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Workshop Report: Modulation of Antitumor Immune Responses by Dietary and Microbial Metabolites

Kumar Amit,  Smith Carolyne,  Jobin Christian,  Trinchieri Giorgio,  Howcroft T. Kevin,  Seifried Harold,  Espey Michael Graham,  Flores Roberto,  Kim Young S.,  Daschner Phillip J.
JNCI-J Natl Cancer Inst 2017 Jun;109(6)
Major Program(s) or Research Group(s): Nutritional Science
PubMed ID: not available
PMC ID: not available

Bioactivity of Oral Linaclotide in Human Colorectum for Cancer Chemoprevention.

Weinberg DS,  Lin JE,  Foster NR,  Della'Zanna G,  Umar A,  Seisler D,  Kraft WK,  Kastenberg DM,  Katz LC,  Limburg PJ,  Waldman SA
Cancer Prev Res (Phila) 2017 Jun;10(6):345-354
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 28396341
PMC ID: PMC5758862

Spectral biomarkers for chemoprevention of colonic neoplasia: a placebo-controlled double-blinded trial with aspirin.

Roy HK,  Turzhitsky V,  Wali R,  Radosevich AJ,  Jovanovic B,  Della'Zanna G,  Umar A,  Rubin DT,  Goldberg MJ,  Bianchi L,  De La Cruz M,  Bogojevic A,  Helenowski IB,  Rodriguez L,  Chatterton R,  Skripkauskas S,  Page K,  Weber CR,  Huang X,  Richmond E,  Bergan RC,  Backman V
Gut 2017 Feb;66(2):285-292
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 26503631
PMC ID: PMC5108693

NSAIDs and EGFR Inhibitors for Duodenal Polyp Prevention.

Umar A,  Richmond E
JAMA Oncol 2016 Sep 1;2(9):1223-5
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 27367234
PMC ID: not available

Pancreatic Cancer Chemoprevention Translational Workshop: Meeting Report.

Miller MS,  Allen P,  Brentnall TA,  Goggins M,  Hruban RH,  Petersen GM,  Rao CV,  Whitcomb DC,  Brand RE,  Chari ST,  Klein AP,  Lubman DM,  Rhim AD,  Simeone DM,  Wolpin BM,  Umar A,  Srivastava S,  Steele VE,  Rinaudo JA
Pancreas 2016 Sep;45(8):1080-91
Major Program(s) or Research Group(s): Chemopreventive Agent DevelopmentCancer BiomarkersGastrointestinal and Other Cancers
PubMed ID: 27518363
PMC ID: PMC4988336

Zfp703 Is a Wnt/β-Catenin Feedback Suppressor Targeting the β-Catenin/Tcf1 Complex.

Kumar A,  Chalamalasetty RB,  Kennedy MW,  Thomas S,  Inala SN,  Garriock RJ,  Yamaguchi TP
Mol Cell Biol 2016 Jun 15;36(12):1793-802
Major Program(s) or Research Group(s): Nutritional Science
PubMed ID: 27090637
PMC ID: PMC4907093

Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170.

