Major Program
US-Latin American-Caribbean U54
Research Group
Breast and Gynecologic Cancer
Sponsor
University of California, San Francisco
Status
Recruiting
ClinicalTrials.gov ID
For more information, see ClinicalTrials.gov NCT05074264
This clinical trial aims to find what different tests work best to find high-grade squamous intraepithelial lesions (HSIL) in the cervix or anus in patients living with human immunodeficiency virus (HIV). Patients with HIV are at high risk of becoming infected with human papillomavirus (HPV) in the cervix or anus where it can turn into cancer over several years. HPV causes changes to the cervix and anus, known as HSIL. This means that there is an area of abnormal tissue on the top layers of the cervix or anus. It is considered cervical or anal cancer if the abnormality spreads down into the layers of tissue below the top. If found early, many cases of HSIL can be treated before turning into cancer. Screening for cervical or anal cancer detection or HSIL associated with HPV may result in earlier treatment, if necessary, for patients living with HIV.
Intervention
Biopsy, Biospecimen Collection - Anal, Biospecimen Collection - Cervical, Colposcopy, High Resolution Anoscopy, Imaging Technique
Condition
AIDS-Related Anal Carcinoma, AIDS-Related Cervical Carcinoma, High Grade Anal Intraepithelial Neoplasia, High Grade Cervical Intraepithelial Neoplasia, HIV Infection
Investigators
Joel Palefsky, MD, Jorge Salmerón, MD, MSc, DSc, Andrea Gónzalez, MD, Ana P. Ortiz Martinez, MPH, PhD, Mario Gómez, MD, Alejandro Garcia-Carranca, PhD, Maribel Tirado, MD,