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Supportive Care and Symptom Management

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

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About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience. 

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Funding Opportunities

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Grantee Details

PI Name PI Organization Sort descending Title Grant Number Program Official
Kanarek, Naama

Boston Children'S Hospital
United States

Mechanistic Study of Methotrexate-Induced Oxidative Distress in Neurons and the CSF 5R01CA282477-02 John Clifford, Ph.D.
Matin, Khalid

Virginia Commonwealth University
United States

VCU Massey Cancer Center Minority/Underserved NCI Community Oncology Research Program 3UG1CA189869-11S1 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Rini, Christine

Northwestern University At Chicago
United States

Mosaic: RCT of a Digital Health Intervention Delivering Peer Support Narratives and Psychoeducation to English- and Spanish-Speaking Stem Cell Transplant Recipients 5R01CA292116-02 Brennan Streck, Ph.D., RN, M.P.H.
Blanke, Charles D.

Oregon Health & Science University
United States

SWOG NCORP Research Base 3UG1CA189974-11S1 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Sands, Stephen Alan

Sloan-Kettering Inst Can Research
United States

Prospective international phase-III study to improve neurocognitive outcomes in young children with low-risk medulloblastoma (YCMB-LR) 5R01CA283045-02 Marjorie Perloff, M.D.
Boone, Anna

University Of Missouri-Columbia
United States

Pilot testing of metacognitive strategy training to address cancer-related cognitive impairment in breast cancer 1R21CA286404-01A1 Marjorie Perloff, M.D.
Marker, Ryan J

University Of Colorado Denver
United States

Effects of a telehealth exercise program for rural cancer survivors with cancer-related fatigue including integrated longitudinal assessments of objective physical function and fatty acid oxidation 5R01CA292482-02 Goli Samimi, Ph.D., M.P.H.
Zarrinpar, Amir

University Of California, San Diego
United States

Engineering Native E. coli to Detect, Report, and Treat Colorectal Cancer 5U01CA265719-05 Guillermo Marquez, Ph.D.
Tennis, Meredith A

University Of Colorado Denver
United States

Persistence and regression in lung premalignant lesions 1R01CA289576-01A1 Malgorzata Wojtowicz, M.D.
Hundley, William Gregory

Wake Forest University Health Sciences
United States

Improving Exercise Capacity with a Tailored Physical Activity Intervention in Lymphoma Patients Undergoing Treatment 5R33CA226960-05 Eileen Dimond, R.N., M.S.
Crowder, Sylvia

H. Lee Moffitt Cancer Ctr & Res Inst
United States

The MIND-BC Study: MIND diet for Breast cancer Cognition 1R01CA299480-01 Nancy J. Emenaker, Ph.D., RDN, LD, FAND
Elenitoba-Johnson, Kojo S. J.

Sloan-Kettering Inst Can Research
United States

Genomic biomarkers of splenic lymphoma 5R01CA255655-06 Nicholas Hodges, Ph.D.
Zheng, Qin

Johns Hopkins University
United States

Determining the function of medium to large diameter sensory neurons in paclitaxel-induced pain via large-scale in vivo DRG imaging 1R01CA291906-01A1 Rachel Altshuler, Ph.D.
Geisler, Stefanie

Washington University
United States

Developing mechanism-based strategies to treat chemotherapy-induced peripheral neuropathy 5R37CA267905-04 Asad Umar, D.V.M., Ph.D.
Perez-Lougee, Giselle Katiria

Massachusetts General Hospital
United States

Thriving Beyond Treatment: A Resilience-Based Approach to Improve Long-term Quality of Life in Post-treatment Lymphoma Survivorship 1R37CA303094-01 Marjorie Perloff, M.D.

Clinical Trials

Status
Title Intervention Sponsor Status
A Web-based Program to Help Caregivers of Lung Patients Learn About Available Supportive Care Resources Internet-Based Intervention - CONNECT, Patient Navigation, Support for Caregiver - Generic List, Support for Caregiver - Personalized List Wake Forest University Health Sciences Enrolling by invitation
Additional Support Program Via Text Messaging and Telephone-Based Counseling for Breast Cancer Patients Receiving Hormonal Therapy Best Practice, Educational Intervention, Motivational Interviewing, Quality-of-Life Assessment, Questionnaire Administration, Text Message-based Navigation Intervention Alliance for Clinical Trials in Oncology Active, not recruiting
An Internet-based Program to Help Cancer Survivors Manage Pain Internet-based pain coping skills program Wake Forest University Health Sciences Recruiting
An Observational Research Study to Uncover Subtypes of Cancer Cachexia Biospecimen Collection, Computed Tomography, Electronic Medical Record, Medical Device Usage and Evaluation, Physical Performance Testing, Positron Emission Tomography, Survey Administration University of Rochester NCORP Research Base Recruiting
Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics Non-interventional Study Wake Forest University Health Sciences Recruiting
Assessing Compliance With Mercaptopurine Treatment in Younger Patients With Acute Lymphoblastic Leukemia in First Remission Behavioral Intervention, Compliance Monitoring, Laboratory Biomarker Analysis, Mercaptopurine, Questionnaire Administration, Standard Follow-Up Care Children's Oncology Group Active, not recruiting
Assessment of Cognitive Function in Breast Cancer and Lymphoma Patients Receiving Chemotherapy University of Rochester NCORP Research Base Enrolling by invitation
Axillary Reverse Mapping in Preventing Lymphedema in Patients with Breast Cancer Undergoing Axillary Lymph Node Dissection Axillary Lymph Node Dissection, Isosulfan Blue, Mapping, Quality-of-Life Assessment, Questionnaire Administration Alliance for Clinical Trials in Oncology Active, not recruiting
Bupropion to Reduce Cancer Related Fatigue in Cancer Survivors Biospecimen Collection, Bupropion Hydrochloride Controlled-release, Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration University of Rochester NCORP Research Base Recruiting
Cancer and Blood Pressure Management, CARISMA Study Best Practice, Blood Pressure Measurement, Clinical Management, Quality-of-Life Assessment, Questionnaire Administration ECOG-ACRIN Cancer Research Group Active, not recruiting