Dunning AM,  Michailidou K,  Kuchenbaecker KB,  Thompson D,  French JD,  Beesley J,  Healey CS,  Kar S,  Pooley KA,  Lopez-Knowles E,  Dicks E,  Barrowdale D,  Sinnott-Armstrong NA,  Sallari RC,  Hillman KM,  Kaufmann S,  Sivakumaran H,  Moradi Marjaneh M,  Lee JS,  Hills M,  Jarosz M,  Drury S,  Canisius S,  Bolla MK,  Dennis J,  Wang Q,  Hopper JL,  Southey MC,  Broeks A,  Schmidt MK,  Lophatananon A,  Muir K,  Beckmann MW,  Fasching PA,  Dos-Santos-Silva I,  Peto J,  Sawyer EJ,  Tomlinson I,  Burwinkel B,  Marme F,  Guénel P,  Truong T,  Bojesen SE,  Flyger H,  González-Neira A,  Perez JI,  Anton-Culver H,  Eunjung L,  Arndt V,  Brenner H,  Meindl A,  Schmutzler RK,  Brauch H,  Hamann U,  Aittomäki K,  Blomqvist C,  Ito H,  Matsuo K,  Bogdanova N,  Dörk T,  Lindblom A,  Margolin S,  Kosma VM,  Mannermaa A,  Tseng CC,  Wu AH,  Lambrechts D,  Wildiers H,  Chang-Claude J,  Rudolph A,  Peterlongo P,  Radice P,  Olson JE,  Giles GG,  Milne RL,  Haiman CA,  Henderson BE,  Goldberg MS,  Teo SH,  Yip CH,  Nord S,  Borresen-Dale AL,  Kristensen V,  Long J,  Zheng W,  Pylkäs K,  Winqvist R,  Andrulis IL,  Knight JA,  Devilee P,  Seynaeve C,  Figueroa J,  Sherman ME,  Czene K,  Darabi H,  Hollestelle A,  van den Ouweland AM,  Humphreys K,  Gao YT,  Shu XO,  Cox A,  Cross SS,  Blot W,  Cai Q,  Ghoussaini M,  Perkins BJ,  Shah M,  Choi JY,  Kang D,  Lee SC,  Hartman M,  Kabisch M,  Torres D,  Jakubowska A,  Lubinski J,  Brennan P,  Sangrajrang S,  Ambrosone CB,  Toland AE,  Shen CY,  Wu PE,  Orr N,  Swerdlow A,  McGuffog L,  Healey S,  Lee A,  Kapuscinski M,  John EM,  Terry MB,  Daly MB,  Goldgar DE,  Buys SS,  Janavicius R,  Tihomirova L,  Tung N,  Dorfling CM,  van Rensburg EJ,  Neuhausen SL,  Ejlertsen B,  Hansen TV,  Osorio A,  Benitez J,  Rando R,  Weitzel JN,  Bonanni B,  Peissel B,  Manoukian S,  Papi L,  Ottini L,  Konstantopoulou I,  Apostolou P,  Garber J,  Rashid MU,  Frost D,  EMBRACE,  Izatt L,  Ellis S,  Godwin AK,  Arnold N,  Niederacher D,  Rhiem K,  Bogdanova-Markov N,  Sagne C,  Stoppa-Lyonnet D,  Damiola F,  GEMO Study Collaborators,  Sinilnikova OM,  Mazoyer S,  Isaacs C,  Claes KB,  De Leeneer K,  de la Hoya M,  Caldes T,  Nevanlinna H,  Khan S,  Mensenkamp AR,  HEBON,  Hooning MJ,  Rookus MA,  Kwong A,  Olah E,  Diez O,  Brunet J,  Pujana MA,  Gronwald J,  Huzarski T,  Barkardottir RB,  Laframboise R,  Soucy P,  Montagna M,  Agata S,  Teixeira MR,  kConFab Investigators,  Park SK,  Lindor N,  Couch FJ,  Tischkowitz M,  Foretova L,  Vijai J,  Offit K,  Singer CF,  Rappaport C,  Phelan CM,  Greene MH,  Mai PL,  Rennert G,  Imyanitov EN,  Hulick PJ,  Phillips KA,  Piedmonte M,  Mulligan AM,  Glendon G,  Bojesen A,  Thomassen M,  Caligo MA,  Yoon SY,  Friedman E,  Laitman Y,  Borg A,  von Wachenfeldt A,  Ehrencrona H,  Rantala J,  Olopade OI,  Ganz PA,  Nussbaum RL,  Gayther SA,  Nathanson KL,  Domchek SM,  Arun BK,  Mitchell G,  Karlan BY,  Lester J,  Maskarinec G,  Woolcott C,  Scott C,  Stone J,  Apicella C,  Tamimi R,  Luben R,  Khaw KT,  Helland Å,  Haakensen V,  Dowsett M,  Pharoah PD,  Simard J,  Hall P,  García-Closas M,  Vachon C,  Chenevix-Trench G,  Antoniou AC,  Easton DF,  Edwards SL
Nat Genet 2016 Apr;48(4):374-86
PubMed ID: 26928228
PMC ID: PMC4938803

Introduction: Cancer chemoprevention and its context.

