Volume 8, Issue 2
The spring issue of Nutrition Frontiers showcases the calcium/magnesium intake ratio in colorectal adenoma, the role of PPARγ in metabolism and reproduction, and the effects of time-restricted feeding on metabolic parameters. Meet our spotlight investigator, Dr. Maria Cruz-Correa, and her research on gut bacterial genes, diet, and colorectal neoplasia. Learn about matcha, the powdered leaf tea, upcoming announcements and more.
RESEARCH UPDATE: ON THE CLINICAL FRONT
Calcium/Magnesium Intake Ratio Interacts with Polymorphism Associated to Colorectal Neoplasia
RESEARCH UPDATE: WHAT’S NEW IN BASIC SCIENCE
Neuronal PPARγ Involved in Adverse Effects of Diet-Induced Obesity
Peroxisome-proliferator activated receptor (PPARγ) regulates adipocyte differentiation, lipid and glucose homeostasis, and control of inflammatory responses. The effects of PPARγ in reproduction are less known. In a recent study, Fernandez and colleagues created a deletion of PPARγ in mature neurons (brain-knockout, BKO) in female mice to investigate the role of neuronal PPARγ in metabolism and reproduction. Although the deletion of PPARγ did not alter the timing of puberty in female mice, fertility was impaired. When the mice were challenged with a 60% high-fat diet, the BKO mice had the expected alterations in body weight, glucose and insulin tolerance, and leptin levels but were protected from obesity-induced leptin resistance; the BKO mice also were protected from obesity-induced estrous cycle impairment. Further detailed studies using genetic deletions in specific neuronal populations will be necessary to dissect the individual contributions of PPARγ to leptin resistance and reproductive function in obesity.
The Stars in Nutrition and Cancer lecture, Aflatoxin: An Old Carcinogen Teaches Us New Tricks, by John D. Groopman, PhD, Johns Hopkins University is now available for viewing here.
Couldn’t make it to the John Milner Nutrition and Cancer Prevention Research Practicum in March, then read one attendee’s testimonial for an in-depth perspective.
May 22-25, 2017
Workshop on Nutrigenetics, Nutrigenomics and Precision Nutrition
May 25-26, 2017
Emerging Role of Branched-Chain Amino Acids in Human Diseases
National Institute of Diabetes and Digestive and Kidney Diseases, NIH
June 13-14, 2017
Workshop on Best Practices for Studies of Diet and the Intestinal Microbiome
NIH Campus and webcast.
In-person registration is full. However, registration to view the meeting via webcast is available. Register by emailing Diet-Microbiome-Workshop@ars.usda.gov
July 20-24, 2017
Society for Nutrition Education and Behavior 50th Annual Conference
October 21-25, 2017
Food and Nutrition Conference and Expo
December 5-6, 2017
NIH Pathways to Prevention Workshop: Methods for Evaluating Natural Experiments in Obesity
Time-Restricted Feeding Improves Metabolic Parameters in Postmenopausal Obesity Mouse Model
Time-restricted feeding (TRF) is the practice of restricting the time of calorie intake, rather than the amount of calorie intake, to a specific period in the normal circadian rhythm. TRF is an alternative approach to caloric restriction for metabolic disease and cancer prevention that might have better compliance. Chung and colleagues tested TRF as an intervention in a mouse model of postmenopausal obesity. Ovariectomized mice were fed either normal low fat chow or a high fat diet ad libitum for 9 weeks after which the high fat-fed group was split into ad libitum and TRF high fat-fed groups. Despite having 8-hour access to the same high fat diet as ad libitum-fed mice, TRF mice experienced rapid weight loss followed by weight stabilization, delayed improvement in insulin resistance, amelioration of hepatosteatosis, and beneficial modulation of hepatic gene expression. Further long-term animal studies are being pursued to define the molecular basis for the beneficial effects of TRF on metabolism.
SPOTLIGHT INVESTIGATOR: MARCIA CRUZ-CORREA
Did You Know?
Matcha: The Powdered Leaf
Catechins, amino acids, and saponins in matcha contribute to the foaming observed in the mindful ritual of preparing and consuming it in Japanese tea ceremonies. Whether you try matcha as a replacement to coffee or as a pick-me-up addition to a smoothie — it can be a refreshing culinary addition to all types of foods, including desserts!
Try Traditional Ceremonial Grade Matcha:
- Combine 1-3 teaspoon(s) of matcha green tea powder with a small amount of hot water.
- Stir or whisk with a chasen, a traditional bamboo whisk, to create a bright emerald green paste.
- Add additional hot water and whisk until foam is observed. Whisking promotes the extraction of the catechins, in particular, epigallocatechin gallate and caffeine.
- Savor and sweeten to taste.