Publication Results

Generate Report

Add publications by marking their checkboxes, or

Durvalumab in Combination with Olaparib in Patients with Relapsed SCLC: Results from a Phase II Study.

Thomas A,  Vilimas R,  Trindade C,  Erwin-Cohen R,  Roper N,  Xi L,  Krishnasamy V,  Levy E,  Mammen A,  Nichols S,  Chen Y,  Velcheti V,  Yin F,  Szabo E,  Pommier Y,  Steinberg SM,  Trepel JB,  Raffeld M,  Young HA,  Khan J,  Hewitt S,  Lee JM
J Thorac Oncol 2019 Aug;14(8):1447-1457
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 31063862
PMC ID: PMC6660419

Potential Influence on Clinical Trials of Long-Term Survivors of Stage IV Non-small cell Lung Cancer.

Davis JS,  Prophet E,  Peng HL,  Lee HY,  Tidwell RSS,  Lee JJ,  Thomas A,  Szabo E,  Chang S
JNCI Cancer Spectr 2019 Jun;3(2):pkz010
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 31218274
PMC ID: PMC6563418

A phase I/II study of pemetrexed with sirolimus in advanced, previously treated non-small cell lung cancer.

Komiya T,  Memmott RM,  Blumenthal GM,  Bernstein W,  Ballas MS,  De Chowdhury R,  Chun G,  Peer CJ,  Figg WD,  Liewehr DJ,  Steinberg SM,  Giaccone G,  Szabo E,  Kawabata S,  Tsurutani J,  Rajan A,  Dennis PA
Transl Lung Cancer Res 2019 Jun;8(3):247-257
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 31367538
PMC ID: PMC6626857

A prospective, single-arm, open-label, non-randomized, phase IIa trial of a nonavalent prophylactic HPV vaccine to assess immunogenicity of a prime and deferred-booster dosing schedule among 9-11 year-old girls and boys - clinical protocol.

Zeng Y,  Moscicki AB,  Sahasrabuddhe VV,  Garcia F,  Woo H,  Hsu CH,  Szabo E,  Dimond E,  Vanzzini S,  Mondragon A,  Butler V,  DeRose H,  Chow HS
BMC Cancer 2019 Apr 1;19(1):290
Major Program(s) or Research Group(s): Breast and Gynecologic CancerLung and Upper Aerodigestive Cancer
PubMed ID: 30935375
PMC ID: PMC6444524

Acceptability of Localized Cancer Risk Reduction Interventions Among Individuals at Average or High Risk for Cancer.

Samimi G,  Heckman-Stoddard BM,  Kay SS,  Bloodgood B,  Coa KI,  Robinson JL,  Tennant B,  Ford LG,  Szabo E,  Minasian L
Cancer Prev Res (Phila) 2019 Apr;12(4):271-282
Major Program(s) or Research Group(s): Breast and Gynecologic CancerLung and Upper Aerodigestive Cancer ;  Office of the Director
PubMed ID: 30824471
PMC ID: PMC6445710

Inhibition of mTOR Signaling and Clinical Activity of Rapamycin in Head and Neck Cancer in a Window of Opportunity Trial.

Day TA,  Shirai K,  O'Brien PE,  Matheus MG,  Godwin K,  Sood AJ,  Kompelli A,  Vick JA,  Martin D,  Vitale-Cross L,  Callejas-Varela JL,  Wang Z,  Wu X,  Harismendy O,  Molinolo AA,  Lippman SM,  Van Waes C,  Szabo E,  Gutkind JS
Clin Cancer Res 2019 Feb 15;25(4):1156-1164
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 30420444
PMC ID: PMC6377824

AACR White Paper: Shaping the Future of Cancer Prevention - A Roadmap for Advancing Science and Public Health.

Lippman SM,  Abate-Shen C,  Colbert Maresso KL,  Colditz GA,  Dannenberg AJ,  Davidson NE,  Disis ML,  DuBois RN,  Szabo E,  Giuliano AR,  Hait WN,  Lee JJ,  Kensler TW,  Kramer BS,  Limburg P,  Maitra A,  Martinez ME,  Rebbeck TR,  Schmitz KH,  Vilar E,  Hawk ET
Cancer Prev Res (Phila) 2018 Dec;11(12):735-778
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 30530635
PMC ID: not available

Characteristics and Outcomes of Small Cell Lung Cancer Detected by CT Screening.

Thomas A,  Pattanayak P,  Szabo E,  Pinsky P
Chest 2018 Dec;154(6):1284-1290
Major Program(s) or Research Group(s): Early DetectionLung and Upper Aerodigestive Cancer
PubMed ID: 30080997
PMC ID: PMC6335258

Airway brushing as a new experimental methodology to detect airway gene expression signatures in mouse lung squamous cell carcinoma.

Pan J,  Xiong D,  Zhang Q,  Szabo E,  Miller MS,  Lubet RA,  Wang Y,  You M
Sci Rep 2018 Jun 11;8(1):8895
Major Program(s) or Research Group(s): Chemopreventive Agent DevelopmentLung and Upper Aerodigestive Cancer
PubMed ID: 29891994
PMC ID: PMC5995924

Phase I Study of ATR Inhibitor M6620 in Combination With Topotecan in Patients With Advanced Solid Tumors.

Thomas A,  Redon CE,  Sciuto L,  Padiernos E,  Ji J,  Lee MJ,  Yuno A,  Lee S,  Zhang Y,  Tran L,  Yutzy W,  Rajan A,  Guha U,  Chen H,  Hassan R,  Alewine CC,  Szabo E,  Bates SE,  Kinders RJ,  Steinberg SM,  Doroshow JH,  Aladjem MI,  Trepel JB,  Pommier Y
J Clin Oncol 2018 Jun 1;36(16):1594-1602
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 29252124
PMC ID: PMC5978471

Reduced IL-6 levels and tumor-associated phospho-STAT3 are associated with reduced tumor development in a mouse model of lung cancer chemoprevention with myo-inositol.

Unver N,  Delgado O,  Zeleke K,  Cumpian A,  Tang X,  Caetano MS,  Wang H,  Katayama H,  Yu H,  Szabo E,  Wistuba II,  Moghaddam SJ,  Hanash SM,  Ostrin EJ
Int J Cancer 2018 Apr 1;142(7):1405-1417
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 29134640
PMC ID: PMC5805587

Novel mutational landscapes and expression signatures of lung squamous cell carcinoma.

Xiong D,  Pan J,  Yin Y,  Jiang H,  Szabo E,  Lubet RA,  Wang Y,  You M
Oncotarget 2018 Jan 26;9(7):7424-7441
Major Program(s) or Research Group(s): Chemopreventive Agent DevelopmentLung and Upper Aerodigestive Cancer
PubMed ID: 29484121
PMC ID: PMC5800913

Effect of weekly or daily dosing regimen of Gefitinib in mouse models of lung cancer.

Zhang Q,  Li R,  Chen X,  Lee SB,  Pan J,  Xiong D,  Hu J,  Miller MS,  Szabo E,  Lubet RA,  Wang Y,  You M
Oncotarget 2017 Sep 22;8(42):72447-72456
Major Program(s) or Research Group(s): Chemopreventive Agent DevelopmentLung and Upper Aerodigestive Cancer
PubMed ID: 29069801
PMC ID: PMC5641144

Pioglitazone-mediated reversal of elevated glucose metabolism in the airway epithelium of mouse lung adenocarcinomas.