Dunn BK,  Umar A,  Richmond E
Semin Oncol 2016 Feb;43(1):19-21
Major Program(s) or Research Group(s): Chemopreventive Agent DevelopmentGastrointestinal and Other Cancers
PubMed ID: 26970121
PMC ID: PMC5166611

Mechanisms of esophageal adenocarcinoma formation and approaches to chemopreventive intervention.

Richmond E,  Umar A
Semin Oncol 2016 Feb;43(1):78-85
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 26970126
PMC ID: not available

Mechanisms of nonsteroidal anti-inflammatory drugs in cancer prevention.

Umar A,  Steele VE,  Menter DG,  Hawk ET
Semin Oncol 2016 Feb;43(1):65-77
Major Program(s) or Research Group(s): Chemopreventive Agent DevelopmentGastrointestinal and Other Cancers
PubMed ID: 26970125
PMC ID: not available

Immunologic approaches to cancer prevention-current status, challenges, and future perspectives.

Wojtowicz ME,  Dunn BK,  Umar A
Semin Oncol 2016 Feb;43(1):161-172
Major Program(s) or Research Group(s): Chemopreventive Agent DevelopmentGastrointestinal and Other CancersLung and Upper Aerodigestive Cancer
PubMed ID: 26970135
PMC ID: not available

Colorectal cancer prevention and fishful thinking.

Umar A,  Richmond E,  Kramer BS
J Natl Cancer Inst 2015 Apr;107(4)
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers ;  Office of the Director
PubMed ID: 25810493
PMC ID: not available

Estimates of benefits and harms of prophylactic use of aspirin in the general population.

Cuzick J,  Thorat MA,  Bosetti C,  Brown PH,  Burn J,  Cook NR,  Ford LG,  Jacobs EJ,  Jankowski JA,  La Vecchia C,  Law M,  Meyskens F,  Rothwell PM,  Senn HJ,  Umar A
Ann Oncol 2015 Jan;26(1):47-57
Major Program(s) or Research Group(s): Gastrointestinal and Other CancersLung and Upper Aerodigestive Cancer ;  Office of the Director
PubMed ID: 25096604
PMC ID: PMC4269341

Proteomics in Cell Culture: From Genomics to Combined 'Omics for Cell Line Engineering and Bioprocess Development

Heffner K,  Kaas CS,  Kumar A,  Baycin-Hizal D,  Betenbaugh M
2015
AlRubeai M
Animal Cell Culture
ISBN: 978-3-319-10320-4; 978-3-319-10319-8
Major Program(s) or Research Group(s): Nutritional Science

The beta-3 adrenergic agonist (CL-316,243) restores the expression of down-regulated fatty acid oxidation genes in type 2 diabetic mice.

Kumar A,  Shiloach J,  Betenbaugh MJ,  Gallagher EJ
Nutr Metab (Lond) 2015;12:8
Major Program(s) or Research Group(s): Nutritional Science
PubMed ID: 25784953
PMC ID: PMC4362840

Cancer immunoprevention: a new approach to intercept cancer early.

Umar A
Cancer Prev Res (Phila) 2014 Nov;7(11):1067-71
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 25237055
PMC ID: not available

Barrett's Esophagus Translational Research Network (BETRNet): the pivotal role of multi-institutional collaboration in esophageal adenocarcinoma research.

