Supported Projects

Supported Approaches

PREVENT supports these approaches to prevention:

  • Immunoprevention (e.g. vaccines for cancers associated or not associated with infectious agents; immunomodulatory agents, etc.)
  • Novel mechanisms (e.g. targeting oncogenic signaling pathways; targeting cancer promoting substances; promoting microbiota restoration, etc.)
  • Clinically translatable biomarkers of tumor progression and/or prevention efficacy
  • Anti-inflammatory approaches
  • Drug repurposing
  • Reducing toxicity (optimization of dosing, scheduling, and combinations)

PREVENT Cycles 1 through 13

47 Small molecule projects; 21 Vaccine projects; 8 Biomarker projects

Jump to: Bladder | Breast | Cervical & Other HPV Cancers | Colon | Lung | Ovary | Pancreas | Prostate | Other Cancers | GMP Production

Cancer Type Type of Agent Project Description
Bladder Small Molecule Evaluation of Agents/Protocols that Inhibit Two Major Pathways Involved in Human Urinary Bladder Cancer (PI3K, EGFR) and Protocols to Reduce Their Toxicity

Prevention of Urinary Bladder Cancer with Two "Clinically-Ready" Agents (Everolimus and Naproxen) When Administered in Combination
Vaccine Multi-antigen Vaccines for the Primary and Secondary Prevention of Bladder Cancer
Breast Small Molecule Evaluation of GLG-302, a STAT3 Antagonist, in the Prevention of Mammary Cancer

Efficacy of Metformin in the Methylnitrosourea-induced Model of ER+ Mammary Carcinogenesis when Animals are Placed on Different Diets: Standard Diet, High Fat Diet, and High Fructose Diet

Evaluation of the Prevention by ACTOPLUS/MET (Pioglitazone and Metformin) of ER+ and ER- Mammary Cancers Occurring in Rodents on a High-Fat Diet

Effect of Bazedoxifene Either Alone or in Combination with an Aromatase Inhibitor or Conjugated Estrogens (CE) in the Prevention of Mammary Cancers

Evaluation of the Cancer Prevention Efficacy of GLG-302

Support for Endoxifen Gel Clinical Development

Examination of a Putative Modulator of Glucose and Energy Metabolism for Mammary Cancer

Targeted casein kinase 1ë (CK1ë) inhibition as a breast cancer prevention strategy

Evaluation of "Clinical-Ready" Agents (Bazedoxifene and Erlotinib) in Combination for the Prevention of ER+ and ER Mammary Cancers

Targeting the mTOR/TORC Pathway for the Prevention of Breast Cancer
Biomarker Chemopreventive Effects in Both Standard Chow Diets and High Fat Diets of Known Positive and Negative Chemopreventive Agents Employing Both High Risk (But Histologically Normal) Mammary Epithelium and Mammary Cancers Including Correlative Biomarkers

Blood-based Biomarkers of Obesity-Induced Breast Inflammation
Vaccine AAV1-Plac1 Vaccine Platform for Cancer Prevention

Efficacy of a Multi-Antigen Vaccine in the Prevention of MNU-induced Mammary Cancers ER Positive in Female SD Rats

Development of a Multi-antigen, Multi-peptide Vaccine based on Gene Expression Information to Prevent Triple Negative Breast Cancer in a Mouse Model

Evaluating Whether Concurrent 9cUAB30 Rexinoic Acid Receptor Agonist and HER2-IGFBP2-IGF1R Vaccine Can Enhance Treatment of Ductal Carcinoma In Situ and Prevention of Invasive Breast Cancer
Cervical and Other HPV Cancers Small Molecule Nonclinical Safety, Toxicokinetic, and Stability Evaluation of Bioresponse Diindolylmethane Vaginal Cream for Topical Treatment of Cervical Intraepithelial Neoplasia (CIN)
Vaccine Safety Evaluation of pNGVL4a-CRT-E6E7L2 (detox) Recombinant DNA Vaccine in Mice

Support for HPV16L1/RG1 Chimeric Virus-Like Particle Vaccine Clinical Development
Colon Small Molecule Preclinical Development of mPGES-1 and 5-LOX Selective Inhibitors for Chemoprevention

Efficacy of Aspirin and Naproxen (Short-term Frequent Dosing) in Colorectal Cancer Models

Combination of Aspirin and Omeprazole for Colorectal Cancer Chemoprevention

NSAID Chemoprevention in Colorectal Cancer

Efficacy of Eldecalcitol (ED-71) in Colorectal Cancer Prevention in Apc^Min Mice Model

Immunogenic Effects of NSAIDs with and without a Caccine in Colon Cancer Prevention

ONC201 in a High Risk CRC Immuneprevention Model

Combination of Aspirin or Naproxen with Omeprazole for Colorectal Cancer Chemoprevention with Clinically Relevant Doses

Determination of Dosing Regimens of Erlotinib in Combination with Sulindac for Prevention of Colorectal Cancer While Reducing Agent Toxicity.

