Research Group
Gastrointestinal and Other Cancers
Sponsor
Dartmouth-Hitchcock Medical Center
Status
Completed
ClinicalTrials.gov ID
For more information, see ClinicalTrials.gov NCT00153816
Extensive experimental and observational data suggest that intake of calcium and of vitamin D exert protective effects on colorectal neoplasia. Building on their previous work, the investigators will investigate the chemopreventive effect of vitamin D in the large bowel, to study whether calcium with vitamin D is more effective than calcium alone, and to confirm their positive finding regarding calcium. The goal of this study is the development of chemopreventive combinations that will reduce risk of colorectal neoplasia sufficiently to permit the lengthening of surveillance intervals in most patients and to clarify important issues regarding the mechanisms of colorectal carcinogenesis and chemoprevention.
Intervention
Calcium Carbonate, Vitamin D3, placebo
Condition
Colorectal Cancer, Polyps, Adenomas
Investigators
John A. Baron, MD