Xiong D,  Pan J,  Zhang Q,  Szabo E,  Miller MS,  Lubet RA,  Wang Y,  You M
JCI Insight 2017 Jul 6;2(13)
Major Program(s) or Research Group(s): Chemopreventive Agent DevelopmentLung and Upper Aerodigestive Cancer
PubMed ID: 28679956
PMC ID: PMC5499364

Cancer prevention in the era of precision oncology.

Brahme NN,  Szabo E
Clin Pharmacol Ther 2017 May;101(5):575-577
Major Program(s) or Research Group(s): Cancer Prevention Fellowship ProgramLung and Upper Aerodigestive Cancer
PubMed ID: 28032900
PMC ID: not available

Hepatoid adenocarcinoma of the lung metastasizing to the tonsil.

Valle L,  Thomas J,  Kim C,  Szabo E,  Brown GT,  Citrin D,  Rajan A
Mol Clin Oncol 2017 May;6(5):705-707
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 28529745
PMC ID: PMC5431682

Bronchial airway gene expression signatures in mouse lung squamous cell carcinoma and their modulation by cancer chemopreventive agents.

Xiong D,  Pan J,  Zhang Q,  Szabo E,  Miller MS,  Lubet RA,  You M,  Wang Y
Oncotarget 2017 Mar 21;8(12):18885-18900
Major Program(s) or Research Group(s): Chemopreventive Agent DevelopmentLung and Upper Aerodigestive Cancer
PubMed ID: 27935865
PMC ID: PMC5386655

Consolidative local therapy in oligometastatic patients.

Kim C,  Szabo E,  Guha U,  Rajan A
Lancet Oncol 2017 Feb;18(2):e61
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 28214415
PMC ID: not available

A Randomized Phase IIb Trial of myo-Inositol in Smokers with Bronchial Dysplasia.

Lam S,  Mandrekar SJ,  Gesthalter Y,  Allen Ziegler KL,  Seisler DK,  Midthun DE,  Mao JT,  Aubry MC,  McWilliams A,  Sin DD,  Shaipanich T,  Liu G,  Johnson E,  Bild A,  Lenburg ME,  Ionescu DN,  Mayo J,  Yi JE,  Tazelaar H,  Harmsen WS,  Smith J,  Spira AE,  Beane J,  Limburg PJ,  Szabo E,  Cancer Prevention Network
Cancer Prev Res (Phila) 2016 Dec;9(12):906-914
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 27658890
PMC ID: PMC5136333

Correlation analysis of oral lesion sizes by various standardized criteria.

Flanagan CE,  Rhodus NL,  Cole KA,  Szabo E,  Ondrey FG
Am J Otolaryngol 2016 Nov-Dec;37(6):502-506
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 27968958
PMC ID: PMC5161039

Cognitive testing of tobacco use items for administration to patients with cancer and cancer survivors in clinical research.

Land SR,  Warren GW,  Crafts JL,  Hatsukami DK,  Ostroff JS,  Willis GB,  Chollette VY,  Mitchell SA,  Folz JN,  Gulley JL,  Szabo E,  Brandon TH,  Duffy SA,  Toll BA
Cancer 2016 Jun 1;122(11):1728-34
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 27019325
PMC ID: PMC5523930

Selumetinib with and without erlotinib in KRAS mutant and KRAS wild-type advanced nonsmall-cell lung cancer.

Carter CA,  Rajan A,  Keen C,  Szabo E,  Khozin S,  Thomas A,  Brzezniak C,  Guha U,  Doyle LA,  Steinberg SM,  Xi L,  Raffeld M,  Tomita Y,  Lee MJ,  Lee S,  Trepel JB,  Reckamp KL,  Koehler S,  Gitlitz B,  Salgia R,  Gandara D,  Vokes E,  Giaccone G
Ann Oncol 2016 Apr;27(4):693-9
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 26802155
PMC ID: PMC4803455

Repurposing old drugs to chemoprevention: the case of metformin.

Heckman-Stoddard BM,  Gandini S,  Puntoni M,  Dunn BK,  DeCensi A,  Szabo E
Semin Oncol 2016 Feb;43(1):123-133
Major Program(s) or Research Group(s): Breast and Gynecologic CancerChemopreventive Agent DevelopmentLung and Upper Aerodigestive Cancer
PubMed ID: 26970131
PMC ID: PMC4789107

Transforming Cancer Prevention through Precision Medicine and Immune-oncology.

Kensler TW,  Spira A,  Garber JE,  Szabo E,  Lee JJ,  Dong Z,  Dannenberg AJ,  Hait WN,  Blackburn E,  Davidson NE,  Foti M,  Lippman SM
Cancer Prev Res (Phila) 2016 Jan;9(1):2-10
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 26744449
PMC ID: PMC4955753

Repurposing Drugs for Cancer Prevention.

Lee DK,  Szabo E
Curr Top Med Chem 2016;16(19):2169-78
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 26881711
PMC ID: not available

Preinvasive Endobronchial Lesions: Lung Cancer Precursors and Risk Markers?

Lam S,  Szabo E
Am J Respir Crit Care Med 2015 Dec 15;192(12):1411-3
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 26669471
PMC ID: PMC4731725

AACR Cancer Progress Report 2015.

Baselga J,  Bhardwaj N,  Cantley LC,  DeMatteo R,  DuBois RN,  Foti M,  Gapstur SM,  Hahn WC,  Helman LJ,  Jensen RA,  Paskett ED,  Lawrence TS,  Lutzker SG,  Szabo E
Clin Cancer Res 2015 Oct 1;21(19 Suppl):S1-128
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 26429991
PMC ID: PMC5001568

A Randomized Phase IIb Trial of Myo-Inositol in Smokers with Bronchial Dysplasia

Lam Stephen,  Mandrekar Sumithra,  Ziegler Katie Allen,  Seisler Drew,  Midthun David,  Mao Jenny,  Aubry Marie Christine,  McWilliams Annette,  Sin Don,  Shaipanich Tawimas,  Spira Avrum,  Ionescu Diana,  Mayo John,  Yi Joanne Eunhee,  Tazelaar Henry,  Harmsen William,  Smith Judith,  Limburg Paul,  Szabo Eva
J Thorac Oncol 2015 Sep;10(9, Suppl 2):S218, Abstract ORAL23.01
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: not available
PMC ID: not available

Molecular cancer prevention: Current status and future directions.

Maresso KC,  Tsai KY,  Brown PH,  Szabo E,  Lippman S,  Hawk ET
CA Cancer J Clin 2015 Sep-Oct;65(5):345-83
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 26284997
PMC ID: PMC4820069

Chemoprevention Clinical Trials: How Do We Move Forward? How Do We Identify Valid End Points?

Szabo Eva
J Thorac Oncol 2015 Sep;10(9, Suppl 2):S113-S113
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: not available
PMC ID: not available

Screening for Small Cell Lung Cancer: Analysis of the National Lung Cancer Screening Trial Data

Thomas Anish,  Szabo Eva,  Pinsky Paul
J Thorac Oncol 2015 Sep;10(9, Suppl 2):S221, Abstract ORAL25.01
Major Program(s) or Research Group(s): Early DetectionLung and Upper Aerodigestive Cancer
PubMed ID: not available
PMC ID: not available

Implications of the "Bad Luck" Explanation of Cancer Risk for the Field of Cancer Prevention.

