Publication Results

Generate Report

Add publications by marking their checkboxes, or

Screening of Chemopreventive Agents in Animal Models: Results on Reproducibility, Agents of a Given Class, and Agents Tested During Tumor Progression.

Lubet RA,  Steele VE,  Shoemaker RH,  Grubbs CJ
Cancer Prev Res (Phila) 2018 Oct;11(10):595-606
Major Program(s) or Research Group(s): Chemopreventive Agent Development
PubMed ID: 30045934
PMC ID: PMC6186395

Proteasome inhibition and mechanism of resistance to a synthetic, library-based hexapeptide.

Oerlemans R,  Berkers CR,  Assaraf YG,  Scheffer GL,  Peters GJ,  Verbrugge SE,  Cloos J,  Slootstra J,  Meloen RH,  Shoemaker RH,  Dijkmans BAC,  Scheper RJ,  Ovaa H,  Jansen G
Invest New Drugs 2018 Oct;36(5):797-809
Major Program(s) or Research Group(s): Chemopreventive Agent Development
PubMed ID: 29442210
PMC ID: PMC6153520

Airway brushing as a new experimental methodology to detect airway gene expression signatures in mouse lung squamous cell carcinoma.

Pan J,  Xiong D,  Zhang Q,  Szabo E,  Miller MS,  Lubet RA,  Wang Y,  You M
Sci Rep 2018 Jun 11;8(1):8895
Major Program(s) or Research Group(s): Chemopreventive Agent DevelopmentLung and Upper Aerodigestive Cancer
PubMed ID: 29891994
PMC ID: PMC5995924

Novel mutational landscapes and expression signatures of lung squamous cell carcinoma.

Xiong D,  Pan J,  Yin Y,  Jiang H,  Szabo E,  Lubet RA,  Wang Y,  You M
Oncotarget 2018 Jan 26;9(7):7424-7441
Major Program(s) or Research Group(s): Chemopreventive Agent DevelopmentLung and Upper Aerodigestive Cancer
PubMed ID: 29484121
PMC ID: PMC5800913

Lack of chemopreventive effects of P2X7R inhibitors against pancreatic cancer.

Mohammed A,  Janakiram NB,  Madka V,  Pathuri G,  Li Q,  Ritchie R,  Biddick L,  Kutche H,  Zhang Y,  Singh A,  Gali H,  Lightfoot S,  Steele VE,  Suen CS,  Rao CV
Oncotarget 2017 Nov 17;8(58):97822-97834
Major Program(s) or Research Group(s): Chemopreventive Agent DevelopmentProstate and Urologic Cancer
PubMed ID: 29228654
PMC ID: PMC5716694

Targeting "Retired Antigens" for Cancer Immunoprevention.

Shoemaker RH,  Forsthuber TG
Cancer Prev Res (Phila) 2017 Nov;10(11):607-608
Major Program(s) or Research Group(s): Chemopreventive Agent Development
PubMed ID: 29093010
PMC ID: not available

Early and late effects of aspirin and naproxen on microRNAs in the lung and blood of mice, either unexposed or exposed to cigarette smoke.

Izzotti A,  Balansky R,  Ganchev G,  Iltcheva M,  Longobardi M,  Pulliero A,  Camoirano A,  D'Agostini F,  Geretto M,  Micale RT,  La Maestra S,  Miller MS,  Steele VE,  De Flora S
Oncotarget 2017 Oct 17;8(49):85716-85748
Major Program(s) or Research Group(s): Chemopreventive Agent Development
PubMed ID: 29156752
PMC ID: PMC5689642

Immunoprevention of KRAS-driven lung adenocarcinoma by a multipeptide vaccine.

Pan J,  Zhang Q,  Sei S,  Shoemaker RH,  Lubet RA,  Wang Y,  You M
Oncotarget 2017 Oct 10;8(47):82689-82699
Major Program(s) or Research Group(s): Chemopreventive Agent Development
PubMed ID: 29137294
PMC ID: PMC5669920

Effect of weekly or daily dosing regimen of Gefitinib in mouse models of lung cancer.