Abrams JA,  Appelman HD,  Beer DG,  Berry LD,  Chak A,  Falk GW,  Fitzgerald RC,  Ginsberg GG,  Grady WM,  Joshi BP,  Lynch JP,  Markowitz S,  Richmond ES,  Rustgi AK,  Seibel EJ,  Shaheen NJ,  Shyr Y,  Umar A,  Wang KK,  Wang TC,  Wang TD,  Yassin R
Gastroenterology 2014 Jun;146(7):1586-90
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 24768332
PMC ID: PMC4224108

Pleiotropic effects of genetic risk variants for other cancers on colorectal cancer risk: PAGE, GECCO and CCFR consortia.

Cheng I,  Kocarnik JM,  Dumitrescu L,  Lindor NM,  Chang-Claude J,  Avery CL,  Caberto CP,  Love SA,  Slattery ML,  Chan AT,  Baron JA,  Hindorff LA,  Park SL,  Schumacher FR,  Hoffmeister M,  Kraft P,  Butler AM,  Duggan DJ,  Hou L,  Carlson CS,  Monroe KR,  Lin Y,  Carty CL,  Mann S,  Ma J,  Giovannucci EL,  Fuchs CS,  Newcomb PA,  Jenkins MA,  Hopper JL,  Haile RW,  Conti DV,  Campbell PT,  Potter JD,  Caan BJ,  Schoen RE,  Hayes RB,  Chanock SJ,  Berndt SI,  Küry S,  Bézieau S,  Ambite JL,  Kumaraguruparan G,  Richardson DM,  Goodloe RJ,  Dilks HH,  Baker P,  Zanke BW,  Lemire M,  Gallinger S,  Hsu L,  Jiao S,  Harrison TA,  Seminara D,  Haiman CA,  Kooperberg C,  Wilkens LR,  Hutter CM,  White E,  Crawford DC,  Heiss G,  Hudson TJ,  Brenner H,  Bush WS,  Casey G,  Le Marchand L,  Peters U
Gut 2014 May;63(5):800-7
Major Program(s) or Research Group(s): Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
PubMed ID: 23935004
PMC ID: PMC3918490

Future directions in cancer prevention.

Umar A,  Dunn BK,  Greenwald P
Nat Rev Cancer 2012 Dec;12(12):835-48
Major Program(s) or Research Group(s): Chemopreventive Agent Development
PubMed ID: 23151603
PMC ID: not available

Is 15-LOX-1 a tumor suppressor?

Umar A
J Natl Cancer Inst 2012 May 2;104(9):645-7
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 22472307
PMC ID: not available

Barrett's esophagus: natural history.

Appelman HD,  Umar A,  Orlando RC,  Sontag SJ,  Nandurkar S,  El-Zimaity H,  Lanas A,  Parise P,  Lambert R,  Shields HM
Ann N Y Acad Sci 2011 Sep;1232:292-308
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 21950819
PMC ID: not available

Chemoprevention of nonmelanoma skin cancer with celecoxib: a randomized, double-blind, placebo-controlled trial.

Elmets CA,  Viner JL,  Pentland AP,  Cantrell W,  Lin HY,  Bailey H,  Kang S,  Linden KG,  Heffernan M,  Duvic M,  Richmond E,  Elewski BE,  Umar A,  Bell W,  Gordon GB
J Natl Cancer Inst 2010 Dec 15;102(24):1835-44
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 21115882
PMC ID: PMC3001966

Further thoughts on preclinical animal models for cancer prevention: when is it best to start treatment? What are potential histopathologic endpoints?

Umar A,  Della'Zanna G,  Lubet R
Semin Oncol 2010 Aug;37(4):339-44
Major Program(s) or Research Group(s): Gastrointestinal and Other CancersChemopreventive Agent Development
PubMed ID: 20816504
PMC ID: not available

One year recurrence of aberrant crypt foci.

