Supportive Care and Symptom Management

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience.

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Resources

Funding Opportunities

Title	Announcement Number	Activity Code	Clinical Trials Status	Expiration Date	Program Official
HEAL Initiative: Studies to Enable Analgesic Discovery	RFA-NS-25-023 (R61/R33 - Clinical Trial Not Allowed)	R61, R33	Clinical Trial Not Allowed	02/20/2027	Rachel Altshuler, Ph.D.

Grantee Details

PI Name	PI Organization	Title	Grant Number	Program Official
Infante, Rodney E	Ut Southwestern Medical Center United States	Identifying the Cellular and Molecular Targets of JAK/STAT-Driven Adipose Wasting to Reverse Cancer Cachexia	3R01CA266900-04S1	Marjorie Perloff, M.D.
Kober, Kord Michael	University Of California, San Francisco United States	An Investigation of the Molecular Mechanisms for and Prediction of the Severity of Cancer Chemotherapy-Related Fatigue Using a Multi-staged Integrated Omics Approach	5R37CA233774-07	Brandy Heckman-Stoddard, Ph.D., M.P.H.
Geisler, Stefanie	Washington University United States	Developing mechanism-based strategies to treat chemotherapy-induced peripheral neuropathy	5R37CA267905-04	Asad Umar, D.V.M., Ph.D.
Washington, Karla	Washington University United States	Problem-Solving Therapy for Cancer Caregivers: A Randomized Clinical Trial in Outpatient Palliative Care	5R01CA258311-05	Brennan Streck, Ph.D., RN, M.P.H.
Valdimarsdottir, Heiddis	Icahn School Of Medicine At Mount Sinai United States	Systematic Light Exposure Effects on Circadian Rhythms Entrainment, Inflammation, Neutropenic Fever and Symptom Burden among Multiple Myeloma Patients undergoing Autologous Stem Cell Transplantation	5R01CA260961-04	Marjorie Perloff, M.D.
Kroetz, Deanna L	Ohio State University United States	Sphingolipid Signaling and Chemotherapy-Induced Peripheral Neurotoxicity	5R01CA261068-06	Rachel Altshuler, Ph.D.
Nolan, Michael Warren	North Carolina State University Raleigh United States	Evaluation of TRPM8-expressing neurons as novel regulators of acute radiotherapy-associated pain in patients with head and neck cancer	5R37CA248797-05	Asad Umar, D.V.M., Ph.D.
Sohl, Stephanie Jean	Wake Forest University Health Sciences United States	REmotely-delivered Supportive Programs for Improving surgical pain and disTrEss (RESPITE)	5R01CA266995-04	Goli Samimi, Ph.D., M.P.H.
Meghani, Salimah H.	University Of Pennsylvania United States	Cannabis use and outcomes in ambulatory patients with cancer: A 12-month cohort study	3R01CA270483-04S1	Gabriela Riscuta, M.D., CNS
Pyter, Leah M	Ohio State University United States	Chemotherapy-induced circadian master clock disruptions and fatigue	3R01CA270372-03S1	Marjorie Perloff, M.D.
Sorror, Mohamed	Fred Hutchinson Cancer Center United States	Novel Intervention Approaches to Alleviate Allogeneic Transplant-Related Morbidity and Mortality	5R01CA227092-06	Marjorie Perloff, M.D.
Milbury, Kathrin	University Of Tx Md Anderson Can Ctr United States	Dyadic yoga Program for Patients with Lung Cancer Undergoing Radiotherapy and their Family Caregivers	4R37CA231522-07	Brandy Heckman-Stoddard, Ph.D., M.P.H.
Plas, Ellen Van Der	Arkansas Children'S Hospital Res Inst United States	Identifying markers of abnormal neurocognitive trajectories during chemotherapy treatment of childhood acute lymphoblastic leukemia	5R37CA266135-04	Asad Umar, D.V.M., Ph.D.
Yu, Anthony Francis	Sloan-Kettering Inst Can Research United States	Intensive Blood Pressure Control During Cardiotoxic Breast Cancer Treatment (PROTECT) Trial	5R37CA273923-03	Eileen Dimond, R.N., M.S.
Bhatt, Vijaya Raj	University Of Nebraska Medical Center United States	Aging trajectories and outcomes of older adults with acute myeloid leukemia	5R37CA276928-03	Brennan Streck, Ph.D., RN, M.P.H.

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Clinical Trials

Title	Intervention	Sponsor	Status
Virtual Mental Health Intervention to Address Fear of Progression for Women With High Risk or Stage III-IV Gynecologic or Breast Cancer	Behavioral Intervention, Educational Intervention, Internet-Based Intervention, Interview, Survey Administration, Virtual Technology Intervention	City of Hope Medical Center	Not yet recruiting
Understanding Needs of Older Patients Prior to Starting Cancer Treatment	Assessment, Educational Intervention, Electronic Health Record Review, Internet-Based Intervention, Interview, Survey Administration	Wake Forest University Health Sciences	Enrolling by invitation
Surgical Thromboprophylaxis Practices in Oncology Patients Within the NCORP Network, STOP-VTE Study	Non-Interventional Study	Wake Forest University Health Sciences	Recruiting
Distance-Based Exercise to Preserve Function and Prevent Disability	Accelerometry, Aerobic Exercise Intervention, Dumbbell Exercise Intervention, Electronic Health Record Review, Exercise intervention, Interview, Questionnaire Administration, Telemedicine	Alliance for Clinical Trials in Oncology	Not yet recruiting
Xylitol Dental Wipes for the Reduction of Bloodstream Infection Risk in Children With Acute Myeloid Leukemia	Best Practice, Biospecimen Collection, Cytarabine, Electronic Health Record Review, Placebo Administration, Xylitol-containing Oral Wipe	Children's Oncology Group	Not yet recruiting
The MIND-BC Study: MIND Diet for Breast Cancer Cognition	MIND Diet, Usual Diet	H. Lee Moffitt Cancer Center and Research Institute	Recruiting
Mosaic Trial for Stem Cell Transplant Recipients	Enhanced Usual Care (Control) Website, Intervention website	Northwestern University	Recruiting
Communication About Sexual Health in Gynecologic Cancer	Sexual Health Resources, Starting the Conversation	Fox Chase Cancer Center	Recruiting
Lanreotide Versus Placebo Before Surgery to Prevent a Surgical Complication Called a Pancreatic Fistula	Biospecimen Collection, Distal Pancreatectomy, Lanreotide, Questionnaire Administration, Saline	SWOG Cancer Research Network	Recruiting
A Pilot Unrestricted Payment Program for Early-stage Cancer Patients: the PAYMENT Trial	Electronic Health Record Review, Interview, Support, Survey Administration	Fred Hutchinson Cancer Center	Not yet recruiting