Trial NCT02717507

Carvedilol in Preventing Heart Failure in Childhood Cancer Survivors

This randomized phase IIb trial studies how well low-dose carvedilol works in preventing heart failure in cancer survivors exposed to high dose anthracyclines for management of childhood cancer. Patients who received high-dose anthracycline chemotherapy are at a much greater risk for developing heart failure compared to survivors who didn?t get any anthracycline chemotherapy. Heart failure happens when the heart muscle has been weakened and can?t pump blood as well as it should. Carvedilol may help lower the risk of cardiovascular complications.

Intervention

Carvedilol, Laboratory Biomarker Analysis, Pharmacological Study, Placebo, Quality-of-Life Assessment, Questionnaire Administration, Pharmacogenomic Study

Condition

Cancer Survivor

Investigators

Saro H. Armenian, Madhu S. Gowda, Mariko Sato, Eduard H. Panosyan, Alexandra M. Walsh, Laura A. Campbell, Carola A. Arndt, Robert M. Cooper, Elyssa M. Rubin, Lisa L. Hartman, Douglas J. Scothorn, Anne-Marie R. Langevin, Conrad V. Fernandez, Juan F. Rico, Ashok B. Raj, Mary L. Schmidt, Michael K. Richards, Craig Lotterman, Douglas S. Hawkins, Ramamoorthy Nagasubramanian, Steven J. Kuerbitz, Smita Bhatia, Anthony F. Yu, Emad K. Salman, Nino C. Rainusso Guainazzo, William S. Ferguson, Alan K. Ikeda, William B. Slayton, Marianne B. Phillips, Jason M. Fixler, Leo Mascarenhas, Debra L. Friedman, Rajaram Nagarajan, Denise A. Rokitka, Keith J. August, Michael B. Harris, Rajen Mody, Narayana Gowda, Jean M. Tersak, Nichole L. Bryant, Daniel C. Bowers, Wade T. Kyono, Rene Y. McNall-Knapp, Tara O. Henderson, Anderson (Andy) B. Collier, Laura E. Hogan, Donald T. Beam, Janice F. Olson, Mark E. Weinblatt, Jonathan D. Fish, Rebecca E. McFall, William D. Roberts, Judy L. Felgenhauer, William C. Petersen, Fouad M. Hajjar, Mark A. Winstanley, Kelly W. Maloney, Karen E. Effinger, Bassem I. Razzouk, David L. Becton, Jennifer J. Clark, Jennifer L. Reichek, Melissa M. Hudson, Jeffrey S. Dome, Jill P. Ginsberg, Karim T. Sadak, Alissa Kahn, Jeffrey A. Toretsky, Andrew J. Dodgshun, Angela R. Girvin, Lolie C. Yu, Dana A. Obzut, Samantha L. Mallory, Jacqueline M. Kraveka

See list of participating sites