The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.
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About Supportive Care and Symptom Management
The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).
Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience.
Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.
Selected Topics
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Research
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Resources
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Building Bridges in Cancer Symptom Science Webinar SeriesThis series is aimed at bringing together interdisciplinary researchers in cancer symptom science to share their expertise and further discussions in the field.
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DCP Early Career Scientist Spotlight Research Seminar SeriesThis seminar series highlights nominated early career scientists who are advancing research within the areas supported by DCP.
Funding Opportunities
| Title Sort ascending | Announcement Number | Activity Code | Clinical Trials Status | Expiration Date | Program Official |
|---|---|---|---|---|---|
| HEAL Initiative: Studies to Enable Analgesic Discovery | RFA-NS-25-023 (R61/R33 - Clinical Trial Not Allowed) | R61, R33 | Clinical Trial Not Allowed | 02/20/2027 | Rachel Altshuler, Ph.D. |
Grantee Details
Clinical Trials
| Title Sort ascending | Intervention | Sponsor | Status |
|---|---|---|---|
| Xylitol Dental Wipes for the Reduction of Bloodstream Infection Risk in Children With Acute Myeloid Leukemia | Best Practice, Biospecimen Collection, Cytarabine, Electronic Health Record Review, Placebo Administration, Xylitol-containing Oral Wipe | Children's Oncology Group | Not yet recruiting |
| Whole-Brain Radiation Therapy With or Without Hippocampal Avoidance in Limited Stage or Extensive Stage Small Cell Lung Cancer | Intensity-Modulated Radiation Therapy, Three-Dimensional Conformal Radiation Therapy | NRG Oncology | Active, not recruiting |
| Wellness App for Sleep Disturbance in Hematological Cancer Patients | Wellness app intervention #1, Wellness app intervention #2 | The University of Texas Health Science Center at San Antonio | Recruiting |
| Web-Based Physical Activity Intervention in Improving Long Term Health in Children and Adolescents With Cancer | Educational Intervention, Internet-Based Intervention, Laboratory Biomarker Analysis, Medical Device Usage and Evaluation, Quality-of-Life Assessment, Questionnaire Administration | Children's Oncology Group | Active, not recruiting |
| Virtual Mental Health Intervention to Address Fear of Progression for Women With High Risk or Stage III-IV Gynecologic or Breast Cancer | Behavioral Intervention, Educational Intervention, Internet-Based Intervention, Interview, Survey Administration, Virtual Technology Intervention | City of Hope Medical Center | Not yet recruiting |
| Use of a Pre-Surgical Toolkit in Improving Surgical Care and Outcomes in Older Participants With Cancer | Best Practice, Informational Intervention, Informational Intervention with Coaching, Questionnaire Administration | Alliance for Clinical Trials in Oncology | Active, not recruiting |
| Understanding Needs of Older Patients Prior to Starting Cancer Treatment | Assessment, Educational Intervention, Electronic Health Record Review, Internet-Based Intervention, Interview, Survey Administration | Wake Forest University Health Sciences | Enrolling by invitation |
| Understanding and Enhancing Health-Related Social Needs (HRSN) Screening Among Community Oncology Practices | Non-Interventional | Wake Forest University Health Sciences | Enrolling by invitation |
| Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer | Best Practice, Biospecimen Collection, Electronic Health Record Review, Survey Administration, Triptorelin Pamoate | Children's Oncology Group | Recruiting |
| Treatment Effects on Development of Chemotherapy-Induced Peripheral Neuropathy in Patients With Cancer | Chemotherapy, Functional Assessment, Questionnaire Administration | SWOG Cancer Research Network | Active, not recruiting |
News and Events
Predicting and Mitigating Nausea and Vomiting
Date Posted: August 22, 2025
Diet and Nutrition for Managing Cancer Symptoms
Date Posted: May 27, 2025
Targeting Aging Biology to Optimize the Long-Term Health of Cancer Survivors
Date Posted: May 15, 2025
Harnessing Studies of Diet and the Gut Microbiome to Reduce Colorectal Cancer Burden
Date Posted: April 29, 2025