Principal Investigator

Yujin
Hoshida
Awardee Organization

Ut Southwestern Medical Center
United States

Fiscal Year
2023
Activity Code
R01
Early Stage Investigator Grants (ESI)
Not Applicable
Project End Date

Reverse-engineering precision liver cancer chemoprevention

Identification of clinically relevant cancer chemoprevention targets has been challenging. Our multidisciplinary team (Precision Liver Cancer Prevention Consortium) will employ an innovative reverse-engineering approach, starting from transcriptome analysis of archived clinical specimens with long-term clinical follow-up, then moving to multifold experimental verification of only clinically well-validated targets, to elucidate chemoprevention targets with the highest likelihood of successful clinical application. With this approach, we could successfully identify liver cancer risk signatures and chemoprevention dugs, leading to a clinical trial (NCT02273362). To achieve our long-term goal of establishing clinically applicable chemoprevention strategies, here we aim to elucidate molecular dysregulation underlying carcinogenic milieu in livers affected with nonalcoholic steatohepatitis (NASH), the fastest rising liver cancer etiology, as clues to refined chemoprevention targets, drugs, and biomarker assays, which are expected to enable personalized patient management and more cost-effective liver cancer chemoprevention clinical trials, and lead to revolutionary improvement of patient prognosis and establishment of a new paradigm, reverse-engineering precision cancer prevention. Aim 1. Computationally-targeted screening of liver cancer chemoprevention agents. Candidate liver cancer chemopreventive compounds will be computationally prioritized, and screened together with LPA pathway inhibitor library in liver cancer risk signature-inducible cell system for the gene signature reversal. For selected compounds in the screen, mechanisms of action will be interrogated by gain- or loss-of-function assessment in the cell system. Aim 2. Functional validation of candidate liver cancer chemoprevention agents. In vivo liver cancer chemopreventive effect of the candidate agents will be validated in a diet-induced fibrotic/carcinogenic rat model mimicking global human cirrhosis transcriptome. Human relevance of the agents will be evaluated in organotypic ex vivo culture of clinical fibrotic liver tissues (n=30). To determine target cell type(s) and mechanisms of action for the agents, major hepatic cell types will be isolated from the rats, and transcriptome profiling will be performed to assess liver cancer risk signature member genes, the inferred target genes for the compounds, and related molecular pathways. Human fibrotic/cirrhotic NASH livers will be similarly profiled for cell type-specific transcriptomic dysregulation to verify that the modulated genes are relevant in human. Aim 3. Development of tissue- and serum-based liver cancer risk biomarker assays. Liver tissue-based cancer risk signatures will be implemented in clinically applicable tissue- (NanoString) and serum- (Luminex) based assays, and evaluated for technical validity and capability to predict future cancer risk in a cohort of 200 NASH patients with paired serum and liver tissue specimens as well as completed long-term clinical observation for cancer development.