Pinsky PF,  Fleshman J,  Mutch M,  Rall C,  Charabaty A,  Seligson D,  Dry S,  Umar A,  Schoen RE
Cancer Prev Res (Phila) 2010 Jul;3(7):839-43
Major Program(s) or Research Group(s): Gastrointestinal and Other CancersEarly DetectionProstate, Lung, Colorectal, and Ovarian Cancer Screening Trial
PubMed ID: 20570885
PMC ID: PMC2900400

Alarming colorectal cancer incidence trends: a case for early detection and prevention.

Umar A,  Greenwald P
Cancer Epidemiol Biomarkers Prev 2009 Jun;18(6):1672-3
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 19505897
PMC ID: not available

A multicenter study of prevalence and risk factors for aberrant crypt foci.

Mutch MG,  Schoen RE,  Fleshman JW,  Rall CJ,  Dry S,  Seligson D,  Charabaty A,  Chia D,  Umar A,  Viner J,  Hawk E,  Pinsky PF
Clin Gastroenterol Hepatol 2009 May;7(5):568-74
Major Program(s) or Research Group(s): Gastrointestinal and Other CancersEarly DetectionProstate, Lung, Colorectal, and Ovarian Cancer Screening Trial
PubMed ID: 19418605
PMC ID: not available

Five-year efficacy and safety analysis of the Adenoma Prevention with Celecoxib Trial.

Bertagnolli MM,  Eagle CJ,  Zauber AG,  Redston M,  Breazna A,  Kim K,  Tang J,  Rosenstein RB,  Umar A,  Bagheri D,  Collins NT,  Burn J,  Chung DC,  Dewar T,  Foley TR,  Hoffman N,  Macrae F,  Pruitt RE,  Saltzman JR,  Salzberg B,  Sylwestrowicz T,  Hawk ET,  Adenoma Prevention with Celecoxib Study Investigators
Cancer Prev Res (Phila) 2009 Apr;2(4):310-21
Major Program(s) or Research Group(s): Gastrointestinal and Other CancersBiometry
PubMed ID: 19336730
PMC ID: PMC2976587

Combination targeted therapy with sorafenib and bevacizumab results in enhanced toxicity and antitumor activity.

Azad NS,  Posadas EM,  Kwitkowski VE,  Steinberg SM,  Jain L,  Annunziata CM,  Minasian L,  Sarosy G,  Kotz HL,  Premkumar A,  Cao L,  McNally D,  Chow C,  Chen HX,  Wright JJ,  Figg WD,  Kohn EC
J Clin Oncol 2008 Aug 1;26(22):3709-14
Major Program(s) or Research Group(s): Office of the Director
PubMed ID: 18669456
PMC ID: not available

Introduction: diet, epigenetic events and cancer prevention.

Ross SA,  Dwyer J,  Umar A,  Kagan J,  Verma M,  Van Bemmel DM,  Dunn BK
Nutr Rev 2008 Aug;66 Suppl 1:S1-6
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 18673478
PMC ID: PMC2547124

The natural history of aberrant crypt foci.

Schoen RE,  Mutch M,  Rall C,  Dry SM,  Seligson D,  Umar A,  Pinsky P
Gastrointest Endosc 2008 Jun;67(7):1097-102
Major Program(s) or Research Group(s): Early DetectionProstate, Lung, Colorectal, and Ovarian Cancer Screening Trial
PubMed ID: 18178205
PMC ID: not available

Lack of reliability of CA125 response criteria with anti-VEGF molecularly targeted therapy.

Azad NS,  Annunziata CM,  Steinberg SM,  Minasian L,  Premkumar A,  Chow C,  Kotz HL,  Kohn EC
Cancer 2008 Apr 15;112(8):1726-32
Major Program(s) or Research Group(s): Office of the Director
PubMed ID: 18300236
PMC ID: not available

A prospective analysis of imatinib-induced c-KIT modulation in ovarian cancer: a phase II clinical study with proteomic profiling.

