A genome-wide association study of marginal zone lymphoma shows association to the HLA region.
Journal: Nat Commun
Date: 2015 Jan 8
Major Program(s) or Research Group(s): PLCO
PubMed ID: 25569183
PMC ID: PMC4287989
Abstract: Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(-15)) and HLA-B (rs2922994, P=2.43 × 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.