This randomized, pilot phase I trial studies the side effects of berberine chloride in
treating patients with ulcerative colitis and who are in remission (a decrease in or
disappearance of signs and symptoms of cancer) to reduce the risk of colorectal cancer.
Patients with ulcerative colitis are at increased risk for colorectal cancer. Chemoprevention
is the use of drugs, such as berberine chloride, to keep a disease/condition from forming or
coming back. The use of berberine chloride may keep colorectal cancer from forming in
patients with ulcerative colitis.