Wang TC,  Szabo E
Cancer Prev Res (Phila) 2015 Sep;8(9):761
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 26174321
PMC ID: not available

Chemoprevention Trials: Past, Present, and Future

Wigle Dennis,  Szabo Eva,  Spira Avrum
J Thorac Oncol 2015 Sep;10(9, Suppl 2):S151, Abstract MTE18.01
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: not available
PMC ID: not available

Framework for clinical evaluation of chemopreventive agents: Defining criteria for future assessment

Walsh Naomi,  Alberts David S.,  Brown Powel,  Limburg Paul,  Sherman Mark,  Szabo Eva
Cancer Res 2015 Aug 1;75(Suppl 15):Abstract 4662
Major Program(s) or Research Group(s): Breast and Gynecologic CancerLung and Upper Aerodigestive Cancer
PubMed ID: not available
PMC ID: not available

Standardizing measurement of tobacco use in cancer clinical trials

Land Stephanie R.,  Warren Graham Walter,  Moinpour Carol,  Ostroff Jamie S.,  Crafts Jennifer,  Folz Jasmine,  Gulley James L.,  Szabo Eva,  Chollette Veronica,  Brandon Thomas H.,  Duffy Sonia,  Hatsukami Dorothy K.,  Dresler Carolyn M.,  Gritz Ellen R.,  Schnoll Robert,  Sarna Linda,  Rigotti Nancy,  Buckner Jan C.,  Mitchell Sandra A.,  Toll Benjamin
J Clin Oncol 2015 May 20;33(15):Abstract e17658
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: not available
PMC ID: not available

A pilot, single arm, prospective trial using neoadjuvant rapamycin prior to definitive therapy in head and neck squamous cell carcinoma

Shirai Keisuke,  Day Terry A.,  Szabo Eva,  Van Waes Carter,  O'Brien Paul E.,  Matheus Maria Gisele,  Godwin Kristina,  Sood Amit J.,  Vick Julie A.,  Martin Daniel,  Vitale-Cross Lynn,  Molinolo Alfredo,  Gutkind Jorge Silvio
J Clin Oncol 2015 May 20;33(15):Abstract 6071
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: not available
PMC ID: not available

Long-term effects of inhaled budesonide on screening-detected lung nodules.

Veronesi G,  Lazzeroni M,  Szabo E,  Brown PH,  DeCensi A,  Guerrieri-Gonzaga A,  Bellomi M,  Radice D,  Grimaldi MC,  Spaggiari L,  Bonanni B
Ann Oncol 2015 May;26(5):1025-30
Major Program(s) or Research Group(s): Phase 0/I/II Cancer Prevention Clinical Trials ProgramLung and Upper Aerodigestive Cancer
PubMed ID: 25672894
PMC ID: PMC4405280

Molecular profiling and targeted therapy for advanced thoracic malignancies: a biomarker-derived, multiarm, multihistology phase II basket trial.

Lopez-Chavez A,  Thomas A,  Rajan A,  Raffeld M,  Morrow B,  Kelly R,  Carter CA,  Guha U,  Killian K,  Lau CC,  Abdullaev Z,  Xi L,  Pack S,  Meltzer PS,  Corless CL,  Sandler A,  Beadling C,  Warrick A,  Liewehr DJ,  Steinberg SM,  Berman A,  Doyle A,  Szabo E,  Wang Y,  Giaccone G
J Clin Oncol 2015 Mar 20;33(9):1000-7
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 25667274
PMC ID: PMC4356709

A phase IIa randomized, double-blind trial of erlotinib in inhibiting epidermal growth factor receptor signaling in aberrant crypt foci of the colorectum.

Gillen DL,  Meyskens FL,  Morgan TR,  Zell JA,  Carroll R,  Benya R,  Chen WP,  Mo A,  Tucker C,  Bhattacharya A,  Huang Z,  Arcilla M,  Wong V,  Chung J,  Gonzalez R,  Rodriguez LM,  Szabo E,  Rosenberg DW,  Lipkin SM
Cancer Prev Res (Phila) 2015 Mar;8(3):222-30
Major Program(s) or Research Group(s): Gastrointestinal and Other CancersLung and Upper Aerodigestive Cancer
PubMed ID: 25604134
PMC ID: PMC4355051

Sunitinib in patients with chemotherapy-refractory thymoma and thymic carcinoma: an open-label phase 2 trial.

Thomas A,  Rajan A,  Berman A,  Tomita Y,  Brzezniak C,  Lee MJ,  Lee S,  Ling A,  Spittler AJ,  Carter CA,  Guha U,  Wang Y,  Szabo E,  Meltzer P,  Steinberg SM,  Trepel JB,  Loehrer PJ,  Giaccone G
Lancet Oncol 2015 Feb;16(2):177-86
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 25592632
PMC ID: PMC4401497

Dermatomyositis paraneoplastic syndrome before symptomatic tonsillar squamous cell carcinoma: a case report.

Adi AH,  Alturkmani H,  Spock T,  Williams Yohannes P,  Wargo S,  Szabo E,  Gutkind JS,  Van Waes C
Head Neck 2015 Jan;37(1):E1-3
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 24715579
PMC ID: not available

Biomarkers in phase I-II chemoprevention trials: lessons from the NCI experience.

Szabo E
Ecancermedicalscience 2015;9:599
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 26635903
PMC ID: PMC4664504

Principles of Systemic Therapy

Thomas A,  Szabo E
2015
Guitron J
Thoracic Oncology: A Multidisciplinary Approach
ISBN: 1118105524, 9781118105528
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer

Short- and long-term lung cancer risk associated with noncalcified nodules observed on low-dose CT.

Pinsky PF,  Nath PH,  Gierada DS,  Sonavane S,  Szabo E
Cancer Prev Res (Phila) 2014 Dec;7(12):1179-85
Major Program(s) or Research Group(s): Early DetectionLung and Upper Aerodigestive Cancer
PubMed ID: 24755313
PMC ID: PMC4206664

Early complications after laparoscopic gastric bypass surgery: results from the Scandinavian Obesity Surgery Registry.

Stenberg E,  Szabo E,  Agren G,  Näslund E,  Boman L,  Bylund A,  Hedenbro J,  Laurenius A,  LundegÃ¥rdh G,  Lönroth H,  Möller P,  Sundbom M,  Ottosson J,  Näslund I,  Scandinavian Obesity Surgery Registry Study Group
Ann Surg 2014 Dec;260(6):1040-7
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 24374541
PMC ID: not available

A phase I/II trial of belinostat in combination with cisplatin, doxorubicin, and cyclophosphamide in thymic epithelial tumors: a clinical and translational study.

Thomas A,  Rajan A,  Szabo E,  Tomita Y,  Carter CA,  Scepura B,  Lopez-Chavez A,  Lee MJ,  Redon CE,  Frosch A,  Peer CJ,  Chen Y,  Piekarz R,  Steinberg SM,  Trepel JB,  Figg WD,  Schrump DS,  Giaccone G
Clin Cancer Res 2014 Nov 1;20(21):5392-402
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 25189481
PMC ID: PMC4216756

PPARγ in head and neck cancer prevention.

Burotto M,  Szabo E
Oral Oncol 2014 Oct;50(10):924-9
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 24434068
PMC ID: PMC4096621

Metformin and cancer risk and mortality: a systematic review and meta-analysis taking into account biases and confounders.

Gandini S,  Puntoni M,  Heckman-Stoddard BM,  Dunn BK,  Ford L,  DeCensi A,  Szabo E
Cancer Prev Res (Phila) 2014 Sep;7(9):867-85
Major Program(s) or Research Group(s): Breast and Gynecologic CancerChemopreventive Agent DevelopmentLung and Upper Aerodigestive Cancer
PubMed ID: 24985407
PMC ID: PMC4154969

Images in clinical medicine. Sunitinib-associated hair depigmentation.

