Genome-wide association study of colorectal cancer identifies six new susceptibility loci.
Journal: Nat Commun
Date: 2015 Jul 7
Major Program(s) or Research Group(s): PLCO
PubMed ID: 26151821
PMC ID: PMC4967357
Abstract: Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies.