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Supportive Care and Symptom Management

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

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About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience. 

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Funding Opportunities

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Grantee Details

PI Name PI Organization Title Grant Number Program Official
Somers, Tamara J

Duke University
United States

A Mobile Health Behavioral Pain Intervention Protocol for Breast Cancer Patients with Pain in Medically Underserved Communities: A Randomized Controlled Trial 5R01CA237892-05 Brennan Streck, Ph.D., RN, M.P.H.
Somers, Tamara J

Duke University
United States

A Mobile Health Behavioral Pain Intervention Protocol for Breast Cancer Patients with Pain in Medically Underserved Communities: A Randomized Controlled Trial 5R01CA237892-05 Brennan Streck, Ph.D., RN, M.P.H.
Maldonado, Fabien

Vanderbilt University Medical Center
United States

Novel Integrative Approach for the Early Detection of Lung Cancer using Repeated Measures 5R01CA253923-05
Zeng, Melody Yue

Weill Medical Coll Of Cornell Univ
United States

Dissecting the interplay between immunoglobulin G and the gut microbiome in cancer progression and metastasis 5R21CA270998-02 Young Kim, Ph.D.
Khan, Seema Ahsan

Northwestern University At Chicago
United States

Determinants of transdermal drug delivery to the normal and the radiated breast 5R01CA235647-05 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Sorror, Mohamed

Fred Hutchinson Cancer Center
United States

Novel Intervention Approaches to Alleviate Allogeneic Transplant-Related Morbidity and Mortality 5R01CA227092-06 Marjorie Perloff, M.D.
Sorror, Mohamed

Fred Hutchinson Cancer Center
United States

Novel Intervention Approaches to Alleviate Allogeneic Transplant-Related Morbidity and Mortality 5R01CA227092-06 Marjorie Perloff, M.D.
Sorror, Mohamed

Fred Hutchinson Cancer Center
United States

Novel Intervention Approaches to Alleviate Allogeneic Transplant-Related Morbidity and Mortality 5R01CA227092-06 Marjorie Perloff, M.D.
Wei, Lei

Roswell Park Cancer Institute Corp
United States

Advancing skin cancer prevention by tackling UV-induced clonogenic mutations 5R01CA255242-05 Wendy Wang, Ph.D., M.Sc.
El-Bayoumy, Karam E

Pennsylvania State Univ Hershey Med Ctr
United States

Chemoprevention by Black Raspberry of Oral Cancer Induced by Tobacco Carcinogens: Translational Studies 5R01CA173465-10 Gabriela Riscuta, M.D., CNS
Xiao, Yi

University Of Tx Md Anderson Can Ctr
United States

Exploring new strategy for breast cancer immunoprevention by targeting histamine receptor H1 5R21CA286318-02 Anda Vlad, M.D., Ph.D.
Perkins, Susan M

Indiana University Indianapolis
United States

Evaluation of the Communication Plan Early through End-of-Life (COMPLETE) Intervention 5R01CA235632-06 Brennan Streck, Ph.D., RN, M.P.H.
Perkins, Susan M

Indiana University Indianapolis
United States

Evaluation of the Communication Plan Early through End-of-Life (COMPLETE) Intervention 5R01CA235632-06 Brennan Streck, Ph.D., RN, M.P.H.
Palesh, Oxana G

Virginia Commonwealth University
United States

Multicenter Randomized Controlled Trial of Brief Behavioral Therapy for Cancer Related Insomnia 5R01CA239714-07 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Palesh, Oxana G

Virginia Commonwealth University
United States

Multicenter Randomized Controlled Trial of Brief Behavioral Therapy for Cancer Related Insomnia 5R01CA239714-07 Brandy Heckman-Stoddard, Ph.D., M.P.H.

Clinical Trials

Status
Title Sort ascending Intervention Sponsor Status
Treating Breast Cancer Patients Undergoing Trastuzumab Treatment With Carvedilol to Reduce Incidence of Heart Failure Carvedilol Mayo Clinic Active, not recruiting
To Evaluate if Green Tea Can be Effective in Reducing the Progression of Prostate Cancer in Men on Close Monitoring Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration, Sinecatechins ECOG-ACRIN Cancer Research Group Recruiting
The MIND-BC Study: MIND Diet for Breast Cancer Cognition MIND Diet, Usual Diet H. Lee Moffitt Cancer Center and Research Institute Recruiting
The Effect of Yoga on Nerve Pain Caused by Chemotherapy (Chemotherapy-Induced Peripheral Neuropathy) Education control, Usual care, Yoga Dana-Farber Cancer Institute Recruiting
Testing the Effects of MK-3475 (Pembrolizumab) With or Without the Usual Chemotherapy Treatment for Patients 70 Years of Age and Older With Advanced Non-small Cell Lung Cancer Carboplatin, Comprehensive Geriatric Assessment, Pembrolizumab, Pemetrexed, Quality-of-Life Assessment, Questionnaire Administration Alliance for Clinical Trials in Oncology Active, not recruiting
Testing the Effects of Exercise on Chemotherapy-Induced Peripheral Neuropathy Best Practice, Exercise Counseling, Exercise Intervention, Magnetic Resonance Imaging, Neuropathy Assessment, Questionnaire Administration University of Rochester NCORP Research Base Active, not recruiting
Testing the Application of Mepitel Film During Radiation Therapy to Reduce Radiation Related Redness and Peeling in Breast Cancer Patients Following Mastectomy Best Practice, Quality-of-Life Assessment, Questionnaire Administration, Wound Dressing Material Alliance for Clinical Trials in Oncology Active, not recruiting
Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer Best Practice, Biospecimen Collection, Cisplatin, Computed Tomography, Image Guided Radiation Therapy, Intensity-Modulated Radiation Therapy, Magnetic Resonance Imaging, MnSOD Mimetic BMX-001, Placebo Administration, Questionnaire Administration NRG Oncology Recruiting
Testing Laser Therapy for Treatment of Vaginal Dryness in Survivors of Breast Cancer, The Revitalize Trial Laser Therapy, Quality of Life Assessment, Questionnaire Administration, Sham Intervention Alliance for Clinical Trials in Oncology Not yet recruiting
Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability Biospecimen Collection, Magnetic Resonance Imaging, Memantine Hydrochloride, Neurocognitive Assessment, Stereotactic Radiosurgery, Survey Administration, Whole-Brain Radiotherapy NRG Oncology Recruiting