No evidence of gene-calcium interactions from genome-wide analysis of colorectal cancer risk.

Author(s): Du M,  Zhang X,  Hoffmeister M,  Schoen RE,  Baron JA,  Berndt SI,  Brenner H,  Carlson CS,  Casey G,  Chan AT,  Curtis KR,  Duggan D,  Gauderman WJ,  Giovannucci EL,  Gong J,  Harrison TA,  Hayes RB,  Henderson BE,  Hopper JL,  Hsu L,  Hudson TJ,  Hutter CM,  Jenkins MA,  Jiao S,  Kocarnik JM,  Kolonel LN,  Le Marchand L,  Lin Y,  Newcomb PA,  Rudolph A,  Seminara D,  Thornquist MD,  Ulrich CM,  White E,  Wu K,  Zanke BW,  Campbell PT,  Slattery ML,  Peters U,  Chang-Claude J,  Potter JD,  Colon Cancer Family Registry and Genetics and Epidemiology of Colorectal Cancer Consortium

Journal: Cancer Epidemiol Biomarkers Prev

Date: 2014 Dec

Major Program(s) or Research Group(s): PLCO

PubMed ID: 25192705

PMC ID: PMC4257872

Abstract: BACKGROUND: Calcium intake may reduce risk of colorectal cancer, but the mechanisms remain unclear. Studies of interaction between calcium intake and SNPs in calcium-related pathways have yielded inconsistent results. METHODS: To identify gene-calcium interactions, we tested interactions between approximately 2.7 million SNPs across the genome with self-reported calcium intake (from dietary or supplemental sources) in 9,006 colorectal cancer cases and 9,503 controls of European ancestry. To test for multiplicative interactions, we used multivariable logistic regression and defined statistical significance using the conventional genome-wide α = 5E-08. RESULTS: After accounting for multiple comparisons, there were no statistically significant SNP interactions with total, dietary, or supplemental calcium intake. CONCLUSIONS: We found no evidence of SNP interactions with calcium intake for colorectal cancer risk in a large population of 18,509 individuals. IMPACT: These results suggest that in genome-wide analysis common genetic variants do not strongly modify the association between calcium intake and colorectal cancer in European populations.