Zhang Q,  Li R,  Chen X,  Lee SB,  Pan J,  Xiong D,  Hu J,  Miller MS,  Szabo E,  Lubet RA,  Wang Y,  You M
Oncotarget 2017 Sep 22;8(42):72447-72456
Major Program(s) or Research Group(s): Chemopreventive Agent DevelopmentLung and Upper Aerodigestive Cancer
PubMed ID: 29069801
PMC ID: PMC5641144

Loss of natural killer T cells promotes pancreatic cancer in LSL-KrasG12D/+ mice.

Janakiram NB,  Mohammed A,  Bryant T,  Ritchie R,  Stratton N,  Jackson L,  Lightfoot S,  Benbrook DM,  Asch AS,  Lang ML,  Rao CV
Immunology 2017 Sep;152(1):36-51
Major Program(s) or Research Group(s): Chemopreventive Agent Development
PubMed ID: 28419443
PMC ID: PMC5543460

Lack of chemopreventive efficacy of metformin in rodent models of urinary bladder, head and neck, and colon/intestine cancer.

Thompson MD,  Lubet RA,  Mccormick DL,  Clapper ML,  Bode AM,  Juliana MM,  Moeinpour F,  Grubbs CJ
Oncol Lett 2017 Sep;14(3):3480-3486
Major Program(s) or Research Group(s): Chemopreventive Agent Development
PubMed ID: 28927103
PMC ID: PMC5587978

Pioglitazone-mediated reversal of elevated glucose metabolism in the airway epithelium of mouse lung adenocarcinomas.

Xiong D,  Pan J,  Zhang Q,  Szabo E,  Miller MS,  Lubet RA,  Wang Y,  You M
JCI Insight 2017 Jul 6;2(13)
Major Program(s) or Research Group(s): Chemopreventive Agent DevelopmentLung and Upper Aerodigestive Cancer
PubMed ID: 28679956
PMC ID: PMC5499364

Identification of a nucleoside analog active against adenosine kinase-expressing plasma cell malignancies.

Nayar U,  Sadek J,  Reichel J,  Hernandez-Hopkins D,  Akar G,  Barelli PJ,  Sahai MA,  Zhou H,  Totonchy J,  Jayabalan D,  Niesvizky R,  Guasparri I,  Hassane D,  Liu Y,  Sei S,  Shoemaker RH,  Warren JD,  Elemento O,  Kaye KM,  Cesarman E
J Clin Invest 2017 Jun 1;127(6):2066-2080
Major Program(s) or Research Group(s): Chemopreventive Agent Development
PubMed ID: 28504647
PMC ID: PMC5451239

Identification and characterization of enhancer agonist human cytotoxic T-cell epitopes of the human papillomavirus type 16 (HPV16) E6/E7.

Tsang KY,  Fantini M,  Fernando RI,  Palena C,  David JM,  Hodge JW,  Gabitzsch ES,  Jones FR,  Schlom J
Vaccine 2017 May 2;35(19):2605-2611
Major Program(s) or Research Group(s): Chemopreventive Agent Development
PubMed ID: 28389098
PMC ID: PMC5444324

Selenomethionine and methyl selenocysteine: multiple-dose pharmacokinetics in selenium-replete men.

Marshall JR,  Burk RF,  Payne Ondracek R,  Hill KE,  Perloff M,  Davis W,  Pili R,  George S,  Bergan R
Oncotarget 2017 Apr 18;8(16):26312-26322
Major Program(s) or Research Group(s): Chemopreventive Agent Development
PubMed ID: 28412747
PMC ID: PMC5432259

Bronchial airway gene expression signatures in mouse lung squamous cell carcinoma and their modulation by cancer chemopreventive agents.

Xiong D,  Pan J,  Zhang Q,  Szabo E,  Miller MS,  Lubet RA,  You M,  Wang Y
Oncotarget 2017 Mar 21;8(12):18885-18900
Major Program(s) or Research Group(s): Chemopreventive Agent DevelopmentLung and Upper Aerodigestive Cancer
PubMed ID: 27935865
PMC ID: PMC5386655

Fixed-Dose Combinations of Pioglitazone and Metformin for Lung Cancer Prevention.

