and Their Relatives Carrying Germline BAP1 Mutations. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2022 Jul;17(7):873-889. Epub 2022 Apr 21. PMID: 35462085
  • Carbone M, Amelio I, Affar EB, Brugarolas J, Cannon-Albright LA, Cantley LC, Cavenee WK, Chen Z, Croce CM, Andrea A, Gandara D, Giorgi C, Jia W, Lan Q, Mak TW, Manley JL, Mikoshiba K, Onuchic JN, Pass HI, Pinton P, Prives C, Rothman N, Sebti SM, Turkson J, Wu X, Yang H, Yu H, Melino G. Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine. Cell death and differentiation. 2018 Nov;25(11):1885-1904. Epub 2018 Oct 15. PMID: 30323273
  • Tan KS, Reiner A, Emoto K, Eguchi T, Takahashi Y, Aly RG, Rekhtman N, Adusumilli PS, Travis WD. Novel Insights Into the International Association for the Study of Lung Cancer Grading System for Lung Adenocarcinoma. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2024 Jul;37(7):100520. Epub 2024 May 21. PMID: 38777035
  • Quach HT, Hou Z, Bellis RY, Saini JK, Amador-Molina A, Adusumilli PS, Xiong Y. Next-generation immunotherapy for solid tumors: combination immunotherapy with crosstalk blockade of TGFβ and PD-1/PD-L1. Expert opinion on investigational drugs. 2022 Nov;31(11):1187-1202. Epub 2022 Dec 5. PMID: 36448335
  • Wu X, Hernandez FV, Wang H, Wang R, Shiffka S, Shah N, Carr SR, Hoang CD, Blakely AM, Lebensohn A, Mishra K, Xi S, Zhang MR, Tolunay T, Gara S, Absher A, Francis D, Rowland A, Connolly M, Jacobs S, Orfgen S, Driscoll K, Ghafoor A, Lu X, Malouf GG, Yang H, Carbone M, Hassan R, Jones E, Miettinen M, Schrump DS. Prospective Analysis of Mesotheliomas in Subjects With BAP1 Cancer Syndrome: Clinical Characteristics and Epigenetic Correlates of Disease. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2025 Nov;20(11):1699-1715. Epub 2025 Aug 6. PMID: 40774608
  • Shen Y, Goparaju C, Yang Y, Babu BA, Gai W, Pass H, Jiang G. Recurrence prediction of lung adenocarcinoma using an immune gene expression and clinical data trained and validated support vector machine classifier. Translational lung cancer research. 2023 Oct 31;12(10):2055-2067. Epub 2023 Oct 27. PMID: 38025809
  • Byun AJ, Grosser RA, Choe JK, Rizk NP, Tang LH, Molena D, Tan KS, Restle D, Cheema W, Zhu A, Gerdes H, Markowitz AJ, Bains MS, Rusch VW, Jones DR, Adusumilli PS. A Prospective Clinical Trial to Evaluate Mesothelin as a Biomarker for the Clinical Management of Patients With Esophageal Adenocarcinoma. Annals of surgery. 2023 Nov 1;278(5):e1003-e1010. Epub 2023 Apr 27. PMID: 37185875
  • Cerciello F, Choi M, Sinicropi-Yao SL, Lomeo K, Amann JM, Felley-Bosco E, Stahel RA, Robinson BWS, Creaney J, Pass HI, Vitek O, Carbone DP. Verification of a Blood-Based Targeted Proteomics Signature for Malignant Pleural Mesothelioma. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2020 Oct;29(10):1973-1982. Epub 2020 Jul 30. PMID: 32732250
  • Bononi A, Wang Q, Zolondick AA, Bai F, Steele-Tanji M, Suarez JS, Pastorino S, Sipes A, Signorato V, Ferro A, Novelli F, Kim JH, Minaai M, Takinishi Y, Pellegrini L, Napolitano A, Xu R, Farrar C, Goparaju C, Bassi C, Negrini M, Pagano I, Sakamoto G, Gaudino G, Pass HI, Onuchic JN, Yang H, Carbone M. BAP1 is a novel regulator of HIF-1α. Proceedings of the National Academy of Sciences of the United States of America. 2023 Jan 24;120(4):e2217840120. Epub 2023 Jan 19. PMID: 36656861
  • Hu X, Estecio MR, Chen R, Reuben A, Wang L, Fujimoto J, Carrot-Zhang J, McGranahan N, Ying L, Fukuoka J, Chow CW, Pham HHN, Godoy MCB, Carter BW, Behrens C, Zhang J, Antonoff MB, Sepesi B, Lu Y, Pass HI, Kadara H, Scheet P, Vaporciyan AA, Heymach JV, Wistuba II, Lee JJ, Futreal PA, Su D, Issa JJ, Zhang J. Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas. Nature communications. 2021 Jan 29;12(1):687. PMID: 33514726
  • Novelli F, Yoshikawa Y, Vitto VAM, Modesti L, Minaai M, Pastorino S, Emi M, Kim JH, Kricek F, Bai F, Onuchic JN, Bononi A, Suarez JS, Tanji M, Favaron C, Zolondick AA, Xu R, Takanishi Y, Wang Z, Sakamoto G, Gaudino G, Grzymski J, Grosso F, Schrump DS, Pass HI, Atanesyan L, Smout J, Savola S, Sarin KY, Abolhassani H, Hammarström L, Pan-Hammarström Q, Giorgi C, Pinton P, Yang H, Carbone M. Germline BARD1 variants predispose to mesothelioma by impairing DNA repair and calcium signaling. Proceedings of the National Academy of Sciences of the United States of America. 2024 Jul 16;121(29):e2405231121. Epub 2024 Jul 11. PMID: 38990952
  • Devarakonda S, Li Y, Martins Rodrigues F, Sankararaman S, Kadara H, Goparaju C, Lanc I, Pepin K, Waqar SN, Morgensztern D, Ward J, Masood A, Fulton R, Fulton L, Gillette MA, Satpathy S, Carr SA, Wistuba I, Pass H, Wilson RK, Ding L, Govindan R. Genomic Profiling of Lung Adenocarcinoma in Never-Smokers. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2021 Nov 20;39(33):3747-3758. Epub 2021 Sep 30. PMID: 34591593
  • Karasaki T, Moore DA, Veeriah S, Naceur-Lombardelli C, Toncheva A, Magno N, Ward S, Bakir MA, Watkins TBK, Grigoriadis K, Huebner A, Hill MS, Frankell AM, Abbosh C, Puttick C, Zhai H, Gimeno-Valiente F, Saghafinia S, Kanu N, Dietzen M, Pich O, Lim EL, Martínez-Ruiz C, Black JRM, Biswas D, Campbell BB, Lee C, Colliver E, Enfield KSS, Hessey S, Hiley CT, Zaccaria S, Litchfield K, Birkbak NJ, Cadieux EL, Demeulemeester J, Van Loo P, Adusumilli PS, Tan KS, Cheema W, Sanchez-Vega F, Jones DR, Rekhtman N, Travis WD, Hackshaw A, Marafioti T, Salgado R, Le Quesne J, Nicholson AG, TRACERx Consortium, McGranahan N, Swanton C, Jamal-Hanjani M, Van Loo P, Le Quesne J, Lester JF, Bajaj A, Nakas A, Sodha-Ramdeen A, Ang K, Tufail M, Chowdhry MF, Scotland M, Boyles R, Rathinam S, Wilson C, Marrone D, Dulloo S, Fennell DA, Matharu G, Shaw JA, Riley J, Primrose L, Boleti E, Cheyne H, Khalil M, Richardson S, Cruickshank T, Price G, Kerr KM, Benafif S, Gilbert K, Naidu B, Patel AJ, Osman A, Lacson C, Langman G, Shackleford H, Djearaman M, Kadiri S, Middleton G, Leek A, Hodgkinson JD, Totten N, Montero A, Smith E, Fontaine E, Granato F, Doran H, Novasio J, Rammohan K, Joseph L, Bishop P, Shah R, Moss S, Joshi V, Crosbie P, Gomes F, Brown K, Carter M, Chaturvedi A, Priest L, Oliveira P, Lindsay CR, Blackhall FH, Krebs MG, Summers Y, Clipson A, Tugwood J, Kerr A, Rothwell DG, Kilgour E, Dive C, Aerts HJWL, Schwarz RF, Kaufmann