Publications

  • Désert R, Giannone F, Schuster C, Baumert TF. Tumor microenvironment-derived serum markers as a new frontier of diagnostic and prognostic assessment in biliary tract cancers. International journal of cancer. 2023 Mar 1;152(5):804-806. Epub 2022 Dec 1. PMID: 36455586
  • Rezaee-Zavareh MS, Koltsova EK, Hoshida Y, Yang JD. Primary liver cancer spectrum: current knowledge and the next steps. Hepatobiliary surgery and nutrition. 2024 Feb 1;13(1):157-160. Epub 2024 Jan 15. PMID: 38322221
  • Rasha F, Paul S, Simon TG, Hoshida Y. Hepatocellular Carcinoma Chemoprevention with Generic Agents. Seminars in liver disease. 2022 Nov;42(4):501-513. Epub 2022 Sep 14. PMID: 36104114
  • Sojoodi M, Erstad DJ, Barrett SC, Salloum S, Zhu S, Qian T, Colon S, Gale EM, Jordan VC, Wang Y, Li S, Ataeinia B, Jalilifiroozinezhad S, Lanuti M, Zukerberg L, Caravan P, Hoshida Y, Chung RT, Bhave G, Lauer GM, Fuchs BC, Tanabe KK. Peroxidasin Deficiency Re-programs Macrophages Toward Pro-fibrolysis Function and Promotes Collagen Resolution in Liver. Cellular and molecular gastroenterology and hepatology. 2022;13(5):1483-1509. Epub 2022 Jan 28. PMID: 35093588
  • Crouchet E, Schuster C, Baumert TF. Liver cell circuits and therapeutic discovery for advanced liver disease and cancer. Comptes rendus biologies. 2021 Nov 15;344(3):233-248. PMID: 35786628
  • Kawamura S, Matsushita Y, Kurosaki S, Tange M, Fujiwara N, Hayata Y, Hayakawa Y, Suzuki N, Hata M, Tsuboi M, Kishikawa T, Kinoshita H, Nakatsuka T, Sato M, Kudo Y, Hoshida Y, Umemura A, Eguchi A, Ikenoue T, Hirata Y, Uesugi M, Tateishi R, Tateishi K, Fujishiro M, Koike K, Nakagawa H. Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis. The Journal of clinical investigation. 2022 Jun 1;132. (11). PMID: 35380992
  • Kim V, Wal TV, Nishi MY, Montenegro LR, Carrilho FJ, Hoshida Y, Ono SK. Brazilian cohort and genes encoding for drug-metabolizing enzymes and drug transporters. Pharmacogenomics. 2020 Jun;21(9):575-586. Epub 2020 Jun 3. PMID: 32486903
  • Ha K, Fujita M, Karlić R, Yang S, Xue R, Zhang C, Bai F, Zhang N, Hoshida Y, Polak P, Nakagawa H, Kim HG, Lee H. Somatic mutation landscape reveals differential variability of cell-of-origin for primary liver cancer. Heliyon. 2020 Feb 11;6(2):e03350. doi: 10.1016/j.heliyon.2020.e03350. eCollection 2020 Feb. PMID: 32083210
  • Rocha C, Doyle EH, Bowman CA, Fiel MI, Stueck AE, Goossens N, Bichoupan K, Patel N, Crismale JF, Makkar J, Lewis S, Perumalswami PV, Schiano TD, Hoshida Y, Schwartz M, Branch AD. Hepatocellular carcinoma in patients cured of chronic hepatitis C: Minimal steatosis. Cancer medicine. 2023 May;12(9):10175-10186. Epub 2023 Apr 20. PMID: 37078924
  • Rich NE, John BV, Parikh ND, Rowe I, Mehta N, Khatri G, Thomas SM, Anis M, Mendiratta-Lala M, Hernandez C, Odewole M, Sundaram LT, Konjeti VR, Shetty S, Shah T, Zhu H, Yopp AC, Hoshida Y, Yao FY, Marrero JA, Singal AG. Hepatocellular Carcinoma Demonstrates Heterogeneous Growth Patterns in a Multicenter Cohort of Patients With Cirrhosis. Hepatology (Baltimore, Md.). 2020 Nov;72(5):1654-1665. Epub 2020 Oct 25. PMID: 32017165