Seabloom DE,  Galbraith AR,  Haynes AM,  Antonides JD,  Wuertz BR,  Miller WA,  Miller KA,  Steele VE,  Miller MS,  Clapper ML,  O'Sullivan MG,  Ondrey FG
Cancer Prev Res (Phila) 2017 Feb;10(2):116-123
Major Program(s) or Research Group(s): Chemopreventive Agent Development
PubMed ID: 28052934
PMC ID: PMC5690483

Safety and Preclinical Efficacy of Aerosol Pioglitazone on Lung Adenoma Prevention in A/J Mice.

Seabloom DE,  Galbraith AR,  Haynes AM,  Antonides JD,  Wuertz BR,  Miller WA,  Miller KA,  Steele VE,  Suen CS,  O'Sullivan MG,  Ondrey FG
Cancer Prev Res (Phila) 2017 Feb;10(2):124-132
Major Program(s) or Research Group(s): Chemopreventive Agent DevelopmentProstate and Urologic Cancer
PubMed ID: 27993834
PMC ID: PMC5687250

Blood and lung microRNAs as biomarkers of pulmonary tumorigenesis in cigarette smoke-exposed mice.

Izzotti A,  Balansky R,  Ganchev G,  Iltcheva M,  Longobardi M,  Pulliero A,  Geretto M,  Micale RT,  La Maestra S,  Miller MS,  Steele VE,  De Flora S
Oncotarget 2016 Dec 20;7(51):84758-84774
Major Program(s) or Research Group(s): Chemopreventive Agent Development
PubMed ID: 27713172
PMC ID: PMC5341294

Interactions between ethanol and cigarette smoke in a mouse lung carcinogenesis model.

Balansky R,  Ganchev G,  Iltcheva M,  Nikolov M,  La Maestra S,  Micale RT,  Steele VE,  De Flora S
Toxicology 2016 Dec 12;373:54-62
Major Program(s) or Research Group(s): Chemopreventive Agent Development
PubMed ID: 27840117
PMC ID: not available

Potentiating NK cell activity by combination of Rosuvastatin and Difluoromethylornithine for effective chemopreventive efficacy against Colon Cancer.

Janakiram NB,  Mohammed A,  Bryant T,  Zhang Y,  Brewer M,  Duff A,  Biddick L,  Singh A,  Lightfoot S,  Steele VE,  Rao CV
Sci Rep 2016 Nov 14;6:37046
Major Program(s) or Research Group(s): Chemopreventive Agent Development
PubMed ID: 27841323
PMC ID: PMC5107958

Epidermal growth factor receptor derived peptide vaccination to prevent lung adenocarcinoma formation: An in vivo study in a murine model of EGFR mutant lung cancer.

Ebben JD,  Lubet RA,  Gad E,  Disis ML,  You M
Mol Carcinog 2016 Nov;55(11):1517-1525
Major Program(s) or Research Group(s): Chemopreventive Agent Development
PubMed ID: 26346412
PMC ID: PMC6019616

Pancreatic Cancer Chemoprevention Translational Workshop: Meeting Report.

Miller MS,  Allen P,  Brentnall TA,  Goggins M,  Hruban RH,  Petersen GM,  Rao CV,  Whitcomb DC,  Brand RE,  Chari ST,  Klein AP,  Lubman DM,  Rhim AD,  Simeone DM,  Wolpin BM,  Umar A,  Srivastava S,  Steele VE,  Rinaudo JA
Pancreas 2016 Sep;45(8):1080-91
Major Program(s) or Research Group(s): Chemopreventive Agent DevelopmentCancer BiomarkersGastrointestinal and Other Cancers
PubMed ID: 27518363
PMC ID: PMC4988336

IL-8 signaling is involved in resistance of lung carcinoma cells to erlotinib.

Fernando RI,  Hamilton DH,  Dominguez C,  David JM,  McCampbell KK,  Palena C
Oncotarget 2016 Jul 5;7(27):42031-42044
Major Program(s) or Research Group(s): Chemopreventive Agent Development
PubMed ID: 27248176
PMC ID: PMC5173114

5MeCDDO Blocks Metabolic Activation but not Progression of Breast, Intestine, and Tongue Cancers. Is Antioxidant Response Element a Prevention Target?

