Low-Dose Ibuprofen in Improving Cognitive Impairment in Patients With Cancer

This randomized phase II trial studies how well low-dose ibuprofen in improving cognitive impairment in patients with colorectal cancer that has not spread to other places in the body who are receiving chemotherapy. Anti-inflammatory agents, such as ibuprofen, may slow the decline of cognitive processes and diseases involving the brain.

Intervention

Ibuprofen, Placebo, Questionnaire Administration

Condition

Caregiver, Cognitive Impairment, Stage 0 Colorectal Cancer AJCC v6 and v7, Stage I Colorectal Cancer AJCC v6 and v7, Stage II Colorectal Cancer AJCC v7, Stage IIA Colorectal Cancer AJCC v7, Stage IIB Colorectal Cancer AJCC v7, Stage IIC Colorectal Cancer AJCC v7, Stage III Colorectal Cancer AJCC v7, Stage IIIA Colorectal Cancer AJCC v7, Stage IIIB Colorectal Cancer AJCC v7, Stage IIIC Colorectal Cancer AJCC v7

Investigators

Michelle C Janelsins, Bryan A. Faller, Alison K. Conlin, Kathleen J. Yost, John A. Ellerton, Vicki A. Morrison, Jeffrey K. Giguere, Gregory A. Masters, Christopher H. Chay

See list of participating sites