  • Lupberger J, Baumert TF. Memories of Stress: The Imprinted Cancer Risk After HCV Cure. Cellular and molecular gastroenterology and hepatology. 2023;16(2):323-324. Epub 2023 Jun 2. PMID: 37271182
  • Singal AG, Hoshida Y, Pinato DJ, Marrero J, Nault JC, Paradis V, Tayob N, Sherman M, Lim YS, Feng Z, Lok AS, Rinaudo JA, Srivastava S, Llovet JM, Villanueva A. International Liver Cancer Association (ILCA) White Paper on Biomarker Development for Hepatocellular Carcinoma. Gastroenterology. 2021 Jun;160(7):2572-2584. Epub 2021 Mar 9. PMID: 33705745
  • Wang X, He Q, Zhou C, Xu Y, Liu D, Fujiwara N, Kubota N, Click A, Henderson P, Vancil J, Marquez CA, Gunasekaran G, Schwartz ME, Tabrizian P, Sarpel U, Fiel MI, Diao Y, Sun B, Hoshida Y, Liang S, Zhong Z. Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development. Immunity. 2023 Jan 10;56(1):58-77.e11. Epub 2022 Dec 14. PMID: 36521495
  • Hoshida Y. Current Status of the Use of Statins and Aspirin in the Chemoprevention of Hepatocellular Carcinoma. Gastroenterology & hepatology. 2020 Jun;16(6):319-321. PMID: 34035736
  • Dhanasekaran R, Suzuki H, Lemaitre L, Kubota N, Hoshida Y. Molecular and immune landscape of hepatocellular carcinoma to guide therapeutic decision-making. Hepatology (Baltimore, Md.). 2023 Jun 12. Epub 2023 Jun 12. PMID: 37300379
  • Li S, Ghoshal S, Sojoodi M, Arora G, Masia R, Erstad DJ, Lanuti M, Hoshida Y, Baumert TF, Tanabe KK, Fuchs BC. Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 2019 Jan;23(1):101-111. Epub 2018 Oct 26. PMID: 30367397
  • Jühling F, Hamdane N, Crouchet E, Li S, El Saghire H, Mukherji A, Fujiwara N, Oudot MA, Thumann C, Saviano A, Roca Suarez AA, Goto K, Masia R, Sojoodi M, Arora G, Aikata H, Ono A, Tabrizian P, Schwartz M, Polyak SJ, Davidson I, Schmidl C, Bock C, Schuster C, Chayama K, Pessaux P, Tanabe KK, Hoshida Y, Zeisel MB, Duong FH, Fuchs BC, Baumert TF. Targeting clinical epigenetic reprogramming for chemoprevention of metabolic and viral hepatocellular carcinoma. Gut. 2021 Jan;70(1):157-169. Epub 2020 Mar 26. PMID: 32217639
  • Kubota N, Fujiwara N, Hoshida Y. Clinical and Molecular Prediction of Hepatocellular Carcinoma Risk. Journal of clinical medicine. 2020 Nov 26;9. (12). PMID: 33256232
  • Arvind A, Joshi S, Zaki T, Burkholder D, Parikh ND, Singal AG, North American Liver Cancer (NALC) Consortium, Yekkaluri S, Yokoo T, Fetzer D, Browning T, Rich NE, Khatri G, Zhu H, Hoshida Y, Marrero JA, Yopp AC, Gopal P, Manwaring C. Risk of Hepatocellular Carcinoma in Patients With Indeterminate (LI-RADS 3) Liver Observations. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2023 Apr;21(4):1091-1093.e3. Epub 2021 Dec 10. PMID: 34902571
  • Kim MH, Kim MY, Salloum S, Qian T, Wong LP, Xu M, Lee Y, Shroff SG, Sadreyev RI, Corey KE, Baumert TF, Hoshida Y, Chung RT. Atorvastatin favorably modulates a clinical hepatocellular carcinoma risk gene signature. Hepatology communications. 2022 Sep;6(9):2581-2593. Epub 2022 Jun 16. PMID: 35712812
  • Baumert TF. The Nobel Prize in Medicine 2020 for the Discovery of Hepatitis C Virus: Transforming Hepatology. Journal of hepatology. 2020 Dec;73(6):1303-1305. PMID: 33213742