Brzezniak C,  Szabo E
N Engl J Med 2014 Apr 24;370(17):e27
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 24758639
PMC ID: not available

Cixutumumab for patients with recurrent or refractory advanced thymic epithelial tumours: a multicentre, open-label, phase 2 trial.

Rajan A,  Carter CA,  Berman A,  Cao L,  Kelly RJ,  Thomas A,  Khozin S,  Chavez AL,  Bergagnini I,  Scepura B,  Szabo E,  Lee MJ,  Trepel JB,  Browne SK,  Rosen LB,  Yu Y,  Steinberg SM,  Chen HX,  Riely GJ,  Giaccone G
Lancet Oncol 2014 Feb;15(2):191-200
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 24439931
PMC ID: PMC3954701

Fifty years of tobacco carcinogenesis research: from mechanisms to early detection and prevention of lung cancer.

Hecht SS,  Szabo E
Cancer Prev Res (Phila) 2014 Jan;7(1):1-8
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 24403288
PMC ID: PMC4296669

Developmental of Translational Sciences Based on Lung Cancer

Szabo E
2014
Srivastava R,  Maksymowicz W,  Lopaczynski W
Lost in Translation: Barriers to Incentives for Translational Research in Medical Sciences
ISBN: 978-981-4489-07-2; 978-981-4489-06-5
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer

A phase I/II study of sepantronium bromide (YM155, survivin suppressor) with paclitaxel and carboplatin in patients with advanced non-small-cell lung cancer.

Kelly RJ,  Thomas A,  Rajan A,  Chun G,  Lopez-Chavez A,  Szabo E,  Spencer S,  Carter CA,  Guha U,  Khozin S,  Poondru S,  Van Sant C,  Keating A,  Steinberg SM,  Figg W,  Giaccone G
Ann Oncol 2013 Oct;24(10):2601-6
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 23857959
PMC ID: PMC3784336

A phase I trial of aminolevulinic acid-photodynamic therapy for treatment of oral leukoplakia.

Wong SJ,  Campbell B,  Massey B,  Lynch DP,  Cohen EEW,  Blair E,  Selle R,  Shklovskaya J,  Jovanovic BD,  Skripkauskas S,  Dew A,  Kulesza P,  Parimi V,  Bergan RC,  Szabo E
Oral Oncol 2013 Sep;49(9):970-976
Major Program(s) or Research Group(s): Phase 0/I/II Cancer Prevention Clinical Trials ProgramLung and Upper Aerodigestive Cancer
PubMed ID: 23845699
PMC ID: PMC4456032

Effect of zileuton and celecoxib on urinary LTE4 and PGE-M levels in smokers.

Mohebati A,  Milne GL,  Zhou XK,  Duffield-Lillico AJ,  Boyle JO,  Knutson A,  Bosworth BP,  Kingsley PJ,  Marnett LJ,  Brown PH,  Akpa EG,  Szabo E,  Dannenberg AJ
Cancer Prev Res (Phila) 2013 Jul;6(7):646-55
Major Program(s) or Research Group(s): Phase 0/I/II Cancer Prevention Clinical Trials ProgramLung and Upper Aerodigestive Cancer
PubMed ID: 23682075
PMC ID: PMC3707304

Concurrent molecular alterations in tumors with germ line epidermal growth factor receptor T790M mutations.

Thomas A,  Xi L,  Carter CA,  Rajan A,  Khozin S,  Szabo E,  Dennis PA,  Giaccone G,  Raffeld M
Clin Lung Cancer 2013 Jul;14(4):452-6
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 23540867
PMC ID: PMC5002228

Effect of intermittent dosing regimens of erlotinib on methylnitrosourea-induced mammary carcinogenesis.

Lubet RA,  Szabo E,  Iwata KK,  Gill SC,  Tucker C,  Bode A,  Steele VE,  Juliana MM,  Nicastro HL,  Grubbs CJ
Cancer Prev Res (Phila) 2013 May;6(5):448-54
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive CancerChemopreventive Agent Development
PubMed ID: 23531447
PMC ID: PMC3813957

Chemoprevention of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines.

Szabo E,  Mao JT,  Lam S,  Reid ME,  Keith RL
Chest 2013 May;143(5 Suppl):e40S-e60S
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 23649449
PMC ID: PMC3749715

Population pharmacokinetic model for cancer chemoprevention with sulindac in healthy subjects.

Berg AK,  Mandrekar SJ,  Ziegler KL,  Carlson EC,  Szabo E,  Ames MM,  Boring D,  Limburg PJ,  Reid JM,  Cancer Prevention Network
J Clin Pharmacol 2013 Apr;53(4):403-12
Major Program(s) or Research Group(s): Phase 0/I/II Cancer Prevention Clinical Trials ProgramLung and Upper Aerodigestive CancerChemopreventive Agent Development
PubMed ID: 23436338
PMC ID: PMC4120995

18F-fluorodeoxyglucose positron emission tomography in the management of patients with thymic epithelial tumors.

Thomas A,  Mena E,  Kurdziel K,  Venzon D,  Khozin S,  Berman AW,  Choyke P,  Szabo E,  Rajan A,  Giaccone G
Clin Cancer Res 2013 Mar 15;19(6):1487-93
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 23382114
PMC ID: PMC3602145

Randomized phase II trial of sulindac for lung cancer chemoprevention.

Limburg PJ,  Mandrekar SJ,  Aubry MC,  Ziegler KL,  Zhang J,  Yi JE,  Henry M,  Tazelaar HD,  Lam S,  McWilliams A,  Midthun DE,  Edell ES,  Rickman OB,  Mazzone P,  Tockman M,  Beamis JF,  Lamb C,  Simoff M,  Loprinzi C,  Szabo E,  Jett J,  Cancer Prevention Network
Lung Cancer 2013 Mar;79(3):254-61
Major Program(s) or Research Group(s): Phase 0/I/II Cancer Prevention Clinical Trials ProgramLung and Upper Aerodigestive Cancer
PubMed ID: 23261228
PMC ID: PMC3566344

Characterization and management of cardiac involvement of thymic epithelial tumors.

Thomas A,  Shanbhag S,  Haglund K,  Berman A,  Jakopovic M,  Szabo E,  Arai A,  Schrump DS,  Kwong KF,  Rajan A,  Giaccone G
J Thorac Oncol 2013 Feb;8(2):246-9
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 23328550
PMC ID: PMC3552332

Chemopreventive effect of a mixture of Chinese Herbs (antitumor B) on chemically induced oral carcinogenesis.

Wang Y,  Yao R,  Gao S,  Wen W,  Du Y,  Szabo E,  Hu M,  Lubet RA,  You M
Mol Carcinog 2013 Jan;52(1):49-56
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive CancerChemopreventive Agent Development
PubMed ID: 22086836
PMC ID: not available

Validation of LOH profiles for assessing oral cancer risk.

Lingen MW,  Szabo E
Cancer Prev Res (Phila) 2012 Sep;5(9):1075-7
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 22911110
PMC ID: PMC3435466

A web-based screening and accrual strategy for a cancer prevention clinical trial in healthy smokers.