Lubet RA,  Townsend R,  Clapper ML,  Juliana MM,  Steele VE,  McCormick DL,  Grubbs CJ
Cancer Prev Res (Phila) 2016 Jul;9(7):616-23
Major Program(s) or Research Group(s): Chemopreventive Agent Development
PubMed ID: 27150634
PMC ID: PMC4930704

The IDO1 selective inhibitor epacadostat enhances dendritic cell immunogenicity and lytic ability of tumor antigen-specific T cells.

Jochems C,  Fantini M,  Fernando RI,  Kwilas AR,  Donahue RN,  Lepone LM,  Grenga I,  Kim YS,  Brechbiel MW,  Gulley JL,  Madan RA,  Heery CR,  Hodge JW,  Newton R,  Schlom J,  Tsang KY
Oncotarget 2016 Jun 21;7(25):37762-37772
Major Program(s) or Research Group(s): Chemopreventive Agent Development
PubMed ID: 27192116
PMC ID: PMC5122347

Mammographic Density as a Biosensor of Tamoxifen Effectiveness in Adjuvant Endocrine Treatment of Breast Cancer: Opportunities and Implications.

Mullooly M,  Pfeiffer RM,  Nyante SJ,  Heckman-Stoddard BM,  Perloff M,  Jatoi I,  Brinton LA,  Aiello Bowles EJ,  Hoover RN,  Glass A,  Berrington de Gonzalez A,  Sherman ME,  Gierach GL
J Clin Oncol 2016 Jun 20;34(18):2093-7
Major Program(s) or Research Group(s): Breast and Gynecologic CancerChemopreventive Agent Development
PubMed ID: 27022110
PMC ID: PMC4962703

Selective inhibition by aspirin and naproxen of mainstream cigarette smoke-induced genotoxicity and lung tumors in female mice.

Balansky R,  Ganchev G,  Iltcheva M,  Micale RT,  La Maestra S,  D'Oria C,  Steele VE,  De Flora S
Arch Toxicol 2016 May;90(5):1251-60
Major Program(s) or Research Group(s): Chemopreventive Agent Development
PubMed ID: 26104855
PMC ID: not available

Symptoms and QOL as Predictors of Chemoprevention Adherence in NRG Oncology/NSABP Trial P-1.

Land SR,  Walcott FL,  Liu Q,  Wickerham DL,  Costantino JP,  Ganz PA
J Natl Cancer Inst 2016 Apr;108(4)
Major Program(s) or Research Group(s): Chemopreventive Agent Development
PubMed ID: 26615179
PMC ID: PMC4675829
Clinical Trials: Breast Cancer Prevention Trial (BCPT)

Global Mortality Impact of the 1957-1959 Influenza Pandemic.

Viboud C,  Simonsen L,  Fuentes R,  Flores J,  Miller MA,  Chowell G
J Infect Dis 2016 Mar 1;213(5):738-45
Major Program(s) or Research Group(s): Chemopreventive Agent Development
PubMed ID: 26908781
PMC ID: PMC4747626

Pharmacological Modulation of Lung Carcinogenesis in Smokers: Preclinical and Clinical Evidence.

De Flora S,  Ganchev G,  Iltcheva M,  La Maestra S,  Micale RT,  Steele VE,  Balansky R
Trends Pharmacol Sci 2016 Feb;37(2):120-142
Major Program(s) or Research Group(s): Chemopreventive Agent Development
PubMed ID: 26726119
PMC ID: PMC4728041

Introduction: Cancer chemoprevention and its context.

Dunn BK,  Umar A,  Richmond E
Semin Oncol 2016 Feb;43(1):19-21
Major Program(s) or Research Group(s): Chemopreventive Agent DevelopmentGastrointestinal and Other Cancers
PubMed ID: 26970121
PMC ID: PMC5166611

Repurposing old drugs to chemoprevention: the case of metformin.

