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Supportive Care and Symptom Management

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

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About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience. 

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Resources

Funding Opportunities

No matching Funding Opportunities were found.

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Grantee Details

PI Name PI Organization Title Grant Number Program Official
Jang, Mi-Hyeon

Rutgers Biomedical And Health Sciences
United States

Identification of novel biomarkers and therapeutic strategies in chemobrain. 5R01CA293210-02 John Clifford, Ph.D.
Xu, Chunhui

Emory University
United States

High-throughput assessment of chemotherapy-induced cardiotoxicity in 3D human cardiomyocytes 1R21CA285254-01A1 Eileen Dimond, R.N., M.S.
Lesch, Bluma J

Yale University
United States

Defining signatures of epigenetic sensitization to lung cancer in a mouse model 5R21CA288677-02 Guillermo Marquez, Ph.D.
Mahan, Kristin Eckel

University Of Texas Hlth Sci Ctr Houston
United States

Circadian regulation of astrocytic adenosine kinase in the irradiated and cancer brain 1R21CA292148-01 John Clifford, Ph.D.
Yang, Qing

University Of Texas Med Br Galveston
United States

The role of acute excitation of sensory neurons in the development of paclitaxel-induced peripheral neuropathy 5R01CA273001-02 Rachel Altshuler, Ph.D.
Schaverien, Mark V

University Of Tx Md Anderson Can Ctr
United States

Lymphedema Prevention Through Immediate Lymphatic Reconstruction 5R01CA292908-02 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Boone, Anna

University Of Missouri-Columbia
United States

Pilot testing of metacognitive strategy training to address cancer-related cognitive impairment in breast cancer 1R21CA286404-01A1 Marjorie Perloff, M.D.
Rini, Christine

Northwestern University At Chicago
United States

Mosaic: RCT of a Digital Health Intervention Delivering Peer Support Narratives and Psychoeducation to English- and Spanish-Speaking Stem Cell Transplant Recipients 5R01CA292116-02 Brennan Streck, Ph.D., RN, M.P.H.
Winger, Joseph Giles

Duke University
United States

Engage: A Randomized Controlled Trial Testing the Efficacy of a Telehealth-Delivered Psychosocial Intervention to Decrease Symptom Interference in Patients with Advanced Cancer 5R01CA291768-02 Brennan Streck, Ph.D., RN, M.P.H.
Flynn, Kathryn E

Medical College Of Wisconsin
United States

Symptom Monitoring using Patient-Reported Outcomes to Optimize Medication Use (SyMPTOM) 5R01CA285925-02 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Reb, Anne

Beckman Research Institute/City Of Hope
United States

A Blended e-Health Intervention for Fear of Progression in Advanced GYN Cancer 1R21CA293326-01 Brennan Streck, Ph.D., RN, M.P.H.
Gonzalez, Brian D

H. Lee Moffitt Cancer Ctr & Res Inst
United States

Impact of Targeted Therapy on Cancer-Related Cognitive Impairment 5R01CA287666-02 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Bartolini, Francesca

Columbia University Health Sciences
United States

Investigating the Pathogenic Role of Tubulin Post-translational Modifications in CIPN 5R01CA279401-02 Rachel Altshuler, Ph.D.
Marker, Ryan J

University Of Colorado Denver
United States

Effects of a telehealth exercise program for rural cancer survivors with cancer-related fatigue including integrated longitudinal assessments of objective physical function and fatty acid oxidation 5R01CA292482-02 Goli Samimi, Ph.D., M.P.H.
Kleckner, Amber Simmons

University Of Maryland Baltimore
United States

Time-restricted eating to address cancer-related fatigue among survivors of hematological malignancies 5R01CA284082-02 Brandy Heckman-Stoddard, Ph.D., M.P.H.

Clinical Trials

Status
Title Intervention Sponsor Status Sort descending
Testing Laser Therapy for Treatment of Vaginal Dryness in Survivors of Breast Cancer, The Revitalize Trial Laser Therapy, Quality of Life Assessment, Questionnaire Administration, Sham Intervention Alliance for Clinical Trials in Oncology Not yet recruiting
A Pilot Unrestricted Payment Program for Early-stage Cancer Patients: the PAYMENT Trial Electronic Health Record Review, Interview, Support, Survey Administration Fred Hutchinson Cancer Center Not yet recruiting
Xylitol Dental Wipes for the Reduction of Bloodstream Infection Risk in Children With Acute Myeloid Leukemia Best Practice, Biospecimen Collection, Cytarabine, Electronic Health Record Review, Placebo Administration, Xylitol-containing Oral Wipe Children's Oncology Group Not yet recruiting
Distance-Based Exercise to Preserve Function and Prevent Disability Accelerometry, Aerobic Exercise Intervention, Dumbbell Exercise Intervention, Electronic Health Record Review, Exercise intervention, Interview, Questionnaire Administration, Telemedicine Alliance for Clinical Trials in Oncology Not yet recruiting
New Assessment System in Measuring Symptom Distress in Cancer Patients Interview, Quality-of-Life Assessment, Questionnaire Administration M.D. Anderson Cancer Center Recruiting
Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer Wake Forest University Health Sciences Recruiting
Improving Adolescent and Young Adult Self-Reported Data in ECOG-ACRIN Trials Questionnaires Eastern Cooperative Oncology Group Recruiting
Reaching Rural Cancer Survivors Who Smoke Using Text-Based Program Health Promotion and Education, Informational Intervention, Questionnaire Administration, Smoking Cessation Intervention Alliance for Clinical Trials in Oncology Recruiting
Olanzapine Versus Megestrol Acetate for the Treatment of Loss of Appetite Among Advanced Cancer Patients Megestrol Acetate, Olanzapine, Questionnaire Administration Alliance for Clinical Trials in Oncology Recruiting
Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability Biospecimen Collection, Magnetic Resonance Imaging, Memantine Hydrochloride, Neurocognitive Assessment, Stereotactic Radiosurgery, Survey Administration, Whole-Brain Radiotherapy NRG Oncology Recruiting