This phase IIa trial studies how well metformin hydrochloride works in preventing oral cancer
in patients with an oral premalignant lesion (oral leukoplakia or erythroplakia). Oral
premalignant lesions look like red or whitish plaques or lesions in the mouth that do not rub
off and can be associated with a higher risk of cancer. Metformin hydrochloride may help
prevent oral cancer from forming in patients with an oral premalignant lesion.
Erythroplakia, Hyperplasia, Mild Dysplasia, Moderate Dysplasia, Oral Cavity Carcinoma, Oral Leukoplakia, Severe Dysplasia