https://prevention.cancer.gov

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience.

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Resources

Funding Opportunities

No matching Funding Opportunities were found.

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Grantee Details

PI Name	PI Organization	Title	Grant Number	Program Official
Shiozawa, Yusuke	Wake Forest University Health Sciences United States	Contribution of cutaneous neuro-immune interactions to chemotherapy-induced peripheral neuropathy	5R21CA297068-02	Rachel Altshuler, Ph.D.
Justilien, Verline	Mayo Clinic Jacksonville United States	ECT2 Isoform Switch in Pancreatic Cancer.	5R21CA296671-02	Matthew Young, Ph.D.
Damaj, M. Imad	Virginia Commonwealth University United States	Inhibition of NLRP3 inflammasome for the treatment of Chemotherapy-induced peripheral neuropathy	5R21CA296516-02	Rachel Altshuler, Ph.D.
Grossman, Douglas	Utah State Higher Education System--University Of Utah United States	Electrical impedance dermography as a biomarker for basal and squamous cell carcinoma	5R21CA289101-02	Nicholas Hodges, Ph.D.
Ah, Diane Marie Von	Ohio State University United States	Cognitive Training for Cancer-related Cognitive Impairment: A Multi-Center Randomized Controlled Trial	5R01CA276222-04	Brandy Heckman-Stoddard, Ph.D., M.P.H.
Kang, Dongkyun	University Of Arizona United States	Non-invasive, quantitative microscopic biomarkers for chemotherapy-induced peripheral neuropathy	1R01CA301271-01	Rachel Altshuler, Ph.D.
Clare, Susan E.	Northwestern University At Chicago United States	Lipid-initiated epigenetic reprogramming of the breast to a neural phenotype	1R21CA288676-01A1
Pistilli, Emidio Edward	West Virginia University United States	Targeting Muscle Fatigability During Cachexia	5R01AR079445-04	Brandy Heckman-Stoddard, Ph.D., M.P.H.
Greene, Nicholas Perry	University Of Arkansas At Fayetteville United States	DEVELOPMENT OF TARGETED APPROACHES IN PREVENTION OF CANCER-CACHEXIA	5R01AR075794-05	Brandy Heckman-Stoddard, Ph.D., M.P.H.
Chong, Catherine Daniela	Mayo Clinic Arizona United States	Biomarker Signature to Predict the Persistence of Post-Traumatic Headache	5R33NS113315-03	Brandy Heckman-Stoddard, Ph.D., M.P.H.
Duan, Bin	University Of Nebraska Medical Center United States	Flupirtine Analogue Synthesis and Screening for the Treatment of Chemotherapy-Induced Neuropathic Pain	1R21CA298918-01	Rachel Altshuler, Ph.D.
Crowder, Sylvia	H. Lee Moffitt Cancer Ctr & Res Inst United States	The MIND-BC Study: MIND diet for Breast cancer Cognition	1R01CA299480-01	Nancy J. Emenaker, Ph.D., RDN, LD, FAND
Eisenmann, Eric Daniel	Ohio State University United States	Damage-associated molecular patterns in chemotherapy toxicity	1R37CA299879-01	Rachel Altshuler, Ph.D.
Kolb, Noah Allan	University Of Vermont & St Agric College United States	Remote Monitoring of Management of Chemotherapy induced Peripheral Neuropathy	5R01CA247517-05	Brennan Streck, Ph.D., RN, M.P.H.
Groninger, J. Hunter	Medstar Health Research Institute United States	Cognitive behavioral theory-assisted virtual reality for chronic cancer pain (VR-CAN): device prototype development and feasibility testing	1R21CA299799-01	Brennan Streck, Ph.D., RN, M.P.H.

Clinical Trials

Title	Intervention	Sponsor	Status
Duloxetine to Prevent Oxaliplatin-Induced Peripheral Neuropathy in Patients With Stage II-III Colorectal Cancer	Duloxetine, Duloxetine Hydrochloride, Oxaliplatin, Placebo, Quality-of-Life Assessment, Questionnaire Administration	Alliance for Clinical Trials in Oncology	Active, not recruiting
Mobile Health and Social Media Physical Activity Intervention Among Adolescent and Young Adult Childhood Cancer Survivors, the StepByStep Study	Educational Intervention, FitBit, Goal Setting, Health Promotion and Education, Media Intervention, Telephone-Based Intervention	Children's Oncology Group	Active, not recruiting
Gut Microbe Composition, Exercise, and Breast Breast Cancer Survivors	Aerobic Exercise Training, Attention Control	University of Alabama at Birmingham	Active, not recruiting
A Text-based Intervention in Improving Adherence to Hormone Therapy in Patients With Stage I-III Hormone Receptor Positive Breast Cancer	Best Practice, Focus Group, Questionnaire Administration, Text Message	Thomas Jefferson University	Active, not recruiting
Learning Collaborative Versus Technical Assistance in Delivering a Palliative Care Program to Patients With Advanced Cancer and Their Caregivers	Behavioral, Psychological or Informational Intervention, Educational Intervention, Medical Examination Assessment, Quality-of-Life Assessment, Survey Administration, Telephone-Based Intervention	University of Rochester NCORP Research Base	Active, not recruiting
Taxane and Taxane-Induced Peripheral Neuropathy in African American Patients With Stage I-III Breast Cancer	Docetaxel, Paclitaxel, Quality-of-Life Assessment, Questionnaire Administration	ECOG-ACRIN Cancer Research Group	Active, not recruiting
Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer		Wake Forest University Health Sciences	Recruiting
Bupropion to Reduce Cancer Related Fatigue in Cancer Survivors	Biospecimen Collection, Bupropion Hydrochloride Controlled-release, Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration	University of Rochester NCORP Research Base	Active, not recruiting
Treatment Effects on Development of Chemotherapy-Induced Peripheral Neuropathy in Patients With Cancer	Chemotherapy, Functional Assessment, Questionnaire Administration	SWOG Cancer Research Network	Active, not recruiting
Axillary Reverse Mapping in Preventing Lymphedema in Patients With Breast Cancer Undergoing Axillary Lymph Node Dissection	Axillary Lymph Node Dissection, Isosulfan Blue, Mapping, Quality-of-Life Assessment, Questionnaire Administration	Alliance for Clinical Trials in Oncology	Active, not recruiting