Mohebati A,  Knutson A,  Zhou XK,  Smith JJ,  Brown PH,  Dannenberg AJ,  Szabo E
Contemp Clin Trials 2012 Sep;33(5):942-8
Major Program(s) or Research Group(s): Phase 0/I/II Cancer Prevention Clinical Trials ProgramLung and Upper Aerodigestive Cancer
PubMed ID: 22771576
PMC ID: PMC3460548

A phase I combination study of olaparib with cisplatin and gemcitabine in adults with solid tumors.

Rajan A,  Carter CA,  Kelly RJ,  Gutierrez M,  Kummar S,  Szabo E,  Yancey MA,  Ji J,  Mannargudi B,  Woo S,  Spencer S,  Figg WD,  Giaccone G
Clin Cancer Res 2012 Apr 15;18(8):2344-51
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 22371451
PMC ID: PMC6368967

Chemoprevention of lung carcinogenesis by the combination of aerosolized budesonide and oral pioglitazone in A/J mice.

Fu H,  Zhang J,  Pan J,  Zhang Q,  Lu Y,  Wen W,  Lubet RA,  Szabo E,  Chen R,  Wang Y,  Chen DR,  You M
Mol Carcinog 2011 Dec;50(12):913-21
Major Program(s) or Research Group(s): Chemopreventive Agent DevelopmentLung and Upper Aerodigestive Cancer
PubMed ID: 21374736
PMC ID: PMC6015734

Criteria of evidence to move potential chemopreventive agents into late phase clinical trials.

Kelly RJ,  Lopez-Chavez A,  Szabo E
Curr Drug Targets 2011 Dec;12(13):1983-8
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 21158704
PMC ID: not available

Lung cancer chemoprevention with celecoxib in former smokers.

Mao JT,  Roth MD,  Fishbein MC,  Aberle DR,  Zhang ZF,  Rao JY,  Tashkin DP,  Goodglick L,  Holmes EC,  Cameron RB,  Dubinett SM,  Elashoff R,  Szabo E,  Elashoff D
Cancer Prev Res (Phila) 2011 Jul;4(7):984-93
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 21733822
PMC ID: PMC3153413

Altered histology provides a positive clinical signal in the bronchial epithelium.

Szabo E
Cancer Prev Res (Phila) 2011 Jun;4(6):775-8
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 21636542
PMC ID: PMC3110761

Phase II study of belinostat in patients with recurrent or refractory advanced thymic epithelial tumors.

Giaccone G,  Rajan A,  Berman A,  Kelly RJ,  Szabo E,  Lopez-Chavez A,  Trepel J,  Lee MJ,  Cao L,  Espinoza-Delgado I,  Spittler J,  Loehrer PJ Sr
J Clin Oncol 2011 May 20;29(15):2052-9
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 21502553
PMC ID: PMC3107761

The Ninth Annual American Association of cancer research international conference on frontiers in cancer prevention research.

Xu L,  Wang SS,  Healey MA,  Faupel-Badger JM,  Wilken JA,  Battaglia T,  Szabo E,  Mao JT,  Bergan RC
Cancer Prev Res (Phila) 2011 Apr;4(4):616-21
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 21464034
PMC ID: PMC4827425

Regulatory approval of cancer risk-reducing (chemopreventive) drugs: moving what we have learned into the clinic.

Meyskens FL Jr,  Curt GA,  Brenner DE,  Gordon G,  Herberman RB,  Finn O,  Kelloff GJ,  Khleif SN,  Sigman CC,  Szabo E,  C-Change Chemoprevention Clinical Trials and Biomarkers Subcommittee
Cancer Prev Res (Phila) 2011 Mar;4(3):311-23
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 21372031
PMC ID: PMC3059243

Phase 0 clinical chemoprevention trial of the Akt inhibitor SR13668.

Reid JM,  Walden CA,  Qin R,  Ziegler KL,  Haslam JL,  Rajewski RA,  Warndahl R,  Fitting CL,  Boring D,  Szabo E,  Crowell J,  Perloff M,  Jong L,  Bauer BA,  Mandrekar SJ,  Ames MM,  Limburg PJ,  Cancer Prevention Network
Cancer Prev Res (Phila) 2011 Mar;4(3):347-53
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive CancerChemopreventive Agent DevelopmentPhase 0/I/II Cancer Prevention Clinical Trials Program
PubMed ID: 21372034
PMC ID: PMC3061470

Genetic variants in the FADS gene cluster are associated with arachidonic acid concentrations of human breast milk at 1.5 and 6 mo postpartum and influence the course of milk dodecanoic, tetracosenoic, and trans-9-octadecenoic acid concentrations over the duration of lactation.

Lattka E,  Rzehak P,  Szabó É,  Jakobik V,  Weck M,  Weyermann M,  Grallert H,  Rothenbacher D,  Heinrich J,  Brenner H,  Decsi T,  Illig T,  Koletzko B
Am J Clin Nutr 2011 Feb;93(2):382-91
PubMed ID: 21147856
PMC ID: not available

Randomized phase II trial of inhaled budesonide versus placebo in high-risk individuals with CT screen-detected lung nodules.

Veronesi G,  Szabo E,  Decensi A,  Guerrieri-Gonzaga A,  Bellomi M,  Radice D,  Ferretti S,  Pelosi G,  Lazzeroni M,  Serrano D,  Lippman SM,  Spaggiari L,  Nardi-Pantoli A,  Harari S,  Varricchio C,  Bonanni B
Cancer Prev Res (Phila) 2011 Jan;4(1):34-42
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive CancerPhase 0/I/II Cancer Prevention Clinical Trials Program
PubMed ID: 21163939
PMC ID: PMC3017323

Screening and Prevention of Lung Cancer

Doria-Rose VP,  Szabo E
2011
Kernstine KH,  Rechamp KL
Lung Cancer: A Multidisciplinary Approach to Diagnosis and Management
ISBN: 978-1-936287-06-2
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer

Abstract PR-10: Randomized placebo controlled trial of pioglitazone for oral premalignant lesions: A cross-consortium collaborative study in progress.

Boyle JO,  Ondrey FG,  Brown PH,  Bailey HH,  Kim KM,  El-Naggar AK,  Szabo EM
Cancer Prev Res 2010 Dec;3(12 Suppl):PR-10
Major Program(s) or Research Group(s): Phase 0/I/II Cancer Prevention Clinical Trials Program
PubMed ID: not available
PMC ID: not available

Budesonide versus placebo in high-risk population with screen-detected lung nodules: rationale, design and methodology.

Lazzeroni M,  Guerrieri-Gonzaga A,  Serrano D,  Varricchio MC,  Veronesi G,  Radice D,  Feroce I,  Nardi-Pantoli A,  Lippman SM,  Szabo E,  Bonanni B
Contemp Clin Trials 2010 Nov;31(6):612-9
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive CancerPhase 0/I/II Cancer Prevention Clinical Trials Program
PubMed ID: 20719253
PMC ID: PMC2962433

Chemopreventive effects of pioglitazone on chemically induced lung carcinogenesis in mice.

Wang Y,  James M,  Wen W,  Lu Y,  Szabo E,  Lubet RA,  You M
Mol Cancer Ther 2010 Nov;9(11):3074-82
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive CancerChemopreventive Agent Development
PubMed ID: 21045137
PMC ID: not available

Phase II cancer prevention clinical trials.

Szabo E
Semin Oncol 2010 Aug;37(4):359-66
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 20816506
PMC ID: PMC2935910

Sustained response of carcinoma ex pleomorphic adenoma treated with trastuzumab and capecitabine.

Sharon E,  Kelly RJ,  Szabo E
Head Neck Oncol 2010 May 26;2:12
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 20504363
PMC ID: PMC2889991

Cancer and inflammation: promise for biologic therapy.