  • Hectors SJ, Lewis S, Besa C, King MJ, Said D, Putra J, Ward S, Higashi T, Thung S, Yao S, Laface I, Schwartz M, Gnjatic S, Merad M, Hoshida Y, Taouli B. MRI radiomics features predict immuno-oncological characteristics of hepatocellular carcinoma. European radiology. 2020 Jul;30(7):3759-3769. Epub 2020 Feb 21. PMID: 32086577
  • Fujiwara N, Kubota N, Crouchet E, Koneru B, Marquez CA, Jajoriya AK, Panda G, Qian T, Zhu S, Goossens N, Wang X, Liang S, Zhong Z, Lewis S, Taouli B, Schwartz ME, Fiel MI, Singal AG, Marrero JA, Fobar AJ, Parikh ND, Raman I, Li QZ, Taguri M, Ono A, Aikata H, Nakahara T, Nakagawa H, Matsushita Y, Tateishi R, Koike K, Kobayashi M, Higashi T, Nakagawa S, Yamashita YI, Beppu T, Baba H, Kumada H, Chayama K, Baumert TF, Hoshida Y. Molecular signatures of long-term hepatocellular carcinoma risk in nonalcoholic fatty liver disease. Science translational medicine. 2022 Jun 22;14(650):eabo4474. Epub 2022 Jun 22. PMID: 35731891
  • Dana J, Venkatasamy A, Saviano A, Lupberger J, Hoshida Y, Vilgrain V, Nahon P, Reinhold C, Gallix B, Baumert TF. Conventional and artificial intelligence-based imaging for biomarker discovery in chronic liver disease. Hepatology international. 2022 Jun;16(3):509-522. Epub 2022 Feb 9. PMID: 35138551
  • Qian T, Fujiwara N, Koneru B, Ono A, Kubota N, Jajoriya AK, Tung MG, Crouchet E, Song WM, Marquez CA, Panda G, Hoshida A, Raman I, Li QZ, Lewis C, Yopp A, Rich NE, Singal AG, Nakagawa S, Goossens N, Higashi T, Koh AP, Bian CB, Hoshida H, Tabrizian P, Gunasekaran G, Florman S, Schwarz ME, Hiotis SP, Nakahara T, Aikata H, Murakami E, Beppu T, Baba H, Rew Warren, Bhatia S, Kobayashi M, Kumada H, Fobar AJ, Parikh ND, Marrero JA, Rwema SH, Nair V, Patel M, Kim-Schulze S, Corey K, O'Leary JG, Klintmalm GB, Thomas DL, Dibas M, Rodriguez G, Zhang B, Friedman SL, Baumert TF, Fuchs BC, Chayama K, Zhu S, Chung RT, Hoshida Y. Molecular Signature Predictive of Long-Term Liver Fibrosis Progression to Inform Antifibrotic Drug Development. Gastroenterology. 2022 Apr;162(4):1210-1225. Epub 2021 Dec 22. PMID: 34951993
  • Saviano A, Baumert TF. Unraveling the role of liver sinusoidal endothelial cells in COVID-19 liver injury. Journal of hepatology. 2021 Sep;75(3):503-505. Epub 2021 Jul 15. PMID: 34274367
  • Fujiwara N, Singal AG, Hoshida Y. Dose and Duration of Aspirin Use to Reduce Incident Hepatocellular Carcinoma. Hepatology (Baltimore, Md.). 2019 Dec;70(6):2216-2217. Epub 2019 Aug 7. PMID: 31206214
  • Singal AG, Zhang E, Narasimman M, Rich NE, Waljee AK, Hoshida Y, Yang JD, Reig M, Cabibbo G, Nahon P, Parikh ND, Marrero JA. HCC surveillance improves early detection, curative treatment receipt, and survival in patients with cirrhosis: A meta-analysis. Journal of hepatology. 2022 Jul;77(1):128-139. Epub 2022 Feb 6. PMID: 35139400
  • DelaCourt A, Black A, Angel P, Drake R, Hoshida Y, Singal A, Lewin D, Taouli B, Lewis S, Schwarz M, Fiel MI, Mehta AS. N-Glycosylation Patterns Correlate with Hepatocellular Carcinoma Genetic Subtypes. Molecular cancer research : MCR. 2021 Nov;19(11):1868-1877. Epub 2021 Aug 11. PMID: 34380744