TL, Wilson GA, Rosenthal R, Szallasi Z, Kisistok J, Sokac M, Diossy M, Bunkum A, Stewart A, Magness A, Rowan A, Karamani A, Chain B, Castignani C, Bailey C, Weeden CE, Richard C, Pearce DR, Karagianni D, Levi D, Hoxha E, Nye E, Grönroos E, Gálvez-Cancino F, Athanasopoulou F, Kassiotis G, Stavrou G, Mastrokalos G, Lowe HL, Matos IG, Goldman J, Reading JL, Herrero J, Rane JK, Nicod J, Lam JM, Hartley JA, Peggs KS, Selvaraju K, Thol K, Ng KW, Chen K, Dijkstra K, Thakkar K, Ensell L, Shah M, Duran MV, Litovchenko M, Sunderland MW, Leung M, Escudero M, Angelova M, Tanić M, Sivakumar M, Chervova O, Lucas O, Al-Sawaf O, Prymas P, Hobson P, Pawlik P, Stone RK, Bentham R, Hynds RE, Vendramin R, López S, Gamble S, Ung SKA, Quezada SA, Vanloo S, Boeing S, Beck S, Bola SK, Denner T, Mourikis TP, Spanswick V, Barbè V, Lu WT, Hill W, Liu WK, Wu Y, Naito Y, Ramsden Z, Veiga C, Royle G, Collins-Fekete CA, Fraioli F, Ashford P, Clark T, Forster MD, Lee SM, Borg E, Falzon M, Papadatos-Pastos D, Wilson J, Ahmad T, Procter AJ, Ahmed A, Taylor MN, Nair A, Lawrence D, Patrini D, Navani N, Thakrar RM, Janes SM, Hoogenboom EM, Monk F, Holding JW, Choudhary J, Bhakhri K, Scarci M, Hayward M, Panagiotopoulos N, Gorman P, Khiroya R, Stephens RC, Wong YNS, Bandula S, Sharp A, Smith S, Gower N, Dhanda HK, Chan K, Pilotti C, Leslie R, Grapa A, Zhang H, AbdulJabbar K, Pan X, Yuan Y, Chuter D, MacKenzie M, Chee S, Alzetani A, Cave J, Scarlett L, Richards J, Ingram P, Austin S, Lim E, De Sousa P, Jordan S, Rice A, Raubenheimer H, Bhayani H, Ambrose L, Devaraj A, Chavan H, Begum S, Buderi SI, Kaniu D, Malima M, Booth S, Fernandes N, Shah P, Proli C, Hewish M, Danson S, Shackcloth MJ, Robinson L, Russell P, Blyth KG, Dick C, Kirk A, Asif M, Bilancia R, Kostoulas N, Thomas M. Evolutionary characterization of lung adenocarcinoma morphology in TRACERx. Nature medicine. 2023 Apr;29(4):833-845. Epub 2023 Apr 12. PMID: 37045996
  • Carbone M, Harbour JW, Brugarolas J, Bononi A, Pagano I, Dey A, Krausz T, Pass HI, Yang H, Gaudino G. Biological Mechanisms and Clinical Significance of BAP1 Mutations in Human Cancer. Cancer discovery. 2020 Aug;10(8):1103-1120. Epub 2020 Jul 20. PMID: 32690542
  • Novelli F, Bononi A, Wang Q, Bai F, Patergnani S, Kricek F, Haglund E, Suarez JS, Tanji M, Xu R, Takanishi Y, Minaai M, Pastorino S, Morris P, Sakamoto G, Pass HI, Barbour H, Gaudino G, Giorgi C, Pinton P, Onuchic JN, Yang H, Carbone M. BAP1 forms a trimer with HMGB1 and HDAC1 that modulates gene × environment interaction with asbestos. Proceedings of the National Academy of Sciences of the United States of America. 2021 Nov 30;118. (48). PMID: 34815344
  • Misawa K, Bhat H, Adusumilli PS, Hou Z. Combinational CAR T-cell therapy for solid tumors: Requisites, rationales, and trials. Pharmacology & therapeutics. 2025 Feb;266:108763. Epub 2024 Nov 29. PMID: 39617146
  • Zolondick AA, Gaudino G, Xue J, Pass HI, Carbone M, Yang H. Asbestos-induced chronic inflammation in malignant pleural mesothelioma and related therapeutic approaches-a narrative review. Precision cancer medicine. 2021 Sep;4. Epub 2021 Sep 30. PMID: 35098108