The association between Dietary Inflammatory Index scores and the prevalence of colorectal adenoma.

Author(s): Haslam A,  Wagner Robb S,  Hébert JR,  Huang H,  Wirth MD,  Shivappa N,  Ebell MH

Journal: Public Health Nutr

Date: 2017 Jun

Major Program(s) or Research Group(s): PLCO

PubMed ID: 28345504

PMC ID: not available

Abstract: OBJECTIVE: The Dietary Inflammatory Index (DII)TM, which was developed to characterize the inflammatory potential of a person's diet, has been shown to be associated with inflammatory conditions such as cancer. The present study aimed to investigate the association between DII scores and colorectal adenoma (CRA), a pre-cancerous condition. DESIGN: Responses to baseline dietary questionnaires were used calculate DII scores. In a cross-sectional study design, the association between DII scores and CRA prevalence was determined in men and women separately using logistic regression models. SETTING: Ten cancer screening centres across the USA. SUBJECTS: Participants were those included in the screening arm of the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. RESULTS: Among the 44 278 individuals included in these analyses, men with diets in the most inflammatory quartile of DII scores had higher odds of all types of CRA (advanced, non-advanced and multiple (>1)) compared with those with diets in the least inflammatory quartile of DII scores. In fully adjusted models, compared with those with DII scores in quartile 1 (least inflammatory), males with DII scores in quartile 3 (adjusted odds ratio (aOR)=1·28; 95 % CI 1·12, 1·47) and quartile 4 (aOR=1·41; 95 % CI 1·23, 1·62) were more likely to have prevalent distal CRA. Higher DII scores, representing a more inflammatory diet, also were weakly associated with a higher prevalence of CRA in women. CONCLUSIONS: Implementing an anti-inflammatory diet may be an effective means of primary prevention of CRA, especially in men.