Trial NCT04137107

Duloxetine to Prevent Oxaliplatin-Induced Peripheral Neuropathy in Patients With Stage II-III Colorectal Cancer

This phase II/III trial studies the best dose of duloxetine and how well it works in
preventing pain, tingling, and numbness (peripheral neuropathy) caused by treatment with
oxaliplatin in patients with stage II-III colorectal cancer. Duloxetine increases the amount
of certain chemicals in the brain that help relieve depression and pain. Giving duloxetine in
patients undergoing treatment with oxaliplatin for colorectal cancer may help prevent
peripheral neuropathy.

Intervention

Duloxetine, Duloxetine Hydrochloride, Oxaliplatin, Placebo, Quality-of-Life Assessment, Questionnaire Administration

Condition

Stage II Colorectal Cancer AJCC v8, Stage III Colorectal Cancer AJCC v8

Investigators

Ellen M. Lavoie Smith, PhD, Thomas W. Butler, Alison K. Conlin, Richard L. Deming, Jay W. Carlson, Lisa Bailey, Bogdan S. Eftimie, Robert J. Hoyer, Wylie D. Hosmer, Salvatore A. Del Prete, Gregory A. Masters, Mohamedtaki A. Tejani, Elie G. Dib, John M. Schallenkamp, Suparna Mantha, Bryan A. Faller, Asha R. Dhanarajan, Sheetal M. Kircher, Thomas E. Lad, John D. Abad, Robert d. Marsh, Mark F. Kozloff, Isoken Koko, Shylendra B. Sreenivasappa, Howard M. Gross, Debra M. Prow, William P. Fusselman, Deborah W. Wilbur, Shaker R. Dakhil, Gary C. Doolittle, David S. Hanson, Rachit Kumar, Sarah J. Sinclair, Gang Chen, Ashkan Bahrani, Marianne T. Huben, Preston D. Steen, David M. King, Joleen M. Hubbard, Timothy Huyck, Ursa A. Brown-Glaberman, Jeffrey J. Kirshner, Eric Bravin, Samer S. Kasbari, Jordan Kharofa, Sagila George, Paul E. O'Brien, Asheesh Shipstone, Timothy L. Cannon, Zhijian Chen, Mohammed Saad, William J. Irvin, Xin Yao, Francis J. Cuevas, Adedayo A. Onitilo, Sameer Tolay, Anthony J. Jaslowski, Timothy R. Wassenaar, Joni A. Tilford, Donald J. Jurgens, Steven Ades, John J. Inzerillo, Camille Adeimy, Jason C. Lee, Thomas J. Summers, Joshua Lukenbill, Namita Sharma, Ki Y. Chung, Kathryn M. Leininger, Grant R. Williams, Dhruv Bansal, Carl J. Minniti, Ali Bukhari, Jeffrey L. Berenberg, Sanjay Goel, Richard J. Bold, Joyson Poulose, John A. Ellerton, Alexander Menter, Leon C. Hwang, Anteneh A. Tesfaye, Akm Mosharraf Hossain, Sharad A. Ghamande, Lawrence E. Feldman, Muhammad O. Toor, Marshall P. Stagg, Lingling Du, Adam J. Goldrich, Joseph L. Pennacchio, James M. Koomey, Kathleen J. Yost, Mark A. Klein, Sung Ho B. Lee, Jennifer L. Heaberlin, Praveen Vashist, Adarsh Vennepureddy, Joel N. Saltzman, Dennis Hsu, Steven J. Cohen, Om N. Pandey, Nour Daboul

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