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Prevention of Bone Loss After Pediatric Hematopoietic Cell Transplantation

Major Program

Supportive Care and Symptom Management

Research Group

Community Oncology and Prevention Trials

Status

Completed

NCT ID

NCT02074631

This is a Phase 2, open-label, randomized, controlled clinical study of pediatric subjects treated with pamidronate with calcium and vitamin D versus calcium and vitamin D alone following hematopoietic cell transplantation (HCT). The purpose of this study is to test the hypothesis that subjects receiving pamidronate with calcium and vitamin D will have higher lumbar spine bone mineral content (LBMC) measured by dual-energy X-ray tomography (DXA) at 1 year post-HCT than subjects receiving calcium and vitamin D alone (Control Group).

Intervention

Pamidronate, Calcium and vitamin D

Condition

Osteopenia, Osteoporosis

Investigators

Kyriakie Sarafoglou, MD

See list of participating sites