Demaria S,  Pikarsky E,  Karin M,  Coussens LM,  Chen YC,  El-Omar EM,  Trinchieri G,  Dubinett SM,  Mao JT,  Szabo E,  Krieg A,  Weiner GJ,  Fox BA,  Coukos G,  Wang E,  Abraham RT,  Carbone M,  Lotze MT
J Immunother 2010 May;33(4):335-51
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 20386472
PMC ID: PMC2941912

Airway PI3K pathway activation is an early and reversible event in lung cancer development.

Gustafson AM,  Soldi R,  Anderlind C,  Scholand MB,  Qian J,  Zhang X,  Cooper K,  Walker D,  McWilliams A,  Liu G,  Szabo E,  Brody J,  Massion PP,  Lenburg ME,  Lam S,  Bild AH,  Spira A
Sci Transl Med 2010 Apr 7;2(26):26ra25
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 20375364
PMC ID: PMC3694402

Assessing efficacy in early-phase cancer prevention clinical trials: the case of ki-67 in the lung.

Szabo E
Cancer Prev Res (Phila) 2010 Feb;3(2):128-31
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 20103726
PMC ID: PMC2818869

Somatic Evolution in Neoplastic Progression and Cancer Prevention

Maley CC,  Szabo E,  Reid BJ
2010
Fitzgerald RC
Pre-Invasive Disease: Pathogenesis and Clinical Management
ISBN: 978-1-4419-6693-3
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer

Randomized controlled trials of the efficacy of lung cancer screening by sputum cytology revisited: a combined mortality analysis from the Johns Hopkins Lung Project and the Memorial Sloan-Kettering Lung Study.

Doria-Rose VP,  Marcus PM,  Szabo E,  Tockman MS,  Melamed MR,  Prorok PC
Cancer 2009 Nov 1;115(21):5007-17
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive CancerBiometry
PubMed ID: 19637354
PMC ID: PMC2767423

Lung cancer and chronic obstructive pulmonary disease: needs and opportunities for integrated research.

Punturieri A,  Szabo E,  Croxton TL,  Shapiro SD,  Dubinett SM
J Natl Cancer Inst 2009 Apr 15;101(8):554-9
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 19351920
PMC ID: PMC2669099

Randomized phase II trial of budesonide versus placebo in high-risk population with screening-detected lung nodules: Update on secondary endpoints.

Bonanni B,  Guerrieri-Gonzaga A,  Radice D,  Serrano D,  Varricchio C,  Ferretti S,  Johansson H,  Szabo E,  Decensi A,  Veronesi G
J Clin Oncol 2009;27(17S):1518
Major Program(s) or Research Group(s): Phase 0/I/II Cancer Prevention Clinical Trials Program
PubMed ID: not available
PMC ID: not available

Assessing efficacy in early-phase cancer prevention trials: the case of oral premalignancy.

Szabo E
Cancer Prev Res (Phila) 2008 Oct;1(5):312-5
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 19138975
PMC ID: not available

Meeting report: Sixth Annual AACR International Conference on Frontiers in Cancer Prevention Research.

Girnun GD,  Howe LR,  Manne S,  Mao JT,  Reid ME,  Szabo E
Cancer Prev Res (Phila) 2008 Jul;1(2):146-9
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 19138947
PMC ID: not available

Primer: first do no harm--when is it appropriate to plan a cancer prevention clinical trial?

Szabo E
Nat Clin Pract Oncol 2008 Jun;5(6):348-56
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 18446144
PMC ID: not available

Effects of gefitinib (Iressa) on mammary cancers: preventive studies with varied dosages, combinations with vorozole or targretin, and biomarker changes.

Lubet RA,  Szabo E,  Christov K,  Bode AM,  Ericson ME,  Steele VE,  Juliana MM,  Grubbs CJ
Mol Cancer Ther 2008 Apr;7(4):972-9
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive CancerChemopreventive Agent Development
PubMed ID: 18375820
PMC ID: not available

Higher levels of the anti-inflammatory protein CC10 are associated with improvement in bronchial dysplasia and sputum cytometric assessment in individuals at high risk for lung cancer.

Chen J,  Lam S,  Pilon A,  McWilliams A,  Macaulay C,  Szabo E
Clin Cancer Res 2008 Mar 1;14(5):1590-7
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 18316584
PMC ID: not available

Comparative bioavailability of sulindac in capsule and tablet formulations.

Reid JM,  Mandrekar SJ,  Carlson EC,  Harmsen WS,  Green EM,  McGovern RM,  Szabo E,  Ames MM,  Boring D,  Limburg PJ,  Cancer Prevention Network
Cancer Epidemiol Biomarkers Prev 2008 Mar;17(3):674-9
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive CancerPhase 0/I/II Cancer Prevention Clinical Trials ProgramChemopreventive Agent Development
PubMed ID: 18349286
PMC ID: PMC2435402

Proliferative changes in chemoprevention trials: learning from secondary endpoints.

Szabo E
J Natl Cancer Inst 2007 Nov 7;99(21):1565-7
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 17971524
PMC ID: not available

Lung cancer chemoprevention: ACCP evidence-based clinical practice guidelines (2nd Edition).

Gray J,  Mao JT,  Szabo E,  Kelley M,  Kurie J,  Bepler G,  American College of Chest Physicians
Chest 2007 Sep;132(3 Suppl):56S-68S
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 17873160
PMC ID: not available

The association between the anti-inflammatory protein CC10 and smoking status among participants in a chemoprevention trial.

Chen J,  Lam S,  Pilon A,  McWilliams A,  Melby J,  Szabo E
Cancer Epidemiol Biomarkers Prev 2007 Mar;16(3):577-83
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 17372255
PMC ID: not available

Workshop on imaging science development for cancer prevention and preemption.

Kelloff GJ,  Sullivan DC,  Baker H,  Clarke LP,  Nordstrom R,  Tatum JL,  Dorfman GS,  Jacobs P,  Berg CD,  Pomper MG,  Birrer MJ,  Tempero M,  Higley HR,  Petty BG,  Sigman CC,  Maley C,  Sharma P,  Wax A,  Ginsberg GG,  Dannenberg AJ,  Hawk ET,  Messing EM,  Grossman HB,  Harisinghani M,  Bigio IJ,  Griebel D,  Henson DE,  Fabian CJ,  Ferrara K,  Fantini S,  Schnall MD,  Zujewski JA,  Hayes W,  Klein EA,  DeMarzo A,  Ocak I,  Ketterling JA,  Tempany C,  Shtern F,  Parnes HL,  Gomez J,  Srivastava S,  Szabo E,  Lam S,  Seibel EJ,  Massion P,  McLennan G,  Cleary K,  Suh R,  Burt RW,  Pfeiffer RM,  Hoffman JM,  Roy HK,  Wang T,  Limburg PJ,  El-Deiry WS,  Papadimitrakopoulou V,  Hittelman WN,  MacAulay C,  Veltri RW,  Solomon D,  Jeronimo J,  Richards-Kortum R,  Johnson KA,  Viner JL,  Stratton SP,  Rajadhyaksha M,  Dhawan A,  Workshop Program Committee
Cancer Biomark 2007;3(1):1-33
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive CancerBreast and Gynecologic CancerProstate and Urologic Cancer
PubMed ID: 17655039
PMC ID: not available

Selecting targets for cancer prevention: where do we go from here?

