This randomized phase IIB trial studies how well tamoxifen or afimoxifene works in treating patients with estrogen receptor positive breast cancer. Estrogen can cause the growth of breast cancer cells. Hormone therapy using tamoxifen citrate or afimoxifene may fight breast cancer by blocking the use of estrogen by the tumor cells.
Afimoxifene, Laboratory Biomarker Analysis, Placebo, Tamoxifen Citrate
Ductal Breast Carcinoma In Situ, Estrogen Receptor Positive
Seema A. Khan, MD, Melissa L. Pilewskie, MD, Joseph M. Guenther, MD, Stephen R. Grobmyer, MD, Eun-Sil (Shelley) Hwang, MD, Amy C. Degnim, MD