Posadas EM,  Kwitkowski V,  Kotz HL,  Espina V,  Minasian L,  Tchabo N,  Premkumar A,  Hussain MM,  Chang R,  Steinberg SM,  Kohn EC
Cancer 2007 Jul 15;110(2):309-17
Major Program(s) or Research Group(s): Office of the Director
PubMed ID: 17559139
PMC ID: not available

Colorectal Cancer Prevention: Diet, Drugs, or Nothing

Umar A,  Richmond E,  Griebel DJ
Current Colorectal Cancer Reports 2007;3(1):16-23
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: not available
PMC ID: not available

Gene expression analysis of tumor infiltrating lymphocyte markers in endometrial cancers indicates no significant increases in those cases with microsatellite instability.

Risinger JI,  Chandramouli GV,  Maxwell GL,  Litzi T,  Berchuck A,  Umar A
Cancer Biomark 2006;2(1-2):61-8
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 17192060
PMC ID: not available

NCI Committed to Colorectal Cancer Prevention.

Umar A
Guest Update for Director's Update NCI Cancer Bulletin 2006;3(34):1-2
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: not available
PMC ID: not available

Lynch syndrome (HNPCC) and microsatellite instability analysis guidelines.

Umar A,  International Workshop on Diagnostic Guidelines for Hereditary Non-Polyposis Colorectal Cancer and Microsatellite Instability
Cancer Biomark 2006;2(1-2):1-4
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 17192054
PMC ID: not available

Gene expression profiling of microsatellite unstable and microsatellite stable endometrial cancers indicates distinct pathways of aberrant signaling.

Risinger JI,  Maxwell GL,  Chandramouli GV,  Aprelikova O,  Litzi T,  Umar A,  Berchuck A,  Barrett JC
Cancer Res 2005 Jun 15;65(12):5031-7
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 15958545
PMC ID: not available

Prevention and therapy of colorectal cancer.

Hawk ET,  Umar A,  Richmond E,  Viner JL
Med Clin North Am 2005 Jan;89(1):85-110, viii
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 15527810
PMC ID: not available

Functional analysis of a novel androgen receptor mutation, Q902K, in an individual with partial androgen insensitivity.

Umar A,  Berrevoets CA,  Van NM,  van Leeuwen M,  Verbiest M,  Kleijer WJ,  Dooijes D,  Grootegoed JA,  Drop SL,  Brinkmann AO
J Clin Endocrinol Metab 2005 Jan;90(1):507-15
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 15486055
PMC ID: not available

Can animal models help us select specific compounds for cancer prevention trials?

Hawk ET,  Umar A,  Lubet RA,  Kopelovich L,  Viner JL
Recent Results Cancer Res 2005;166:71-87
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 15648184
PMC ID: not available

Modulation by celecoxib and difluoromethylornithine of the methylation of DNA and the estrogen receptor-alpha gene in rat colon tumors.

Pereira MA,  Tao L,  Wang W,  Li Y,  Umar A,  Steele VE,  Lubet RA
Carcinogenesis 2004 Oct;25(10):1917-23
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 15205357
PMC ID: not available

Interactions between aspirin and COX-2 inhibitors or NSAIDs in a rat thrombosis model.

Umar A,  Boisseau M,  Yusup A,  Upur H,  Bégaud B,  Moore N
Fundam Clin Pharmacol 2004 Oct;18(5):559-63
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 15482377
PMC ID: not available

Colorectal cancer chemoprevention--an overview of the science.

Hawk ET,  Umar A,  Viner JL
Gastroenterology 2004 May;126(5):1423-47
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 15131803
PMC ID: not available

Proceedings: the Applications of Bioinformatics in Cancer Detection Workshop.

