Trial NCT04251052

A Study to Compare Two Surgical Procedures in Women With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

This trial studies how well two surgical procedures (bilateral salpingectomy and bilateral
salpingo-oophorectomy) work in reducing the risk of ovarian cancer for women with BRCA1
mutations. Bilateral salpingectomy involves the surgical removal of fallopian tubes, and
bilateral salpingo-oophorectomy involves the surgical removal of both the fallopian tubes and
ovaries. This study may help doctors determine if the two surgical procedures are nearly the
same for ovarian cancer risk reduction for women with BRCA1 mutations.

Intervention

Bilateral Salpingectomy, Bilateral Salpingectomy with Oophorectomy, Quality-of-Life Assessment, Questionnaire Administration

Condition

Ovarian Carcinoma

Investigators

Douglas A Levine, Gregory A. Masters, Georgina Cheng, Shannon MacLaughlan, Samir D. Undevia, Gustavo C. Rodriguez, John M. Schallenkamp, Nicola M. Spirtos, Eugenia Girda, Carolyn Y. Muller, Douglas A. Levine, Richard L. Deming, Jeffrey W. Elder, David S. Miller, Kari L. Ring, Matthew L. Ryan, Lisa M. Barroilhet, William H. Bradley, Charles A. Leath, Ramey D. Littell, Beth Y. Karlan, Guilherme Henrique C. Cantuaria, Howard A. Zaren, Emma Barber, Kathryn A. Mills, David P. Bender, Kevin M. Schuler, Leslie S. Bradford, Dana Zakalik, Ira S. Winer, Kathleen J. Yost, Emily N. Prendergast, Gretchen E. Glaser, Bryan A. Faller, Jay W. Carlson, Brent J. Tierney, Kerry J. Rodabaugh, Kara C. Long Roche, Richard G. Moore, Michael G. Kelly, Mariam M. AlHilli, Joan L. Walker, Krishna C. Alluri, Colleen C. McCormick, Alexander B. Olawaiye, Mark S. Shahin, Jennifer S. Wilbur, Carlton L. Schwab, Neil T. Phippen, Stephanie Sullivan, Setsuko K. Chambers, Scott E. Lentz, Lindsay Brubaker, Marguerite (Meg) L. Palisoul, Pamela J. Stone, Joyce Varughese, Sareena Singh, William E. Luginbuhl

See list of participating sites