Sponsor
Fred Hutchinson Cancer Center
Status
Not yet recruiting
NCT ID
NCT07645378
Cervical cancer disproportionately affects women in low- and middle-income countries (LMICs), particularly women living with HIV (WLWH) who have a 6-fold increased risk of cervical cancer compared to women in the general population. Thermal ablation (TA) is recommended by the World Health Organization (WHO) to treat cervical precancerous lesions, although its efficacy can be suboptimal in WLWH. The proposed study will evaluate the feasibility, acceptability, and safety of a two-probe TA technique (endocervical and ectocervical probes) and whether this approach improves treatment outcomes among WLWH compared to one (ectocervical) probe. This innovation has the potential to significantly enhance cervical cancer prevention efforts in high-burden settings. It will also contribute towards achieving the 90-70-90 goals of the WHO strategy for accelerated elimination of cervical cancer as a public health problem by 2030.
Intervention
Thermal ablation (TA) with 1 probe, Thermal ablation (TA) with 2 probes
Condition
HIV (Human Immunodeficiency Virus), HPV, Cervical Precancer, Cervical Neoplasia
Investigators
Rachel L Winer, PhD, MPH, Margaret M Madeleine, PhD, MPH, Leeya Pinder, MD, MPH, Nivashnee Naicker, MBChB, MAS, MPH
CT Research Area
Symptom Science