Kapetanovic IM,  Umar A,  Khan J
Ann N Y Acad Sci 2004 May;1020:1-9
Major Program(s) or Research Group(s): Gastrointestinal and Other CancersChemopreventive Agent Development
PubMed ID: 15208178
PMC ID: not available

Applications of bioinformatics in cancer detection: a lexicon of bioinformatics terms.

Umar A
Ann N Y Acad Sci 2004 May;1020:263-76
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 15208197
PMC ID: not available

Serum proteomic profiles suggest celecoxib-modulated targets and response predictors.

Xiao Z,  Luke BT,  Izmirlian G,  Umar A,  Lynch PM,  Phillips RK,  Patterson S,  Conrads TP,  Veenstra TD,  Greenwald P,  Hawk ET,  Ali IU
Cancer Res 2004 Apr 15;64(8):2904-9
Major Program(s) or Research Group(s): Gastrointestinal and Other CancersBiometry
PubMed ID: 15087410
PMC ID: not available

Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability.

Umar A,  Boland CR,  Terdiman JP,  Syngal S,  de la Chapelle A,  Rüschoff J,  Fishel R,  Lindor NM,  Burgart LJ,  Hamelin R,  Hamilton SR,  Hiatt RA,  Jass J,  Lindblom A,  Lynch HT,  Peltomaki P,  Ramsey SD,  Rodriguez-Bigas MA,  Vasen HF,  Hawk ET,  Barrett JC,  Freedman AN,  Srivastava S
J Natl Cancer Inst 2004 Feb 18;96(4):261-8
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 14970275
PMC ID: PMC2933058

Testing guidelines for hereditary non-polyposis colorectal cancer.

Umar A,  Risinger JI,  Hawk ET,  Barrett JC
Nat Rev Cancer 2004 Feb;4(2):153-8
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 14964310
PMC ID: not available

An Msh2 point mutation uncouples DNA mismatch repair and apoptosis.

Lin DP,  Wang Y,  Scherer SJ,  Clark AB,  Yang K,  Avdievich E,  Jin B,  Werling U,  Parris T,  Kurihara N,  Umar A,  Kucherlapati R,  Lipkin M,  Kunkel TA,  Edelmann W
Cancer Res 2004 Jan 15;64(2):517-22
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 14744764
PMC ID: not available

Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors.

Lu Q,  Yang YT,  Chen CS,  Davis M,  Byrd JC,  Etherton MR,  Umar A,  Chen CS
J Med Chem 2004 Jan 15;47(2):467-74
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 14711316
PMC ID: not available

Nutrition and cancer prevention: a multidisciplinary perspective on human trials.

Forman MR,  Hursting SD,  Umar A,  Barrett JC
Annu Rev Nutr 2004;24:223-54
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 15189120
PMC ID: not available

Lynch syndrome (HNPCC) and microsatellite instability.

Umar A
Dis Markers 2004;20(4-5):179-80
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 15528783
PMC ID: PMC3839338

The promise of biomarkers in colorectal cancer detection.

Umar A,  Srivastava S
Dis Markers 2004;20(2):87-96
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 15322316
PMC ID: PMC3839323

Phase II trial of carboxyamidotriazole in patients with relapsed epithelial ovarian cancer.

Hussain MM,  Kotz H,  Minasian L,  Premkumar A,  Sarosy G,  Reed E,  Zhai S,  Steinberg SM,  Raggio M,  Oliver VK,  Figg WD,  Kohn EC
J Clin Oncol 2003 Dec 1;21(23):4356-63
Major Program(s) or Research Group(s): Office of the Director
PubMed ID: 14645425
PMC ID: not available

Cyclooxygenase inhibition in cancer prevention and treatment.

Anderson WF,  Umar A,  Hawk ET
Expert Opin Pharmacother 2003 Dec;4(12):2193-204
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 14640918
PMC ID: not available

Development of COX inhibitors in cancer prevention and therapy.