  • Yarchoan M, Agarwal P, Villanueva A, Rao S, Dawson LA, Llovet JM, Finn RS, Groopman JD, El-Serag HB, Monga SP, Wang XW, Karin M, Schwartz RE, Tanabe KK, Roberts LR, Gunaratne PH, Tsung A, Brown KA, Lawrence TS, Salem R, Singal AG, Kim AK, Rabiee A, Resar L, Hoshida Y, He AR, Ghoshal K, Ryan PB, Jaffee EM, Guha C, Mishra L, Coleman CN, Ahmed MM. Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma. Cancer research. 2019 Sep 1;79(17):4326-4330. PMID: 31481419
  • Eller C, Heydmann L, Colpitts CC, El Saghire H, Piccioni F, Jühling F, Majzoub K, Pons C, Bach C, Lucifora J, Lupberger J, Nassal M, Cowley GS, Fujiwara N, Hsieh SY, Hoshida Y, Felli E, Pessaux P, Sureau C, Schuster C, Root DE, Verrier ER, Baumert TF. A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor. Nature communications. 2020 Jun 1;11(1):2707. PMID: 32483149
  • Lee YT, Fujiwara N, Yang JD, Hoshida Y. Risk stratification and early detection biomarkers for precision HCC screening. Hepatology (Baltimore, Md.). 2023 Jul 1;78(1):319-362. Epub 2022 Oct 11. PMID: 36082510
  • Fujiwara N, Kobayashi M, Fobar AJ, Hoshida A, Marquez CA, Koneru B, Panda G, Taguri M, Qian T, Raman I, Li QZ, Hoshida H, Sezaki H, Kumada H, Tateishi R, Yokoo T, Yopp AC, Chung RT, Fuchs BC, Baumert TF, Marrero JA, Parikh ND, Zhu S, Singal AG, Hoshida Y. A blood-based prognostic liver secretome signature and long-term hepatocellular carcinoma risk in advanced liver fibrosis. Med (New York, N.Y.). 2021 Jul 9;2(7):836-850.e10. Epub 2021 Apr 21. PMID: 34318286
  • Zhu S, Kubota N, Hoshida Y. Transcriptome-Guided Design of Physiological Multilineage Liver Organoids. Trends in genetics : TIG. 2021 May;37(5):403-404. Epub 2021 Feb 1. PMID: 33541711
  • Mender I, Siteni S, Barron S, Flusche AM, Kubota N, Yu C, Cornelius C, Tedone E, Maziveyi M, Grichuk A, Venkateswaran N, Conacci-Sorrell M, Hoshida Y, Kang R, Tang D, Gryaznov S, Shay JW. Activating an Adaptive Immune Response with a Telomerase-Mediated Telomere Targeting Therapeutic in Hepatocellular Carcinoma. Molecular cancer therapeutics. 2023 Jun 1;22(6):737-750. PMID: 37070671
  • Sojoodi M, Wei L, Erstad DJ, Yamada S, Fujii T, Hirschfield H, Kim RS, Lauwers GY, Lanuti M, Hoshida Y, Tanabe KK, Fuchs BC. Epigallocatechin Gallate Induces Hepatic Stellate Cell Senescence and Attenuates Development of Hepatocellular Carcinoma. Cancer prevention research (Philadelphia, Pa.). 2020 Jun;13(6):497-508. Epub 2020 Apr 6. PMID: 32253266
  • Saito Y, Yin D, Kubota N, Wang X, Filliol A, Remotti H, Nair A, Fazlollahi L, Hoshida Y, Tabas I, Wangensteen KJ, Schwabe RF. A Therapeutically Targetable TAZ-TEAD2 Pathway Drives the Growth of Hepatocellular Carcinoma via ANLN and KIF23. Gastroenterology. 2023 Jun;164(7):1279-1292. Epub 2023 Mar 7. PMID: 36894036
  • Liu PH, Hsu CY, Su CW, Huang YH, Hou MC, Rich NE, Fujiwara N, Hoshida Y, Singal AG, Huo TI. Thrombocytosis is associated with worse survival in patients with hepatocellular carcinoma. Liver international : official journal of the International Association for the Study of the Liver. 2020 Oct;40(10):2522-2534. Epub 2020 Jun 28. PMID: 32511831