Chemoprevention of Colorectal Cancer with Olmesartan Medoxomil

A Novel Non-COX inhibitory Sulindac Derivative for Colorectal Cancer Chemoprevention with Selective PDE10 and Wnt/b-Catenin Inhibitory Activity
Biomarker Effect of a Chemopreventive Agent on the Fecal Metabolite Profile in Intestinal Neoplasia

Molecular Heterogeneity of Inflammation and Growth Factor Pathways in Sporadic and Syndromic Colon Cancers: Implications for Prevention and Therapeutic Trials
Vaccine Characterization of Potential Antigens for Immunization Against Colon Cancer and Testing Multivalent Tumor Vaccines in Min Mice

Anti-Fusobacterium nucelatum Vaccine for Colorectal Cancer Immunoprevention

Testing of Combination Immuno- and Chemoprevention Strategies for Lynch Syndrome
Lung Small Molecule In Vivo Evaluation of a Chemopreventive Agent, Ciclesonide, in Mouse Lung Tumor Model by Inhalation

Anti-inflammatory Effects of Fixed Dose Combination of Pioglitizone and Metformin for Lung Cancer Prevention

Effects of Weekly or Intermittent Dosing Regimens of EGFR, MEK and PI3K Inhibitors in Mouse Models of Lung Cancer

Lung Cancer Chemoprevention by microRNA Delivery

Chemoprevention with Aerosolized Bexarotene in Mouse Models of All Three Major Subtypes of Lung Cancer: Adenocarcinoma, Squamous Cell Carcinoma and Small Cell Lung Cancer
Biomarker Modulation of Cigarette Smoke-induced Alterations in microRNA Expression and Lung Tumors in Mice Treated with Aspirin and Naproxen

Effects of Chemopreventive Agents on Biomarkers Related to Lung Tumorigenesis: Alterations in Normal Lung, At Risk Lung and Lesions

Modulation of miRNA Expression in Blood or Other Biological Fluids Compared with Tissue Levels in Mice Exposed to Cigarette Smoke and/or with NSAIDs

Examination of Exosomal miRNAs as Potential Biomarkers for Chemopreventive Efficacy in Mouse Models of Lung Squamous Cell Carcinoma
Vaccine Use of TERT Vaccine in Prevention of Lung Cancer in Animal Models

Multi-Antigen Vaccine for Lung Cancer Prevention

Development of Multiantigen Vaccines to Prevent the Development of Lung Adenocarcinomas Driven by either K-RAS or EGFR Oncoproteins in Mice

Rational Design and Development of a Multi-Antigen Multi-Peptide Vaccine Based on Genomic Information to Prevent Lung Cancer Initiation and Progression
Ovary Small Molecule Ovarian Cancer Chemoprevention

Ovarian Cancer Chemoprevention
Vaccine Mesothelin Vaccination for the Prevention of Ovarian Cancer

Optimization and Further Development of Mesothelin Vaccine for the Prevention of Ovarian Cancer
Pancreas Small Molecule Targeting P2X7 Receptor Antagonists for Prevention of Pancreatic Cancer

Targeting CCK2R for Pancreatic Cancer Prevention

Preclinical Studies to Evaluate the Combination of Metformin and Aspirin for the Prevention of Pancreatic Cancer

Optimization of GEM Models for High-Risk Cohorts of Human Pancreatic Cystadenomas, IPMNs and PanINs Progression to PDAC
Vaccine Development of Muc1 Vaccine for the Prevention of Pancreatic Cancer

Cancer Prevention by à-Enolase Vaccination

Effect of a Multipeptide Kras Vaccine in the Prevention of Pancreatic Cancer Driven by Kras Oncoprotein in Ikras Mice
Prostate Small Molecule Chemoprevention of Prostate Cancer via Estrogen Receptor β Agonists

Novel Androgen Receptor Antagonist-Mediated Chemoprevention of Prostate Cancer in Preclinical Model

Preclinical Evaluation of a New Lipid-Based SMEDDS BR-9001 Formulation

Prostate Cancer Prevention by Aspirin and/or Other NSAIDs

Preclinical Development of Chemopreventive agent 4-methylumbelliferone
Other Cancers Small Molecule Chemoprevention of Endometrial Hyperplasia and Its Transition to Endometrial Cancer with NSC 721689

Targeting the IL-6 Signaling Pathway as Chemopreventative Therapy for High-Risk Malignant Mesothelioma Populations

Oral Cancer Chemoprevention by Inhibitors of Inducible Nitric Oxide Synthase (iNOS)

Chemoprevention of Esophageal Cancer by Targeting Multiple Pathways in a Mouse Model of Barrett's Esophagus

Prevention of Hepatocellular Carcinoma (HCC) Associated with Non Alcoholic Steatohepatitis (NASH)
Vaccine A Polyvalent Vaccine Against Fusion Proteins Observed in Solid Tumors
GMP Production Small Molecule Large Scale Synthesis of 9-CIS-UAB30 to Support Translational Development of This Novel Chemopreventive Rexinoid

cGMP NSC 721689 Production for IRB-approved and NCI- funded Clinical Trials
Vaccine cGMP Production of a Chimeric Virus-Like Particle Vaccine (RG1-VLP) for Prevention of HPV-Associated Cancers