Clinical Trials Program

Breast

• A Multicenter Phase II Study of Docosahexaenoic Acid (DHA) in Triple Negative Breast Cancer Survivors
• Letrozole in Treating Healthy Postmenopausal Women at High Risk for Breast Cancer

Colon

• A Trial of Metformin for Colorectal Cancer Risk Reduction Among Patients With a History of Colorectal Adenomas and Elevated Body Mass Index
• Polyethylene Glycol 3350 in Preventing Cancer in Patients at Risk of Colorectal Cancer
• Inositol in Preventing Colorectal Cancer in Patients With Colitis-Associated Dysplasia
• Phase I, Randomized Placebo-Controlled Trial of Linaclotide to Demonstrate Colorectal Bioactivity in Healthy Volunteers

Esophagus

• Ursodiol in Treating Patients With Barrett Esophagus and Low-Grade Dysplasia

Head and Neck

• Phase IIB Randomized, Placebo Controlled Trial of Pioglitazone for Oral Premalignant Lesions: An Inter-Consortium Study

Lung

• Inositol in Preventing Lung Cancer in Current or Former Smokers With Bronchial Dysplasia

Other

• A Randomized, Double-blind, Phase I Dose-escalation Study of the Novel Retinoic 9cUAB30

Prostate

• Phase II Study of Metformin in a Pre-prostatectomy Prostate Cancer Cohort

Esophagus

• Erlotinib Hydrochloride in Treating Patients With Previously Treated Non-Small Cell Lung Cancer, Head and Neck Cancer, or Esophageal Cancer and Precancerous Lesions of the Lung
• Metformin Hydrochloride in Preventing Esophageal Cancer in Patients With Barrett Esophagus

Liver

• S-Adenosyl-L-Methionine Disulphate P-Toluene-Sulfonate in Preventing Liver Cancer in Patients With Chronic Hepatitis C Infection

Lung

• Erlotinib Hydrochloride in Treating Patients With Previously Treated Non-Small Cell Lung Cancer, Head and Neck Cancer, or Esophageal Cancer and Precancerous Lesions of the Lung
• Natural History of Lung Nodules Seen on CT Scans From Participants at High-Risk of Developing Lung Cancer

(When results are published, the trial moves to publications.)

Bladder

• Green Tea Extract in Treating Patients With Nonmetastatic Bladder Cancer

Breast

• 4-Hydroxytamoxifen or Tamoxifen Citrate in Treating Women With Newly Diagnosed Ductal Breast Carcinoma in Situ
• A Phase I Prevention Study of Atorvastatin in Women at Increased Risk for Breast Cancer
• Acolbifene for Breast Cancer Chemoprevention

Colon

• Aspirin in Preventing Colorectal Cancer in Patients at Increased Risk of Colorectal Cancer
• Erlotinib Hydrochloride in Treating Patients With Stage I-III Colorectal Cancer or Adenoma

Esophagus

• Defined Green Tea Catechin Extract in Preventing Esophageal Cancer in Patients With Barrett's Esophagus

Lung

• Zileuton With or Without Celecoxib As Chemopreventive Agents in Smokers

Prostate

• Finasteride in Treating Patients With Stage II Prostate Cancer Who Are Undergoing Surgery

Skin

• Vitamin D Levels in the Skin of Healthy Subjects After Oral Supplementation

Biomarker & Dose-Finding Studies

• Resveratrol in Postmenopausal Women With High Body Mass Index