Hepatoid adenocarcinoma of the lung metastasizing to the tonsil.

Author(s): Valle L,  Thomas J,  Kim C,  Szabo E,  Brown GT,  Citrin D,  Rajan A

Journal: Mol Clin Oncol

Date: 2017 May

Major Program(s) or Research Group(s): LUACRG

PubMed ID: 28529745

PMC ID: PMC5431682

Abstract: Hepatoid adenocarcinoma (HAC) is a rare tumor that typically originates in gastrointestinal tissue, such as the stomach, but can also occasionally originate in the lung. The majority of HACs express α-fetoprotein (AFP) on tumor cells, and serum AFP can be used as a marker of response to treatment or disease progression. HAC has a poor prognosis, although early diagnosis and aggressive treatment can result in long-term survival. To the best of our knowledge, this is the first reported case of HAC metastasizing to the tonsil. Irradiation using intensity-modulated radiation therapy (IMRT) to 30 Gray (Gy) achieved a significant, and durable tumor response. IMRT can be considered for local control of HAC at other metastatic sites of disease.