Optimizing dosing of oncology drugs.
Journal: Clin Pharmacol Ther
Date: 2014 Nov
Major Program(s) or Research Group(s): OD
PubMed ID: 25105705
PMC ID: not available
Abstract: The purpose of this article is to acknowledge the challenges in optimizing the dosing of oncology drugs and to propose potential approaches to address these challenges in order to optimize effectiveness, minimize toxicity, and promote adherence in patients. These approaches could provide better opportunities to understand the sources of variability in drug exposure and clinical outcomes during the development and premarketing evaluation of investigational new drugs.