Heckman-Stoddard BM,  Gandini S,  Puntoni M,  Dunn BK,  DeCensi A,  Szabo E
Semin Oncol 2016 Feb;43(1):123-133
Major Program(s) or Research Group(s): Breast and Gynecologic CancerChemopreventive Agent DevelopmentLung and Upper Aerodigestive Cancer
PubMed ID: 26970131
PMC ID: PMC4789107

Double-Blind, Randomized Trial of Alternative Letrozole Dosing Regimens in Postmenopausal Women with Increased Breast Cancer Risk.

López AM,  Pruthi S,  Boughey JC,  Perloff M,  Hsu CH,  Lang JE,  Ley M,  Frank D,  Taverna JA,  Chow HH
Cancer Prev Res (Phila) 2016 Feb;9(2):142-8
Major Program(s) or Research Group(s): Chemopreventive Agent Development
PubMed ID: 26667449
PMC ID: PMC4740217

The promise of omics-based approaches to cancer prevention.

Meerzaman D,  Dunn BK,  Lee M,  Chen Q,  Yan C,  Ross S
Semin Oncol 2016 Feb;43(1):36-48
Major Program(s) or Research Group(s): Chemopreventive Agent DevelopmentNutritional Science
PubMed ID: 26970123
PMC ID: not available

The National Cancer Institute's PREVENT Cancer Preclinical Drug Development Program: overview, current projects, animal models, agent development strategies, and molecular targets.

Shoemaker RH,  Suen CS,  Holmes CA,  Fay JR,  Steele VE
Semin Oncol 2016 Feb;43(1):189-197
Major Program(s) or Research Group(s): Chemopreventive Agent DevelopmentProstate and Urologic Cancer
PubMed ID: 26970137
PMC ID: PMC4789768

Mechanisms of nonsteroidal anti-inflammatory drugs in cancer prevention.

Umar A,  Steele VE,  Menter DG,  Hawk ET
Semin Oncol 2016 Feb;43(1):65-77
Major Program(s) or Research Group(s): Chemopreventive Agent DevelopmentGastrointestinal and Other Cancers
PubMed ID: 26970125
PMC ID: not available

Hereditary cancer syndromes as model systems for chemopreventive agent development.

Walcott FL,  Patel J,  Lubet R,  Rodriguez L,  Calzone KA
Semin Oncol 2016 Feb;43(1):134-145
Major Program(s) or Research Group(s): Chemopreventive Agent DevelopmentGastrointestinal and Other Cancers
PubMed ID: 26970132
PMC ID: not available

Immunologic approaches to cancer prevention-current status, challenges, and future perspectives.

Wojtowicz ME,  Dunn BK,  Umar A
Semin Oncol 2016 Feb;43(1):161-172
Major Program(s) or Research Group(s): Chemopreventive Agent DevelopmentGastrointestinal and Other CancersLung and Upper Aerodigestive Cancer
PubMed ID: 26970135
PMC ID: not available

Validation of a Stability-Indicating Method for Methylseleno-L-Cysteine (L-SeMC).

Canady K,  Cobb J,  Deardorff P,  Larson J,  White JM,  Boring D
J Chromatogr Sci 2016 Jan;54(1):22-7
Major Program(s) or Research Group(s): Chemopreventive Agent Development
PubMed ID: 26199341
PMC ID: PMC4681365

Targeting mTOR and p53 Signaling Inhibits Muscle Invasive Bladder Cancer In Vivo.

Madka V,  Mohammed A,  Li Q,  Zhang Y,  Biddick L,  Patlolla JM,  Lightfoot S,  Towner RA,  Wu XR,  Steele VE,  Kopelovich L,  Rao CV
Cancer Prev Res (Phila) 2016 Jan;9(1):53-62
Major Program(s) or Research Group(s): Chemopreventive Agent Development
PubMed ID: 26577454
PMC ID: PMC4839263

Simultaneous targeting of 5-LOX-COX and ODC block NNK-induced lung adenoma progression to adenocarcinoma in A/J mice.

