LungVITamin D and OmegA-3 Trial (lungVITAL)

The VITamin D and OmegA-3 TriaL (VITAL; NCT 01169259) is an ongoing randomized clinical trial in 25,875 U.S. men and women investigating whether taking daily dietary supplements of vitamin D3 (2000 IU) or omega-3 fatty acids (Omacor® fish oil, 1 gram) reduces the risk of developing cancer, heart disease, and stroke in people who do not have a prior history of these illnesses. This ancillary study is being conducted among participants in VITAL and will examine whether vitamin D or fish oil improves respiratory symptoms or reduces the risk of lung infections or reduces the decline of pulmonary function.


fish oil, Fish oil placebo, Vitamin D3, Vitamin D3 placebo


COPD, Asthma, Pulmonary Function, Pneumonia


Diane R Gold, MD, MPH

See list of participating sites