Szabo E
Nat Rev Cancer 2006 Nov;6(11):867-74
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 17036038
PMC ID: not available

A phase I study of myo-inositol for lung cancer chemoprevention.

Lam S,  McWilliams A,  LeRiche J,  MacAulay C,  Wattenberg L,  Szabo E
Cancer Epidemiol Biomarkers Prev 2006 Aug;15(8):1526-31
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 16896044
PMC ID: not available

Progress in chemoprevention drug development: the promise of molecular biomarkers for prevention of intraepithelial neoplasia and cancer--a plan to move forward.

Kelloff GJ,  Lippman SM,  Dannenberg AJ,  Sigman CC,  Pearce HL,  Reid BJ,  Szabo E,  Jordan VC,  Spitz MR,  Mills GB,  Papadimitrakopoulou VA,  Lotan R,  Aggarwal BB,  Bresalier RS,  Kim J,  Arun B,  Lu KH,  Thomas ME,  Rhodes HE,  Brewer MA,  Follen M,  Shin DM,  Parnes HL,  Siegfried JM,  Evans AA,  Blot WJ,  Chow WH,  Blount PL,  Maley CC,  Wang KK,  Lam S,  Lee JJ,  Dubinett SM,  Engstrom PF,  Meyskens FL Jr,  O'Shaughnessy J,  Hawk ET,  Levin B,  Nelson WG,  Hong WK,  AACR Task Force on Cancer Prevention
Clin Cancer Res 2006 Jun 15;12(12):3661-97
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 16778094
PMC ID: not available

A phase I pharmacologic and pharmacogenetic trial of sequential 24-hour infusion of irinotecan followed by leucovorin and a 48-hour infusion of fluorouracil in adult patients with solid tumors.

Wright MA,  Morrison G,  Lin P,  Leonard GD,  Nguyen D,  Guo X,  Szabo E,  Hopkins JL,  Leguizamo JP,  Harold N,  Fioravanti S,  Schuler B,  Monahan BP,  Saif MW,  Quinn MG,  Pang J,  Grem JL
Clin Cancer Res 2005 Jun 1;11(11):4144-50
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 15930350
PMC ID: not available

Diet and cancer: the disconnect between epidemiology and randomized clinical trials.

Meyskens FL Jr,  Szabo E
Cancer Epidemiol Biomarkers Prev 2005 Jun;14(6):1366-9
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 15941942
PMC ID: not available

Phase I and pharmacologic study of 17-(allylamino)-17-demethoxygeldanamycin in adult patients with solid tumors.

Grem JL,  Morrison G,  Guo XD,  Agnew E,  Takimoto CH,  Thomas R,  Szabo E,  Grochow L,  Grollman F,  Hamilton JM,  Neckers L,  Wilson RH
J Clin Oncol 2005 Mar 20;23(9):1885-93
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 15774780
PMC ID: not available

How should we move the field of chemopreventive agent development forward in a productive manner?

Meyskens FL,  Szabo E
Recent Results Cancer Res 2005;166:113-24
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 15648187
PMC ID: not available

Multiagent Chemoprevention - Clinical Concepts

Szabo E
2005
American Society of Clinical Oncology 2005 Educational Book
ISBN: not available
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer

A randomized phase IIb trial of pulmicort turbuhaler (budesonide) in people with dysplasia of the bronchial epithelium.

Lam S,  leRiche JC,  McWilliams A,  Macaulay C,  Dyachkova Y,  Szabo E,  Mayo J,  Schellenberg R,  Coldman A,  Hawk E,  Gazdar A
Clin Cancer Res 2004 Oct 1;10(19):6502-11
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 15475437
PMC ID: not available

Use of markers for the detection and treatment of lung cancer.

Vourlekis JS,  Szabo E
Dis Markers 2004;20(2):71-85
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 15322315
PMC ID: PMC3839279

Lung cancer screening: a different paradigm.

McWilliams A,  Mayo J,  MacDonald S,  leRiche JC,  Palcic B,  Szabo E,  Lam S
Am J Respir Crit Care Med 2003 Nov 15;168(10):1167-73
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 12882756
PMC ID: not available

Major conceptual change required to improve lung cancer: see a respiratory physician.

Vourlekis JS,  Szabo E
Eur Respir J 2003 Nov;22(5):866
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 14621099
PMC ID: not available

Pharmacokinetic and pharmacodynamic effects of oral eniluracil, fluorouracil and leucovorin given on a weekly schedule.

Guo XD,  Harold N,  Saif MW,  Schuler B,  Szabo E,  Hamilton JM,  Monahan BP,  Quinn MG,  Cliatt J,  Nguyen D,  Grollman F,  Thomas RR,  McQuigan EA,  Wilson R,  Takimoto CH,  Grem JL
Cancer Chemother Pharmacol 2003 Jul;52(1):79-85
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 12707718
PMC ID: not available

Sustained partial response of an intra-abdominal desmoid tumor treated with gemcitabine, 5-fluorouracil and leucovorin.

Wright MA,  Schuler B,  Szabo E,  Grem JL
Ann Oncol 2003 Apr;14(4):659-60
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 12649120
PMC ID: not available

Predicting success in cancer prevention trials.

Vourlekis JS,  Szabo E
J Natl Cancer Inst 2003 Feb 5;95(3):178-9
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 12569132
PMC ID: not available

MUC1 Expression in Lung Cancer

Szabo E
2003
Driscoll B
Lung Cancer: Volume 1 Molecular Pathology Methods and Reviews
Methods in Molecular Medicine
ISBN: 978-0-89603-985-8; 978-1-4899-3912-8
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer

MUC1 expression in lung cancer.

Szabo E
Methods Mol Med 2003;74:251-8
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 12415700
PMC ID: not available

Chemoprevention of lung cancer: new directions.

Szabo E,  Kalebic T
Recent Results Cancer Res 2003;163:172-6
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 12903853
PMC ID: not available

Prevention of mouse lung tumors by budesonide and its modulation of biomarkers.

Pereira MA,  Li Y,  Gunning WT,  Kramer PM,  Al-Yaqoub F,  Lubet RA,  Steele VE,  Szabo E,  Tao L
Carcinogenesis 2002 Jul;23(7):1185-92
Major Program(s) or Research Group(s): Chemopreventive Agent DevelopmentLung and Upper Aerodigestive Cancer
PubMed ID: 12117777
PMC ID: not available

Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-gamma and inhibitors of histone deacetylase in adenocarcinoma of the lung.

Chang TH,  Szabo E
Clin Cancer Res 2002 Apr;8(4):1206-12
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 11948134
PMC ID: not available

Lung epithelial proliferation: a biomarker for chemoprevention trials?

Szabo E
J Natl Cancer Inst 2001 Jul 18;93(14):1042-3
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 11459858
PMC ID: not available

Book review: Lung Cancer Therapy Annual 2000

Szabo E
Oncology 2001;15:109
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: not available
PMC ID: not available

Induction of differentiation and apoptosis by ligands of peroxisome proliferator-activated receptor gamma in non-small cell lung cancer.

Chang TH,  Szabo E
Cancer Res 2000 Feb 15;60(4):1129-38
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 10706135
PMC ID: not available

The role of CC10 in pulmonary carcinogenesis: from a marker to tumor suppression.

Linnoila RI,  Szabo E,  DeMayo F,  Witschi H,  Sabourin C,  Malkinson A
Ann N Y Acad Sci 2000;923:249-67
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 11193761
PMC ID: not available

Induction of differentiation accompanies inhibition of Cdk2 in a non-small cell lung cancer cell line.