Kumar G,  Patlolla JM,  Madka V,  Mohammed A,  Li Q,  Zhang Y,  Biddick L,  Singh A,  Gillaspy A,  Lightfoot S,  Steele VE,  Kopelovich L,  Rao CV
Am J Cancer Res 2016;6(5):894-909
Major Program(s) or Research Group(s): Chemopreventive Agent Development
PubMed ID: 27293987
PMC ID: PMC4889708

Predictive Value Tools as an Aid in Chemopreventive Agent Development.

Dunn BK,  Steele VE,  Fagerstrom RM,  Topp CF,  Ransohoff D,  Cunningham C,  Lubet R,  Ford LG,  Kramer BS
J Natl Cancer Inst 2015 Dec;107(12):djv259
Major Program(s) or Research Group(s): BiometryChemopreventive Agent Development ;  Office of the Director
PubMed ID: 26420882
PMC ID: PMC4862414

Phase Ib Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Patients with Barrett's Esophagus.

Joe AK,  Schnoll-Sussman F,  Bresalier RS,  Abrams JA,  Hibshoosh H,  Cheung K,  Friedman RA,  Yang CS,  Milne GL,  Liu DD,  Lee JJ,  Abdul K,  Bigg M,  Foreman J,  Su T,  Wang X,  Ahmed A,  Neugut AI,  Akpa E,  Lippman SM,  Perloff M,  Brown PH,  Lightdale CJ
Cancer Prev Res (Phila) 2015 Dec;8(12):1131-7
Major Program(s) or Research Group(s): Chemopreventive Agent Development
PubMed ID: 26471236
PMC ID: PMC4670789

Src is a novel potential off-target of RXR agonists, 9-cis-UAB30 and Targretin, in human breast cancer cells.

Kim MS,  Lim DY,  Kim JE,  Chen H,  Lubet RA,  Dong Z,  Bode AM
Mol Carcinog 2015 Dec;54(12):1596-604
Major Program(s) or Research Group(s): Chemopreventive Agent Development
PubMed ID: 25328014
PMC ID: PMC4402118

Modulation by aspirin and naproxen of nucleotide alterations and tumors in the lung of mice exposed to environmental cigarette smoke since birth.

La Maestra S,  D'Agostini F,  Izzotti A,  Micale RT,  Mastracci L,  Camoirano A,  Balansky R,  Trosko JE,  Steele VE,  De Flora S
Carcinogenesis 2015 Dec;36(12):1531-8
Major Program(s) or Research Group(s): Chemopreventive Agent Development
PubMed ID: 26464196
PMC ID: PMC4675832

Early and delayed intervention with rapamycin prevents NNK-induced lung adenocarcinoma in A/J mice.

Patlolla JM,  Kopelovich L,  Qian L,  Zhang Y,  Kumar G,  Madka V,  Mohammed A,  Biddick L,  Sadeghi M,  Lightfoot S,  Rao CV
Oncol Rep 2015 Dec;34(6):2925-34
Major Program(s) or Research Group(s): Chemopreventive Agent Development
PubMed ID: 26397133
PMC ID: PMC4735698

Legislation in the genomic era: the Affordable Care Act and genetic testing for cancer risk assessment.

Walcott FL,  Dunn BK
Genet Med 2015 Dec;17(12):962-4
Major Program(s) or Research Group(s): Chemopreventive Agent Development
PubMed ID: 25741860
PMC ID: not available

Simultaneous targeting of 5-LOX-COX and EGFR blocks progression of pancreatic ductal adenocarcinoma.

Rao CV,  Janakiram NB,  Madka V,  Devarkonda V,  Brewer M,  Biddick L,  Lightfoot S,  Steele VE,  Mohammed A
Oncotarget 2015 Oct 20;6(32):33290-305
Major Program(s) or Research Group(s): Chemopreventive Agent Development
PubMed ID: 26429877
PMC ID: PMC4741766

Metformin: risk-benefit profile with a focus on cancer.

Provinciali N,  Lazzeroni M,  Cazzaniga M,  Gorlero F,  Dunn BK,  DeCensi A
Expert Opin Drug Saf 2015 Oct;14(10):1573-85
Major Program(s) or Research Group(s): Chemopreventive Agent Development
PubMed ID: 26359221
PMC ID: not available