There are 3 new funding opportunity announcements about the Pre-Cancer Atlas associated with the Beau Biden Cancer MoonshotSM Initiative that are intended to accelerate cancer research. The purpose of the FOAs is to promote research that results in a comprehensive view of the dynamic, multidimensional tumor ecosystem and is a direct response to the Moonshot Blue Ribbon Panel recommendation to generate human tumor atlases.
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For the purposes of these FOAs, a human pre-cancer atlas is defined as a multidimensional cellular, morphological and molecular mapping of human pre-malignant tumors, complemented with critical spatial information (at cellular and/or molecular level) that facilitate visualization of the structure, composition, and multiscale interactions within the tumor ecosystem over time resulting in progression or regression of the tumors.
The tumor atlases will be developed by the Human Tumor Atlas Network (HTAN), which will include the Pre-Cancer Atlas (PCA) Research Centers (solicited under RFA-CA-17-035), the Human Tumor Atlas (HTA) Research Centers (solicited under RFA-CA-17-034), an HTAN Data Coordinating Center (solicited under RFA-CA-17-036), and an HTAN Tissue Coordinating Center (anticipated to be developed in Fiscal Year 2019).
The PCA Research Centers will work in collaboration to construct comprehensive, dynamic, high-resolution, multidimensional, multiparametric, temporal and scalable atlases of pre-cancerous lesions and their surrounding microenvironment for select organ sites, including high-priority cancers that disproportionally affect minority and underserved patients. A deeper understanding of the transition from pre-malignant to malignant state as a function of time will allow the development of more precise risk stratification methods and effective early intervention strategies.
Each PCA Research Center will lead the construction of at least one human pre-cancer atlas for use by the research and clinical communities. The data and analytical tools generated by the PCA Research Centers will be made available to the research community through the aid of the HTA Data Coordinating Center.