  • Fujiwara N, Kubota N, Zhu S, Nakagawa S, Baba H, Hoshida Y. Disseminative Recurrence Signature for Hepatocellular Carcinoma From Nonalcoholic Fatty Liver Disease. Gastro hep advances. 2023;2(5):681-683. Epub 2023 Mar 20. PMID: 37621719
  • Wen Z, Lin YH, Wang S, Fujiwara N, Rong R, Jin KW, Yang DM, Yao B, Yang S, Wang T, Xie Y, Hoshida Y, Zhu H, Xiao G. Deep-Learning-Based Hepatic Ploidy Quantification Using H&E Histopathology Images. Genes. 2023 Apr 16;14. (4). PMID: 37107679
  • Kanzaki H, Katz C, Hoshida Y. Matrisomic characterization of HCC to inform individualized patient management. Hepatology (Baltimore, Md.). 2023 Sep 1;78(3):691-693. Epub 2023 May 11. PMID: 37163234
  • Fujiwara N, Qian T, Koneru B, Hoshida Y. Omics-derived hepatocellular carcinoma risk biomarkers for precision care of chronic liver diseases. Hepatology research : the official journal of the Japan Society of Hepatology. 2020 Jul;50(7):817-830. Epub 2020 May 15. PMID: 32323426
  • Qin J, Higashi T, Nakagawa S, Fujiwara N, Yamashita YI, Beppu T, Baba H, Kobayashi M, Kumada H, Gunasekaran G, Schiano TD, Thung SN, Fiel MI, Hoshida Y, Ward SC. Steatohepatitic Variant of Hepatocellular Carcinoma Is Associated With Both Alcoholic Steatohepatitis and Nonalcoholic Steatohepatitis: A Study of 2 Cohorts With Molecular Insights. The American journal of surgical pathology. 2020 Oct;44(10):1406-1412. PMID: 32618599
  • Lupberger J, Baumert TF. Virus-Induced Risk of Hepatocellular Carcinoma: Recent Progress and Future Challenges. Journal of clinical medicine. 2021 Dec 31;11. (1). PMID: 35011949
  • Desert R, Ge X, Song Z, Han H, Lantvit D, Chen W, Das S, Athavale D, Abraham-Enachescu I, Blajszczak C, Chen Y, Musso O, Guzman G, Hoshida Y, Nieto N. Role of Hepatocyte-Derived Osteopontin in Liver Carcinogenesis. Hepatology communications. 2022 Apr;6(4):692-709. Epub 2021 Nov 3. PMID: 34730871
  • Crouchet E, Li S, Sojoodi M, Bandiera S, Fujiwara N, El Saghire H, Zhu S, Qian T, Rasha FA, Del Zompo F, Barrett SC, Schaeffer E, Oudot MA, Ponsolles C, Durand SC, Ghoshal S, Arora G, Giannone F, Chung RT, Slovic N, Van Renne N, Felli E, Pessaux P, Lupberger J, Pochet N, Schuster C, Tanabe KK, Hoshida Y, Fuchs BC, Baumert TF. Hepatocellular carcinoma chemoprevention by targeting the angiotensin-converting enzyme and EGFR transactivation. JCI insight. 2022 Jul 8;7. (13). PMID: 35801591
  • Wang Z, Zhu S, Jia Y, Wang Y, Kubota N, Fujiwara N, Gordillo R, Lewis C, Zhu M, Sharma T, Li L, Zeng Q, Lin YH, Hsieh MH, Gopal P, Wang T, Hoare M, Campbell P, Hoshida Y, Zhu H. Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease. Cell. 2023 Apr 27;186(9):1968-1984.e20. Epub 2023 Apr 10. PMID: 37040760
  • Fujiwara N, Hoshida Y. Viral Exposure Signature Associated with Liver Cancer Risk. Trends in molecular medicine. 2020 Aug;26(8):711-713. Epub 2020 Jul 10. PMID: 32654969
  • Verrier ER, Ligat G, Heydmann L, Doernbrack K, Miller J, Maglott-Roth A, Jühling F, El Saghire H, Heuschkel MJ, Fujiwara N, Hsieh SY, Hoshida Y, Root DE, Felli E, Pessaux P, Mukherji A, Mailly L, Schuster C, Brino L, Nassal M, Baumert TF. Cell-based cccDNA reporter assay combined with functional genomics identifies YBX1 as HBV cccDNA host factor and antiviral candidate target. Gut. 2022 Dec 9;72(9):1745-57. Epub 2022 Dec 9. PMID: 36591611