Umar A,  Viner JL,  Anderson WF,  Hawk ET
Am J Clin Oncol 2003 Aug;26(4):S48-57
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 12902856
PMC ID: not available

Colorectal carcinoma in black and white race.

Anderson WF,  Umar A,  Brawley OW
Cancer Metastasis Rev 2003 Mar;22(1):67-82
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 12716038
PMC ID: not available

Epigenetics in cancer prevention: early detection and risk assessment: introduction.

Dunn BK,  Verma M,  Umar A
Ann N Y Acad Sci 2003 Mar;983:1-4
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 12724207
PMC ID: not available

DNA methylation as a cancer-specific biomarker: from molecules to populations.

Patel A,  Groopman JD,  Umar A
Ann N Y Acad Sci 2003 Mar;983:286-97
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 12724233
PMC ID: not available

Early detection and risk assessment: proceedings and recommendations from the Workshop on Epigenetics in Cancer Prevention.

Verma M,  Dunn BK,  Ross S,  Jain P,  Wang W,  Hayes R,  Umar A
Ann N Y Acad Sci 2003 Mar;983:298-319
Major Program(s) or Research Group(s): Gastrointestinal and Other CancersCancer BiomarkersNutritional Science
PubMed ID: 12724234
PMC ID: not available

Cancer and the cyclooxygenase enzyme - Implications for prevention and treatment.

Hawk E,  Viner JL,  Umar A,  Anderson WF,  Sigman C,  Guyton KZ
Amer J Ca 2003;2:27-55
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: not available
PMC ID: not available

Non-steroidal anti-inflammatory drugs (NSAIDs) for colorectal cancer prevention.

Hawk ET,  Viner J,  Richmond E,  Umar A
Cancer Chemother Biol Response Modif 2003;21:759-89
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 15338773
PMC ID: not available

Non-steroidal anti-inflammatory and cyclooxygenase-2-selective inhibitors in clinical cancer prevention trials.

Hawk ET,  Viner JL,  Umar A
Prog Exp Tumor Res 2003;37:210-42
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 12795057
PMC ID: not available

Chemoprevention of colorectal cancer: problems, progress, and prospects.

Viner JL,  Umar A,  Hawk ET
Gastroenterol Clin North Am 2002 Dec;31(4):971-99
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 12489273
PMC ID: not available

Chemoprevention of colorectal carcinogenesis.

Umar A,  Viner JL,  Richmond E,  Anderson WF,  Hawk ET
Int J Clin Oncol 2002 Feb;7(1):2-26
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 11942045
PMC ID: not available

The role of cyclooxygenase inhibitors in cancer prevention.

Anderson WF,  Umar A,  Viner JL,  Hawk ET
Curr Pharm Des 2002;8(12):1035-62
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 11945150
PMC ID: not available

The future of colon cancer prevention.

Umar A,  Viner JL,  Hawk ET
Ann N Y Acad Sci 2001 Dec;952:88-108
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 11795446
PMC ID: not available

Complementation of an hMSH2 defect in human colorectal carcinoma cells by human chromosome 2 transfer.

Watanabe Y,  Haugen-Strano A,  Umar A,  Yamada K,  Hemmi H,  Kikuchi Y,  Takano S,  Shibata Y,  Barrett JC,  Kunkel TA,  Koi M
Mol Carcinog 2000 Sep;29(1):37-49
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 11020245
PMC ID: not available

The DNA mismatch repair genes Msh3 and Msh6 cooperate in intestinal tumor suppression.

Edelmann W,  Umar A,  Yang K,  Heyer J,  Kucherlapati M,  Lia M,  Kneitz B,  Avdievich E,  Fan K,  Wong E,  Crouse G,  Kunkel T,  Lipkin M,  Kolodner RD,  Kucherlapati R
Cancer Res 2000 Feb 15;60(4):803-7
Major Program(s) or Research Group(s): Gastrointestinal and Other Cancers
PubMed ID: 10706084
PMC ID: not available