Lee HR,  Chang TH,  Tebalt MJ 3rd,  Senderowicz AM,  Szabo E
Int J Oncol 1999 Jul;15(1):161-6
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 10375610
PMC ID: not available

MUC1 is a novel marker for the type II pneumocyte lineage during lung carcinogenesis.

Jarrard JA,  Linnoila RI,  Lee H,  Steinberg SM,  Witschi H,  Szabo E
Cancer Res 1998 Dec 1;58(23):5582-9
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 9850098
PMC ID: not available

Overexpression of CC10 modifies neoplastic potential in lung cancer cells.

Szabo E,  Goheer A,  Witschi H,  Linnoila RI
Cell Growth Differ 1998 Jun;9(6):475-85
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 9663466
PMC ID: not available

Alterations in differentiation and apoptosis induced by bufalin in cJun overexpressing U-937 cells.

Szabo E,  Francis J,  Birrer MJ
Int J Oncol 1998 Feb;12(2):403-9
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 9458368
PMC ID: not available

Coordinate regulation of stress- and mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine.

Jarvis WD,  Fornari FA Jr,  Auer KL,  Freemerman AJ,  Szabo E,  Birrer MJ,  Johnson CR,  Barbour SE,  Dent P,  Grant S
Mol Pharmacol 1997 Dec;52(6):935-47
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 9415703
PMC ID: not available

New approaches to the integrated management of early lung cancer.

Mulshine JL,  Zhou J,  Treston AM,  Szabo E,  Tockman MS,  Cuttitta F
Hematol Oncol Clin North Am 1997 Apr;11(2):235-52
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 9137968
PMC ID: not available

Intermediate Markers and Molecular Genetics of Lung Carcinogenesis.

Szabo E,  Shaw GL
Cancer Control 1997 Mar;4(2):109-117
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 10763008
PMC ID: not available

Role of c-jun in human myeloid leukemia cell apoptosis induced by pharmacological inhibitors of protein kinase C.

Freemerman AJ,  Turner AJ,  Birrer MJ,  Szabo E,  Valerie K,  Grant S
Mol Pharmacol 1996 May;49(5):788-95
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 8622627
PMC ID: not available

Effect of 1-beta-D-arabinofuranosylcytosine on apoptosis and differentiation in human monocytic leukemia cells (U937) expressing a c-Jun dominant-negative mutant protein (TAM67).

Grant S,  Freemerman AJ,  Birrer MJ,  Martin HA,  Turner AJ,  Szabo E,  Chelliah J,  Jarvis WD
Cell Growth Differ 1996 May;7(5):603-13
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 8732670
PMC ID: not available

Development of Molecular Approaches to Early Lung Cancer Detection.

Mulshine JL,  Scott F,  Zhou J,  Avis I I,  Vos M,  Miller MJ,  Szabo E,  Martinez A,  Treston AM,  Cuttitta F,  Tockman M
Semin Radiat Oncol 1996 Apr;6(2):72-75
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 10717164
PMC ID: not available

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.

Verheij M,  Bose R,  Lin XH,  Yao B,  Jarvis WD,  Grant S,  Birrer MJ,  Szabo E,  Zon LI,  Kyriakis JM,  Haimovitz-Friedman A,  Fuks Z,  Kolesnick RN
Nature 1996 Mar 7;380(6569):75-9
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 8598911
PMC ID: not available

Altered cJUN expression: an early event in human lung carcinogenesis.

Szabo E,  Riffe ME,  Steinberg SM,  Birrer MJ,  Linnoila RI
Cancer Res 1996 Jan 15;56(2):305-15
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 8542585
PMC ID: not available

Bryostatin 1 Potentiates 1-[Beta-D-Arabinofuranosyl]Cytosine-Mediated Antiproliferative Effects in c-jun Dominant-Negative Human Myeloid Leukemia Cells (U937/TAM67) through a Nonapoptotic Mechanism

Freemerman AJ,  Maloney NJ,  Birrer MJ,  Szabo E,  Grant S
Molec & Cell Differentiation 1996;4:247-262
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: not available
PMC ID: not available

Screening and Secondary Prevention of Lung Cancer

Szabo E,  Mulshine JL
1996
Aisner J,  Arriagada R,  Green MR,  Martini N,  Perry MC
Comprehensive Textbook of Thoracic Oncology
ISBN: 0683000624; 978-0805858518
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer

Primary and Secondary Prevention of Lung Cancer: an International Association for the Study of Lung Cancer workshop.

Battey JF,  Brown PH,  Gritz ER,  Hong WK,  Johnson BE,  Karp DD,  Mulshine JL,  Shaw GL,  Shopland DR,  Sunday ME,  Szabo E
Lung Cancer 1995 Mar;12(1-2):91-103
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 7600036
PMC ID: not available

The Screening for and Early Detection of Lung Cancer

Mulshine JL,  Szabo E,  Scott F
1995
Carney DN
Lung Cancer
ISBN: 0340567597; 978-0340567593
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer

Constitutive cJun expression induces partial macrophage differentiation in U-937 cells.

Szabo E,  Preis LH,  Birrer MJ
Cell Growth Differ 1994 Apr;5(4):439-46
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 8043518
PMC ID: not available

Oncogenes, Cancer, and Growth Factors

Szabo E,  Birrer MJ
1994
Barnes PJ,  Stockley RA
Molecular Biology of Lung Disease
ISBN: not available
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer

Early detection of lung cancer.

Szabo E,  Birrer MJ,  Mulshine JL
Semin Oncol 1993 Aug;20(4):374-82
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 8342067
PMC ID: not available

Suppression of oncogene-induced transformation by a deletion mutant of c-jun.

Brown PH,  Alani R,  Preis LH,  Szabo E,  Birrer MJ
Oncogene 1993 Apr;8(4):877-86
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 8455942
PMC ID: not available

Epidemiology, prognostic factors, and prevention of lung cancer.

Szabo E,  Mulshine J
Curr Opin Oncol 1993 Mar;5(2):302-9
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 8457617
PMC ID: not available

Early events in the neoplastic transformation of respiratory epithelium.

Birrer MJ,  Alani R,  Cuttitta F,  Preis LH,  Sabich AL,  Sanders DA,  Siegfried JM,  Szabo E,  Brown PH
J Natl Cancer Inst Monogr 1992 (13):31-7
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 1389694
PMC ID: not available

The role of jun and fos gene family members in 12-O-tetradecanoylphorbol-13-acetate induced hemopoietic differentiation.

Szabo E,  Preis LH,  Brown PH,  Birrer MJ
Cell Growth Differ 1991 Oct;2(10):475-82
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 1751404
PMC ID: not available

Immunocytochemical analysis of estrogen receptors as a predictor of prognosis in breast cancer patients: comparison with quantitative biochemical methods.

Kinsel LB,  Szabo E,  Greene GL,  Konrath J,  Leight GS,  McCarty KS Jr
Cancer Res 1989 Feb 15;49(4):1052-6
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 2643460
PMC ID: not available

Use of a monoclonal anti-estrogen receptor antibody in the immunohistochemical evaluation of human tumors.

McCarty KS Jr,  Szabo E,  Flowers JL,  Cox EB,  Leight GS,  Miller L,  Konrath J,  Soper JT,  Budwit DA,  Creasman WT
Cancer Res 1986 Aug;46(8 Suppl):4244s-4248s
Major Program(s) or Research Group(s): Lung and Upper Aerodigestive Cancer
PubMed ID: 3524805
PMC ID: not available