  • Crouchet E, Bandiera S, Fujiwara N, Li S, El Saghire H, Fernández-Vaquero M, Riedl T, Sun X, Hirschfield H, Jühling F, Zhu S, Roehlen N, Ponsolles C, Heydmann L, Saviano A, Qian T, Venkatesh A, Lupberger J, Verrier ER, Sojoodi M, Oudot MA, Duong FHT, Masia R, Wei L, Thumann C, Durand SC, González-Motos V, Heide D, Hetzer J, Nakagawa S, Ono A, Song WM, Higashi T, Sanchez R, Kim RS, Bian CB, Kiani K, Croonenborghs T, Subramanian A, Chung RT, Straub BK, Schuppan D, Ankavay M, Cocquerel L, Schaeffer E, Goossens N, Koh AP, Mahajan M, Nair VD, Gunasekaran G, Schwartz ME, Bardeesy N, Shalek AK, Rozenblatt-Rosen O, Regev A, Felli E, Pessaux P, Tanabe KK, Heikenwälder M, Schuster C, Pochet N, Zeisel MB, Fuchs BC, Hoshida Y, Baumert TF. A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery. Nature communications. 2021 Sep 17;12(1):5525. PMID: 34535664
  • Lin N, Lin Y, Xu J, Liu D, Li D, Meng H, Gallant MA, Kubota N, Roy D, Li JS, Gorospe EC, Sherman M, Gish RG, Abou-Alfa GK, Nguyen MH, Taggart DJ, Van Etten RA, Hoshida Y, Li W. A multi-analyte cell-free DNA-based blood test for early detection of hepatocellular carcinoma. Hepatology communications. 2022 Jul;6(7):1753-1763. Epub 2022 Mar 3. PMID: 35244350
  • Fujiwara N, Trépo E, Raman I, Li QZ, Degré D, Gustot T, Moreno C, Hoshida Y. Plasma-Signature-Model for End-Stage Liver Disease Score to Predict Survival in Severe Alcoholic Hepatitis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2022 Mar;20(3):651-657. Epub 2021 Mar 2. PMID: 33667676
  • Santasusagna S, Zhu S, Jawalagatti V, Carceles-Cordon M, Ertel A, Garcia-Longarte S, Song WM, Fujiwara N, Li P, Mendizabal I, Petrylak DP, Kelly WK, Reddy EP, Wang L, Schiewer MJ, Lujambio A, Karnes J, Knudsen KE, Cordon-Cardo C, Dong H, Huang H, Carracedo A, Hoshida Y, Rodriguez-Bravo V, Domingo-Domenech J. Master Transcription Factor Reprogramming Unleashes Selective Translation Promoting Castration Resistance and Immune Evasion in Lethal Prostate Cancer. Cancer discovery. 2023 Dec 12;13(12):2584-2609. PMID: 37676710
  • Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, Álvarez ÉMC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Antón Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araújo WL, Araya J, Arden C, Arévalo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnauné-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R, Avagliano L, Ávalos Y, Aveic S, Aveleira CA, Avin-Wittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer JM, Backues SK, Bae DH, Bae ON, Bae SH, Baehrecke EH, Baek A, Baek SH, Baek SH, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari CT, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Banerjee S, Bánréti Á, Bao Y, Baptista MS, Baracca A, Barbati C, Bargiela A, Barilà D, Barlow PG, Barmada SJ, Barreiro E, Barreto GE, Bartek J, Bartel B, Bartolome A, Barve GR, Basagoudanavar SH, Bassham DC, Bast RC Jr, Basu A, Batoko H, Batten I, Baulieu EE, Baumgarner BL, Bayry J, Beale R, Beau I, Beaumatin F, Bechara LRG, Beck GR Jr, Beers MF, Begun J, Behrends C, Behrens GMN, Bei R, 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